Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Whitney Dunn"'
Publikováno v:
AIDS. 27:1353-1356
We examined the relationship between plasma adipokine concentrations and ultrasound measures of vascular health in 100 HIV-infected adults on antiretroviral therapy. Leptin was positively correlated with flow-mediated dilation of the brachial artery
Autor:
Judevin Lugar, Kevin P. Quinn, Anna Liao, Darren B. Dressen, Linda Chen, Thomas N. Thompson, Elizabeth J. Holsztynska, Francine S. Farouz, Whitney Dunn, Christopher Vandevert, Ying-Zi Xu, Michael Jefferies, Thorsett Eugene D, Mark Dreyer, Michael A. Pleiss, Ted Yednock, Andrei W. Konradi, Stephen B. Freedman, Linda Mutter, Semko Christopher M
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.
Autor:
Teresa Guido, Dale Schenk, Mark Wogulis, Ferdie Soriano, Henry Grajeda, Dora Games, Kang Hu, Zhenmei Liao, Christopher Vandevert, Peter Seubert, Vasquez Nicki J, Jiping Huang, Shannan Walker, Linda Mutter, Dora Kholodenko, Michael K. Lee, Ted Yednock, Robin Barbour, George Shopp, Ivan Lieberburg, Karen Khan, Whitney Dunn, Kelly Johnson-Wood, Grace Gordon, Ruth Motter
Publikováno v:
Nature. 400(6740)
Amyloid-beta peptide (Abeta) seems to have a central role in the neuropathology of Alzheimer's disease (AD). Familial forms of the disease have been linked to mutations in the amyloid precursor protein (APP) and the presenilin genes. Disease-linked m