Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Whitney J. Sisso"'
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100291- (2021)
Summary: Drosophila larval musculature is a genetically and optically accessible system to study muscle development. Each larval muscle is a single fiber with conserved cytoarchitecture, including its sarcomere structure and composition. Here, we pre
Externí odkaz:
https://doaj.org/article/4498030a8a244b9c8841dff7711fa8c7
Autor:
Romel Somwar, Alexander Drilon, Marc Ladanyi, Eileen M. O'Reilly, Elisa de Stanchina, Ernesto Wasserman, Jeroen J. Lammerts van Bueren, Ron C.J. Schackmann, Cecile A.W. Geuijen, Marie N. O'Connor, Jim Ford, Jean Torrisi, Thrusha Chauhan, Sara H. Shameem, Morana Vojnic, Allan J.W. Lui, Marissa S. Mattar, Whitney J. Sisso, Inna Khodos, Madelyn Espinosa-Cotton, Igor Odintsov, Alison M. Schram
Supplementary Figure from Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957edba211dae8e33116bb0bbf5e53e7
https://doi.org/10.1158/2159-8290.22541186.v1
https://doi.org/10.1158/2159-8290.22541186.v1
Autor:
Romel Somwar, Alexander Drilon, Marc Ladanyi, Eileen M. O'Reilly, Elisa de Stanchina, Ernesto Wasserman, Jeroen J. Lammerts van Bueren, Ron C.J. Schackmann, Cecile A.W. Geuijen, Marie N. O'Connor, Jim Ford, Jean Torrisi, Thrusha Chauhan, Sara H. Shameem, Morana Vojnic, Allan J.W. Lui, Marissa S. Mattar, Whitney J. Sisso, Inna Khodos, Madelyn Espinosa-Cotton, Igor Odintsov, Alison M. Schram
NRG1 rearrangements are recurrent oncogenic drivers in solid tumors. NRG1 binds to HER3, leading to heterodimerization with other HER/ERBB kinases, increased downstream signaling, and tumorigenesis. Targeting ERBBs, therefore, represents a therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ad90ec0c5517efbc60698dfdb31aea
https://doi.org/10.1158/2159-8290.c.6549563.v1
https://doi.org/10.1158/2159-8290.c.6549563.v1
Autor:
Yuling Han, Jiajun Zhu, Liuliu Yang, Benjamin E. Nilsson-Payant, Romulo Hurtado, Lauretta A. Lacko, Xiaolu Sun, Aravind R. Gade, Christina A. Higgins, Whitney J. Sisso, Xue Dong, Maple Wang, Zhengming Chen, David D. Ho, Geoffrey S. Pitt, Robert E. Schwartz, Benjamin R. tenOever, Todd Evans, Shuibing Chen
Publikováno v:
Circulation Research. 130:963-977
Background: Increasing evidence suggests that cardiac arrhythmias are frequent clinical features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to bradycardia. However, it is challenging to explore human sinoatrial node (SAN) path
Autor:
Romel Somwar, Marc Ladanyi, Shawn M. Leland, Elisa de Stanchina, Marissa S. Mattar, Inna Khodos, Morana Vojnic, Exequiel M. Sisso, Renate I. Kurth, Lukas Delasos, Zebing Liu, Eric Gladstone, Whitney J. Sisso, Allan J.W. Lui, Igor Odintsov
Supplementary Figure S2 shows that cell lines without NRG1 fusions are insensitive to seribantumab and the IC50 for inhibition of growth of cells by seribantumab.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134041f90586ad7c90f01f37aad92b87
https://doi.org/10.1158/1078-0432.22480901.v1
https://doi.org/10.1158/1078-0432.22480901.v1
Autor:
Romel Somwar, Marc Ladanyi, Shawn M. Leland, Elisa de Stanchina, Marissa S. Mattar, Inna Khodos, Morana Vojnic, Exequiel M. Sisso, Renate I. Kurth, Lukas Delasos, Zebing Liu, Eric Gladstone, Whitney J. Sisso, Allan J.W. Lui, Igor Odintsov
Supplementary Materials and Methods contains additional details of experimental procedures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9584d1686b9fdd6f284ca37ca76978
https://doi.org/10.1158/1078-0432.22480886.v1
https://doi.org/10.1158/1078-0432.22480886.v1
Autor:
Romel Somwar, Marc Ladanyi, Shawn M. Leland, Elisa de Stanchina, Marissa S. Mattar, Inna Khodos, Morana Vojnic, Exequiel M. Sisso, Renate I. Kurth, Lukas Delasos, Zebing Liu, Eric Gladstone, Whitney J. Sisso, Allan J.W. Lui, Igor Odintsov
Purpose:Oncogenic fusions involving the neuregulin 1 (NRG1) gene are found in approximately 0.2% of cancers of diverse histologies. The resulting chimeric NRG1 proteins bind predominantly to HER3, leading to HER3-HER2 dimerization and activation of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a371b3bac7362a0a101ee70a5eda0064
https://doi.org/10.1158/1078-0432.c.6530549.v1
https://doi.org/10.1158/1078-0432.c.6530549.v1
Autor:
Alison M. Schram, Igor Odintsov, Madelyn Espinosa-Cotton, Inna Khodos, Whitney J. Sisso, Marissa S. Mattar, Allan J.W. Lui, Morana Vojnic, Sara H. Shameem, Thrusha Chauhan, Jean Torrisi, Jim Ford, Marie N. O'Connor, Cecile A.W. Geuijen, Ron C.J. Schackmann, Jeroen J. Lammerts van Bueren, Ernesto Wasserman, Elisa de Stanchina, Eileen M. O'Reilly, Marc Ladanyi, Alexander Drilon, Romel Somwar
Publikováno v:
Cancer Discov
NRG1 rearrangements are recurrent oncogenic drivers in solid tumors. NRG1 binds to HER3, leading to heterodimerization with other HER/ERBB kinases, increased downstream signaling, and tumorigenesis. Targeting ERBBs, therefore, represents a therapeuti
Autor:
Elisa de Stanchina, Allan J.W. Lui, Marissa Mattar, Whitney J. Sisso, Lukas Delasos, Exequiel M. Sisso, Renate I. Kurth, Zebing Liu, Marc Ladanyi, Eric Gladstone, Shawn M. Leland, Igor Odintsov, Romel Somwar, Morana Vojnic, Inna Khodos
Publikováno v:
Clinical Cancer Research. 27:3154-3166
Purpose: Oncogenic fusions involving the neuregulin 1 (NRG1) gene are found in approximately 0.2% of cancers of diverse histologies. The resulting chimeric NRG1 proteins bind predominantly to HER3, leading to HER3-HER2 dimerization and activation of
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 1, Pp 100291-(2021)
STAR Protocols, Vol 2, Iss 1, Pp 100291-(2021)
Summary Drosophila larval musculature is a genetically and optically accessible system to study muscle development. Each larval muscle is a single fiber with conserved cytoarchitecture, including its sarcomere structure and composition. Here, we pres