Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Whittemore, Marilyn S."'
2
Phototoxicity of 7-oxycoumarins with keratinocytes in culture
Autor: Keith Kardos, Christophe Guillon, Ned D. Heindel, Ivan Jabin, Michele M. Jetter, Thomas M. Mariano, Whittemore Marilyn S, Robert D. Rapp, Diane E. Heck, Yi Hua Jan, Jeffrey D. Laskin, Eric K. Akyea
Publikováno v: Bioorg Chem
Bioorganic chemistry, 89
Seventy-one 7-oxycoumarins, 66 synthesized and 5 commercially sourced, were tested for their ability to inhibit growth in murine PAM212 keratinocytes. Forty-nine compounds from the library demonstrated light-induced lethality. None was toxic in the a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de815f662141389c6adf1caf0dbac130
https://pubmed.ncbi.nlm.nih.gov/31170642
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5
Inhibition of interferon-γ signaling by a mercurio-substituted dihydropsoralen in murine keratinocytes
Autor: Ned D. Heindel, Christine A. Martey, Debra L. Laskin, Whittemore Marilyn S, Jeffrey D. Laskin, Diane E. Heck, Thomas M. Mariano, Anna M. Vetrano
Publikováno v: Biochemical Pharmacology. 70:1726-1734
Psoralens and ultraviolet light A (PUVA) are used in the treatment of a variety of epidermal proliferative and inflammatory disorders. These compounds are known to intercalate and photo crosslink DNA. Specific receptor proteins for psoralens have als
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ae1b2e75576346ae0d03fdcd3a7dec
https://doi.org/10.1016/j.bcp.2005.10.001
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7
Synthetic approaches to 4,8-dimethyl-5′-(N-pyridiniummethyl)- 4′,5′-dihydropsoralens and 4,8-dimethyl-5′- (N-aminomethyl)- 4′,5′-dihydropsoralens
Autor: Diane E. Heck, Jeffrey D. Laskin, Whittemore Marilyn S, Ivan Jabin, Thomas E. Mcneel, Christophe Guillon, Robert D. Rapp, Ned D. Heindel
Publikováno v: Journal of Heterocyclic Chemistry. 38:909-916
New synthetic approaches to 4,8-dimethyl-5′-(N-pyridiniummethyl)-4′,5′-dihydropsoralens and 4,8-dimemyl-5′-(N-aminomethyl)-4′,5′-dihydropsoralens are described. The 5′-halomethyl-4′,5′-dihydro-psoralen precursors are formed by elect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b905b07f877ea4af5706931dec4f4950
https://doi.org/10.1002/jhet.5570380415
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8
ChemInform Abstract: Synthetic Approaches to 4,8-Dimethyl-5′-(N-pyridiniummethyl)-4′,5′-dihydropsoralens and 4,8-Dimethyl-5′-(N-aminomethyl)-4′,5′-dihydropsoralens
Autor: Jeffrey D. Laskin, Christophe Guillon, Whittemore Marilyn S, Ned D. Heindel, Ivan Jabin, Thomas E. Mcneel, Diane E. Heck, Robert D. Rapp
Publikováno v: ChemInform. 32
New synthetic approaches to 4,8-dimethyl-5′-(N-pyridiniummethyl)-4′,5′-dihydropsoralens and 4,8-dimemyl-5′-(N-aminomethyl)-4′,5′-dihydropsoralens are described. The 5′-halomethyl-4′,5′-dihydro-psoralen precursors are formed by elect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::121ce685ce325e20185c9a63dd3eb17f
https://doi.org/10.1002/chin.200152214
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9
Mechanisms of growth inhibition in keratinocytes by mercurio-substituted 4',5'-dihydropsoralens
Autor: Whittemore Marilyn S, Jeffrey D. Laskin, Christine A. Martey, Ned D. Heindel, Debra L. Laskin, Diane E. Heck, Thomas M. Mariano, Shannon L. Gentile, Anna M. Vetrano
Publikováno v: Biochemical pharmacology. 63(11)
Psoralens, together with ultraviolet light A (PUVA), are used in the treatment of epidermal proliferative disorders. Although these compounds can enter cells and photo cross-link DNA, lipids and proteins, including a specific membrane receptor, are a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74400fa7e96f05796d9cf1363f0a43d8
https://pubmed.ncbi.nlm.nih.gov/12093477
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