Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Whitney Yin"'
Autor:
Berna Somuncu, Aysegul Ekmekcioglu, Fatma Merve Antmen, Tugce Ertuzun, Emre Deniz, Nazli Keskin, Joon Park, Ilgu Ece Yazici, Busra Simsek, Batu Erman, Whitney Yin, Burak Erman, Meltem Muftuoglu
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) pro
Externí odkaz:
https://doaj.org/article/e549a32e79fc4e04a6ae3d3fe74754da
Autor:
Rong Li, Ningyan Zhang, Zhiqiang An, Wei Xiong, Huai-Chin Chiang, Hui Deng, Junquan Liu, Victor Laurent, Samuel C Griffiths, Jasmin Dülfer, Xiujie Sun, Y Whitney Yin, Wenliang Li, Laurent P Audoly, Thomas Schürpf
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background Immune exclusion (IE) where tumors deter the infiltration of immune cells into the tumor microenvironment has emerged as a key mechanism underlying immunotherapy resistance. We recently reported a novel role of discoidin domain-containing
Externí odkaz:
https://doaj.org/article/3537ca4000574c579032deb0a579a11b
Autor:
Rachel A. Caston, Paola Fortini, Kevin Chen, Jack Bauer, Eugenia Dogliotti, Y. Whitney Yin, Bruce Demple
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12715 (2023)
After cellular differentiation, nuclear DNA is no longer replicated, and many of the associated proteins are downregulated accordingly. These include the structure-specific endonucleases Fen1 and DNA2, which are implicated in repairing mitochondrial
Externí odkaz:
https://doaj.org/article/aabe021fbe59425c8c45609903af5d6d
Autor:
Geoffrey K. Herrmann, Y. Whitney Yin
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1195 (2023)
Poly(ADP-ribose) (PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during which it catalyzes the ADP ribosylation of self and target enzymes. While
Externí odkaz:
https://doaj.org/article/d4a638b49166464dba8887b9b0f1151a
Autor:
Joon Park, Noe Baruch-Torres, Shigenori Iwai, Geoffrey K. Herrmann, Luis G. Brieba, Y. Whitney Yin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Human mitochondrial DNA contains more UV-induced lesions than the nuclear DNA due to lack of mechanism to remove bulky photoproducts. Human DNA polymerase gamma (Pol γ) is the sole DNA replicase in mitochondria, which contains a polymerase (pol) and
Externí odkaz:
https://doaj.org/article/8fc7d8cbd6e9458ebace357e1e1126d5
Publikováno v:
Molecules, Vol 28, Iss 4, p 1796 (2023)
Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation. The minimal human mtDNA replisome is com
Externí odkaz:
https://doaj.org/article/8094e99a01ed46d5b0f93c3474e838e0
Autor:
Michal R. Szymanski, Wangsheng Yu, Aleksandra M. Gmyrek, Mark A. White, Ian J. Molineux, J. Ching Lee, Y. Whitney Yin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Human EXOG is crucial for mitochondrial DNA repair. Here the authors present the crystal structures of hEXOG in apo form and as DNA complex and suggest a `tape-measure' activity to generate optimal substrates for mitochondrial base excision repair.
Externí odkaz:
https://doaj.org/article/69b2fef277bd4fcea402f22d42c7215c
Akademický článek
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Publikováno v:
Nature Structural & Molecular Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d878eaf4937cce483ffcfd17027ef41
https://doi.org/10.1038/s41594-023-00980-2
https://doi.org/10.1038/s41594-023-00980-2
Publikováno v:
Journal of the American Chemical Society. 144(51)
Most oxidative damage on mitochondrial DNA is corrected by the base excision repair (BER) pathway. However, the enzyme that catalyzes the rate-limiting reaction─deoxyribose phosphate (dRP) removal─in the multienzymatic reaction pathway has not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5811aef7809502b8f1bb6e7393976177
https://pubmed.ncbi.nlm.nih.gov/36516439
https://pubmed.ncbi.nlm.nih.gov/36516439