Výsledky vyhledávání - "Whitney F. Kellett"

Structural Basis for a Six Nucleotide Genetic Alphabet

Autor: Whitney F. Kellett, Steven A. Benner, Millie M. Georgiadis, Nigel G. J. Richards, Isha Singh, Shuichi Hoshika

Publikováno v: Journal of the American Chemical Society. 137:6947-6955

Expanded genetic systems are most likely to work with natural enzymes if the added nucleotides pair with geometries that are similar to those displayed by standard duplex DNA. Here, we present crystal structures of 16-mer duplexes showing this to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a625b15ebe6f63bb47928721956f3b70
https://doi.org/10.1021/jacs.5b03482

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Assigning the EPR Fine Structure Parameters of the Mn(II) Centers in Bacillus subtilis Oxalate Decarboxylase by Site-Directed Mutagenesis and DFT/MM Calculations

Autor: Andrew Ozarowski, Lindsey M. Easthon, Whitney F. Kellett, Alexander Angerhofer, Ursula Rothlisberger, Pablo Campomanes, Nigel G. J. Richards, Karen N. Allen

Publikováno v: Journal of the American Chemical Society

Oxalate decarboxylase (OxDC) catalyzes the Mn-dependent conversion of the oxalate monoanion into CO2 and formate. EPR-based strategies for investigating the catalytic mechanism of decarboxylation are complicated by the difficulty of assigning the sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e68d88959c993959c650e1cafdc16f5
https://doi.org/10.1021/ja408138f

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NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels

Autor: Whitney F. Kellett, Kiril L. Hristov, Rupal P. Soder, Shankar P. Parajuli, Georgi V. Petkov

Publikováno v: British Journal of Pharmacology. 168:1611-1625

Background and Purpose Overactive bladder (OAB) is often associated with abnormally increased detrusor smooth muscle (DSM) contractions. We used NS309, a selective and potent opener of the small or intermediate conductance Ca2+-activated K+ (SK or IK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::363411eebda0e9035502e0431a0d3989
https://doi.org/10.1111/bph.12049

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KV2.1 and electrically silent KV channel subunits control excitability and contractility of guinea pig detrusor smooth muscle

Autor: Qiuping Cheng, Rupal P. Soder, Kiril L. Hristov, Georgi V. Petkov, Muyan Chen, Whitney F. Kellett, Shankar P. Parajuli

Publikováno v: American Journal of Physiology-Cell Physiology. 302:C360-C372

Voltage-gated K+ (KV) channels are implicated in detrusor smooth muscle (DSM) function. However, little is known about the functional role of the heterotetrameric KV channels in DSM. In this report, we provide molecular, electrophysiological, and fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769b6ff5809836017449a44ad2650bdb
https://doi.org/10.1152/ajpcell.00303.2010

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Voltage-gated K+ channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle

Autor: Georgi V. Petkov, Muyan Chen, Whitney F. Kellett

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 299:R177-R184

Members of the voltage-gated K+ (KV) channel family are suggested to control the resting membrane potential and the repolarization phase of the action potential in urinary bladder smooth muscle (UBSM). Recent studies report that stromatoxin-1, a pept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8b60ca0a80b16e9aa93720605097bb
https://doi.org/10.1152/ajpregu.00036.2010

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Stimulation of β3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large-conductance Ca2+-activated K+ channels

Autor: Sean M. Brown, Lei Liu, Whitney F. Kellett, Georgi V. Petkov, Kiril L. Hristov, Xiangli Cui

Publikováno v: American Journal of Physiology-Cell Physiology. 295:C1344-C1353

We investigated the role of large-conductance Ca2+-activated K+ (BK) channels in β3-adrenoceptor (β3-AR)-induced relaxation in rat urinary bladder smooth muscle (UBSM). BRL 37344, a specific β3-AR agonist, inhibits spontaneous contractions of isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faa69f085325a050fa4f3551b2c6652
https://doi.org/10.1152/ajpcell.00001.2008

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