Výsledky vyhledávání - "Whitney Jordaan"

Data from Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

Purpose:CD40 agonists hold great promise for cancer immunotherapy (CIT) as they enhance dendritic cell (DC) activation and concomitant tumor-specific T-cell priming. However, the broad expression of CD40 accounts for sink and side effects, hampering

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8328592942c80cc85bfb0e69196487
https://doi.org/10.1158/1078-0432.c.6530393.v1

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Supplementary Table 1 from Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

List of antibodies used for flow cytometry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341d1984d19a0d98f7189952320b1841
https://doi.org/10.1158/1078-0432.22480196.v1

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Supplementary material and methods from Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

Additional details on methods used for SPR assays, NanoString RNAseq and cynomolgus monkey studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0114e29374263ce4ff22105d40a384d5
https://doi.org/10.1158/1078-0432.22480187

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Supplementary Table 2 from Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

List of all genes analyzed in NanoString gene expression analysis comparing gene expression in tumors of selicrelumab and FAP-huCD40-treated mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00397bc777ec4e51ceadc36fc4554acd
https://doi.org/10.1158/1078-0432.22480193

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Supplementary Table 3 from Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

Additional data of cynomolgus monkey study showing body weight and plasma cytokine levels over the course of the study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8515b09e1298674206d0d1bd1aea6081
https://doi.org/10.1158/1078-0432.22480190.v1

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Supplementary Figures 1-6 from Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

Supplementary Figure 1 shows more details on the mode of action and design of the used antibodies. Supplementary Figure 2 displays additional APC activation data of the human and murine FAP-CD40 molecules. Supplementary Figure 3 shows additional data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6025f6d8e50b0eb6bf2f4203e2e41cc8
https://doi.org/10.1158/1078-0432.22480199

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