Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Whitney Shatz"'
Autor:
Hanine Rafidi, Sharmila Rajan, Konnie Urban, Whitney Shatz-Binder, Keliana Hui, Gregory Z. Ferl, Amrita V. Kamath, C. Andrew Boswell
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Advances in antibody engineering have enabled the construction of novel molecular formats in diverse shapes and sizes, providing new opportunities for biologic therapies and expanding the need to understand how various structural aspects affect their
Externí odkaz:
https://doaj.org/article/6c3322f467974ab2941978a377de89ce
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 600 (2023)
Over the past few decades, the complexity of molecular entities being advanced for therapeutic purposes has continued to evolve. A main propellent fueling innovation is the perpetual mandate within the pharmaceutical industry to meet the needs of nov
Externí odkaz:
https://doaj.org/article/84963d1b2f624b5dac62ff155d08d990
Autor:
Wilson Phung, Guanghui Han, Stéphanie G.I. Polderdijk, Michael Dillon, Whitney Shatz, Peter Liu, Bingchuan Wei, Pawankumar Suresh, David Fischer, Christoph Spiess, Aaron Bailey, Paul J. Carter, Jennie R. Lill, Wendy Sandoval
Publikováno v:
Data in Brief, Vol 30, Iss , Pp 105435- (2020)
The data supplied in this work are related to the research article entitled “Characterization of Bispecific and Mispaired IgGs by Native Charge-Variant Mass Spectrometry” (Phung et al., 2019). This data article describes a powerful analytical pla
Externí odkaz:
https://doaj.org/article/3d70c2e23d894d29be80278d6eb3b339
Autor:
Whitney Shatz, Philip E Hass, Nikhil Peer, Maciej T Paluch, Craig Blanchette, Guanghui Han, Wendy Sandoval, Ashley Morando, Kelly M Loyet, Vladimir Bantseev, Helen Booler, Susan Crowell, Amrita Kamath, Justin M Scheer, Robert F Kelley
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218613 (2019)
Innovative protein engineering and chemical conjugation technologies have yielded an impressive number of drug candidates in clinical development including >80 antibody drug conjugates, >60 bispecific antibodies, >35 Fc-fusion proteins and >10 immuno
Externí odkaz:
https://doaj.org/article/82a56a7b258c43e885de3b136fc2e95b
Autor:
Shraddha S, Sadekar, Mayumi, Bowen, Hao, Cai, Samira, Jamalian, Hanine, Rafidi, Whitney, Shatz-Binder, Julien, Lafrance-Vanasse, Pamela, Chan, William J, Meilandt, Amy, Oldendorp, Alavattam, Sreedhara, Ann, Daugherty, Susan, Crowell, Kristin R, Wildsmith, Jasvinder, Atwal, Reina N, Fuji, Joshua, Horvath
Publikováno v:
Clinical Pharmacology & Therapeutics. 111:826-834
Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the tissues of the central nervous system (CNS) by circumventing the blood-brain barrier and blood-CSF barrier. Developing an effective CSF drug delivery strateg
Autor:
Margaret Kenrick, Kelly M. Loyet, Peter Liu, Ashley Morando, Jeremy Good, Robert F. Kelley, Justin Scheer, Leslie J. Dickmann, Whitney Shatz, Wendy Sandoval, Teresa Davancaze, Philip E. Hass, Alyssa Morimoto
Publikováno v:
Molecular Pharmaceutics. 16:86-95
The collection of aqueous humor (phase 1 b/2 Mahalo study) from patients dosed intravitreally with anti-factor D (AFD; FCFD4514S, lampalizumab), a humanized antibody fragment previously under investigation to treat geographic atrophy (GA) secondary t
Autor:
Kelly M. Loyet, Steven T Laing, Craig Blanchette, Nardos Tassew, Whitney Shatz, Chris Schuetz, Susan Crowell
Publikováno v:
Toxicologic pathology. 49(3)
One strategy employed to prolong the ocular half-life of large molecule therapeutics is via covalent attachment to a carrier, resulting in an increase in size thereby slowing their clearance from the eye. Rabbit antigen-binding fragment conjugated to
Autor:
Yvonne Franke, Kelly M. Loyet, Ryan Abraham, Martine Darwish, Kathy Barrett, May Lin, Hong Li, Christine Tam, Craig Blanchette, Inna Zilberleyb, Janice L Wong, Kyle Mortara, Brandon Leonard, Whitney Shatz
Publikováno v:
Bioconjugate chemistry. 31(8)
Nanolipoprotein particles (NLPs), a lipid bilayer-based nanoparticle platform, have recently been developed for in vivo delivery of a variety of molecules of therapeutic interest, but their potential to deliver Fabs with valencies that exceed those o
Autor:
Christoph Spiess, Aaron O. Bailey, Paul Carter, Bingchuan Wei, Jennie R. Lill, Peter Liu, Michael Dillon, Pawan Kumar Suresh, Whitney Shatz, Wendy Sandoval, Guanghui Han, Stéphanie G.I. Polderdijk, David Fischer, Wilson Phung
Publikováno v:
Data in Brief, Vol 30, Iss, Pp 105435-(2020)
Data in Brief
Data in Brief
The data supplied in this work are related to the research article entitled "Characterization of Bispecific and Mispaired IgGs by Native Charge-Variant Mass Spectrometry" (Phung et al., 2019). This data article describes a powerful analytical platfor
Autor:
Devin Tesar, Jacob Luoma, Kelly M. Loyet, Robert F. Kelley, Leslie J. Dickmann, Catherine Shi, Li Yi, Jacob E. Corn, Philip E. Hass, Menno van Lookeren Campagne, Nisana Andersen, Michelle Z. Dion, Katie F. Maass, Emily A. Wyatt, Whitney Shatz, Karthikan Rajagopal, Justin Scheer, Kathryn Wang, Mary Mathieu
Publikováno v:
mAbs
To date, ocular antibody therapies for the treatment of retinal diseases rely on injection of the drug into the vitreous chamber of the eye. Given the burden for patients undergoing this procedure, less frequent dosing through the use of long-acting