Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Whitney Silkworth"'
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20072 (2011)
BACKGROUND: In spite of our extensive knowledge of the more than 20 proteins associated with different amyloid diseases, we do not know how amyloid toxicity occurs or how to block its action. Recent contradictory reports suggest that the fibrils and/
Externí odkaz:
https://doaj.org/article/39960a71e3e449d8ab41d7978eaca702
Autor:
David A. Barbie, William C. Hahn, Kwok-Kin Wong, Ryan B. Corcoran, Jeffrey A. Engelman, Michael J. Eck, Suzanne Gaudet, Nir Hacohen, Shuji Ogino, William E. Gillanders, Jill P. Mesirov, Lior Rozhansky, Mary T. Labowsky, Whitney Silkworth, Edmond M. Chan, Karolina Maciag, Asher N. Page, Zhi Rong Qian, Jason T. Godfrey, Pablo Tamayo, Jacob B. Reibel, Tran C. Thai, Anna C. Schinzel, Rhine R. Shen, Susan E. Moody, Shenghong Yang, Yu Imamura, Thanh U. Barbie, Travis J. Cohoon, Amir R. Aref, Zehua Zhu
PDF file 1227K, This file contains Supplemental Figures 1-7, which provide additional supporting information for each of the main figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5893bfbe1091c688be62ffa4ec13995c
https://doi.org/10.1158/2159-8290.22529979
https://doi.org/10.1158/2159-8290.22529979
Autor:
David E. Fisher, Bradley E. Bernstein, Leonard I. Zon, Julia Newton-Bishop, Jian Jin, Yan Xiong, Brian B. Liau, C. Thomas Powell, Whitney Silkworth, Yang Feng, Yao Zhan, Lajos V. Kemeny, Ellen van Rooijen, Jennifer A. Lo, Nhu Nguyen, Yotam Drier, Joey Mark S. Diaz, Joanna Pozniak, Sathya Muralidhar, Kevin Y. Chen, Megan L. Insco, Qing Yu Weng, Shinichiro Kato
Pathways associated with G9a copy number in the Leeds melanoma cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde627f65467cad50b99ae6553a5c48a
https://doi.org/10.1158/2159-8290.22535413.v1
https://doi.org/10.1158/2159-8290.22535413.v1
Autor:
David E. Fisher, Bradley E. Bernstein, Leonard I. Zon, Julia Newton-Bishop, Jian Jin, Yan Xiong, Brian B. Liau, C. Thomas Powell, Whitney Silkworth, Yang Feng, Yao Zhan, Lajos V. Kemeny, Ellen van Rooijen, Jennifer A. Lo, Nhu Nguyen, Yotam Drier, Joey Mark S. Diaz, Joanna Pozniak, Sathya Muralidhar, Kevin Y. Chen, Megan L. Insco, Qing Yu Weng, Shinichiro Kato
Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic stimulus, such as activation of the WNT/β-catenin pathway in melanoma. This study identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36a348e4563481b651158ecb74bd36dd
https://doi.org/10.1158/2159-8290.c.6547855.v1
https://doi.org/10.1158/2159-8290.c.6547855.v1
Autor:
David A. Barbie, William C. Hahn, Kwok-Kin Wong, Ryan B. Corcoran, Jeffrey A. Engelman, Michael J. Eck, Suzanne Gaudet, Nir Hacohen, Shuji Ogino, William E. Gillanders, Jill P. Mesirov, Lior Rozhansky, Mary T. Labowsky, Whitney Silkworth, Edmond M. Chan, Karolina Maciag, Asher N. Page, Zhi Rong Qian, Jason T. Godfrey, Pablo Tamayo, Jacob B. Reibel, Tran C. Thai, Anna C. Schinzel, Rhine R. Shen, Susan E. Moody, Shenghong Yang, Yu Imamura, Thanh U. Barbie, Travis J. Cohoon, Amir R. Aref, Zehua Zhu
PDF file 146K, This file contains the legends to Supplementary Figures 1-7 and Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333c077e9ee3f485c8ade53fb1b04705
https://doi.org/10.1158/2159-8290.22529976.v1
https://doi.org/10.1158/2159-8290.22529976.v1
Autor:
David A. Barbie, William C. Hahn, Kwok-Kin Wong, Ryan B. Corcoran, Jeffrey A. Engelman, Michael J. Eck, Suzanne Gaudet, Nir Hacohen, Shuji Ogino, William E. Gillanders, Jill P. Mesirov, Lior Rozhansky, Mary T. Labowsky, Whitney Silkworth, Edmond M. Chan, Karolina Maciag, Asher N. Page, Zhi Rong Qian, Jason T. Godfrey, Pablo Tamayo, Jacob B. Reibel, Tran C. Thai, Anna C. Schinzel, Rhine R. Shen, Susan E. Moody, Shenghong Yang, Yu Imamura, Thanh U. Barbie, Travis J. Cohoon, Amir R. Aref, Zehua Zhu
S1 XLSX file 63K, This Supplementary Table contains the results of ORF screen to identify genes that can rescue the suppression of TBK1 in a KRAS-dependent cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209d5b3de765d71370d93b113a465be1
https://doi.org/10.1158/2159-8290.22529973
https://doi.org/10.1158/2159-8290.22529973
Autor:
Dieter Manstein, Martin W. LaFleur, Arlene H. Sharpe, Marcelo Pereira da Silva, Lajos Kemény, Mack Y. Su, Kristen E. Pauken, Masayoshi Kawakubo, David E. Fisher, S. Alireza Rabi, Tal Hadad Erlich, Catherine J. Wu, Rumya Raghavan, Genevieve M. Boland, Edward P. Browne, Mamunur Rashid, Yu Xu, Mai P. Hoang, Dennie T. Frederick, Jennifer A. Lo, Constance E. Brinckerhoff, Jennifer Allouche, David W. Mullins, David J. Adams, Anita A. J. van der Sande, Vikram R. Juneja, Mohsen Malehmir, Levi A. Garraway, David J. Lieb, Gordon J. Freeman, Keith T. Flaherty, Gyulnara G. Kasumova, Belinda Wang, Elisabeth Roider, Nir Hacohen, Whitney Silkworth, Qing Yu Weng
Publikováno v:
Sci Transl Med
Although immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein 1 (PD-1), can deliver durable anti-tumor effects, most patients with cancer fail to respond. Recent studies suggest that ICI efficacy correlates with a higher lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c593d3a3370645e186a5a9a975b8e9
https://doi.org/10.1126/scitranslmed.abd8636
https://doi.org/10.1126/scitranslmed.abd8636
Autor:
Joanna Pozniak, Lajos Kemény, Bradley E. Bernstein, Kevin Yining Chen, Yao Zhan, Yan Xiong, Yang Feng, Ellen van Rooijen, Yotam Drier, Megan L. Insco, Whitney Silkworth, Brian B. Liau, Julia Newton-Bishop, Joey Mark S. Diaz, Jennifer A. Lo, Sathya Muralidhar, Nhu T. Nguyen, David E. Fisher, Shinichiro Kato, Qing Yu Weng, Jian Jin, C. Thomas Powell, Leonard I. Zon
Publikováno v:
Cancer Discov
Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic stimulus, such as activation of the WNT/β-catenin pathway in melanoma. This study identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c385ab333279b0a0464c0c05c3b2e4
https://europepmc.org/articles/PMC7334057/
https://europepmc.org/articles/PMC7334057/
Autor:
Whitney Silkworth, Michel Weïwer, Stuart L. Schreiber, Andrew M. Stern, James Spoonamore, Christina Scherer, Sivaraman Dandapani, Kristina Masson, Jingqiang Wei, Nathan T. Ross, Michelle Palmer, Boris Guichard, Benito Munoz
Publikováno v:
ACS Medicinal Chemistry Letters
The KRAS oncogene is found in up to 30% of all human tumors. In 2009, RNAi experiments revealed that lowering mRNA levels of a transcript encoding the serine/threonine kinase STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fbe815e9ab716a4430c94997af6cc4
https://doi.org/10.1021/ml300246r
https://doi.org/10.1021/ml300246r
Autor:
William C. Hahn, Shenghong Yang, Susan Moody, Nir Hacohen, David A. Barbie, Ryan B. Corcoran, Mary T. Labowsky, Whitney Silkworth, Amir Reza Aref, Jason T. Godfrey, Karolina Maciag, Tran C. Thai, Lior Rozhansky, Yu Imamura, Zehua Zhu, Pablo Tamayo, Rhine R. Shen, Thanh U. Barbie, Asher N. Page, Travis J. Cohoon, Kwok-Kin Wong, Jacob B. Reibel, Jeffrey A. Engelman, Anna C. Schinzel, Zhi Rong Qian, Shuji Ogino, Jill P. Mesirov, William E. Gillanders, Suzanne Gaudet, Michael J. Eck, Edmond M. Chan
Publikováno v:
Cancer discovery. 4(4)
Although the roles of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling in KRAS-driven tumorigenesis are well established, KRAS activates additional pathways required for tumor maintenance, the inhibition of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3fb426fa773b5e29a6966a35cc9617
https://pubmed.ncbi.nlm.nih.gov/24444711
https://pubmed.ncbi.nlm.nih.gov/24444711