Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Whitney C. Duim"'
Autor:
Calvin Ly, Alexandra C. Greb, Lindsay P. Cameron, Jonathan M. Wong, Eden V. Barragan, Paige C. Wilson, Kyle F. Burbach, Sina Soltanzadeh Zarandi, Alexander Sood, Michael R. Paddy, Whitney C. Duim, Megan Y. Dennis, A. Kimberley McAllister, Kassandra M. Ori-McKenney, John A. Gray, David E. Olson
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3170-3182 (2018)
Summary: Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the
Externí odkaz:
https://doaj.org/article/fab3a30f83314b318faa3be216735c44
Autor:
David E. Olson, Whitney C. Duim, Calvin Ly, Alexandra C. Greb, Ana Cristina Grodzki, Maxemiliano V. Vargas, Pamela J. Lein
Publikováno v:
ACS Pharmacol Transl Sci
ACS pharmacology & translational science, vol 4, iss 2
ACS pharmacology & translational science, vol 4, iss 2
[Image: see text] Cortical neuron atrophy is a hallmark of depression and includes neurite retraction, dendritic spine loss, and decreased synaptic density. Psychoplastogens, small molecules capable of rapidly promoting cortical neuron growth, have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22620731ba22b40e906f626b18f9edfd
https://pubmed.ncbi.nlm.nih.gov/33860174
https://pubmed.ncbi.nlm.nih.gov/33860174
Autor:
Maxemiliano V. Vargas, David E. Olson, Whitney C. Duim, Calvin Ly, Akira J. Shimizu, Paul A. Wender
Publikováno v:
ACS chemical neuroscience, vol 11, iss 11
ACS Chem Neurosci
ACS Chem Neurosci
The marine natural product bryostatin 1 has demonstrated procognitive and antidepressant effects in animals and has been entered into human clinical trials for treating Alzheimer's disease (AD). The ability of bryostatin 1 to enhance learning and mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d2a00d7cecd2f55a502c4d9ae56573
https://escholarship.org/uc/item/2r17377c
https://escholarship.org/uc/item/2r17377c
Autor:
Paige C. Wilson, Calvin Ly, David E. Olson, Lindsay P. Cameron, Jonathan M. Wong, Kassandra M. Ori-McKenney, John A. Gray, A. Kimberley McAllister, Alexander Sood, Sina Soltanzadeh Zarandi, Whitney C. Duim, Eden V. Barragan, Michael R. Paddy, Alexandra C. Greb, Kyle F. Burbach, Megan Y. Dennis
Publikováno v:
Cell reports
Cell reports, vol 23, iss 11
Cell Reports, Vol 23, Iss 11, Pp 3170-3182 (2018)
Cell reports, vol 23, iss 11
Cell Reports, Vol 23, Iss 11, Pp 3170-3182 (2018)
SUMMARY Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713bee032880a1841b1e39356f81eef8
https://doi.org/10.1016/j.celrep.2018.05.022
https://doi.org/10.1016/j.celrep.2018.05.022
Autor:
Jie S. Zhu, Jeremy R. Tuck, Robert J. Tombari, Mark J. Kurth, Julio M. Larach, Stanley R. Bode, Phillip W. Gingrich, Whitney C. Duim, Jung-Ho Son, Makhluf J. Haddadin, Dean J. Tantillo, Hunter T. Warren, James C. Fettinger, David E. Olson
Publikováno v:
Org Lett
Organic letters, vol 21, iss 21
Organic letters, vol 21, iss 21
Photoswitches capable of accessing two geometric states are highly desirable, especially if their design is modular and incorporates a pharmacophore tethering site. We describe a redox isomerization strategy for synthesizing p-formylazobenzenes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b829e360bff7baf83ab3d7b55da7908a
https://pubmed.ncbi.nlm.nih.gov/31638403
https://pubmed.ncbi.nlm.nih.gov/31638403
Publikováno v:
ACS Chemical Biology
Polyglutamine-expanded huntingtin, the protein encoded by HTT mutations associated with Huntington's disease, forms aggregate species in vitro and in vivo. Elucidation of the mechanism of growth of fibrillar aggregates from soluble monomeric protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d01a8b7da4649b8fde7c213f243ac07
https://doi.org/10.1021/cb500335w
https://doi.org/10.1021/cb500335w
Autor:
Whitney C. Duim, Lena K. Schroeder, Martin J. Booth, Jordan R. Myers, Mary Ann Handel, Fang Huang, Christine Jacobs-Wagner, Emil B. Kromann, Derek Toomre, Felix Rivera-Molina, Thomy Phan, Edward S. Allgeyer, Mark D. Lessard, Joerg Bewersdorf, C. Patrick Lusk, James E. Rothman, George Sirinakis, Yongdeng Zhang, Irnov Irnov
Publikováno v:
ResearcherID
Cell
Cell
Summary Fluorescence nanoscopy, or super-resolution microscopy, has become an important tool in cell biological research. However, because of its usually inferior resolution in the depth direction (50–80 nm) and rapidly deteriorating resolution in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e455f5d26f4221db4d9c334863cdf428
https://www.repository.cam.ac.uk/handle/1810/291664
https://www.repository.cam.ac.uk/handle/1810/291664
Publikováno v:
The Journal of Physical Chemistry B. 116:3816-3822
When mixed with water, n-octyl β-D-glucoside forms self-assembled nanostructures, several of which are liquid crystalline and all of which depend on the water/glucoside ratio and temperature. For practical use of these phases, a detailed understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61636a92effdeb9619564405576d05d5
https://doi.org/10.1021/jp208097c
https://doi.org/10.1021/jp208097c
Publikováno v:
ChemPhysChem. 12:2387-2390
Neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases are all associated with protein misfolding, aggregation, and the accumulation of insoluble amyloid aggregates in neurons.[1] Huntington’s disease is cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc05dafb005fc97273a2f737d1c33818
https://doi.org/10.1002/cphc.201100392
https://doi.org/10.1002/cphc.201100392
Autor:
Aleksander A. Rebane, Sandy Y. Hernandez, Yu Lin, Whitney C. Duim, Stefanie E. K. Kirschbaum, Yongdeng Zhang, Mary Grace M. Velasco, Yongli Zhang, Daniel W. Moonan, Joerg Bewersdorf, Lena K. Schroeder, Alejandro Virrueta, Jane J. Long, Fang Huang, Junyi Jiao
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128135 (2015)
PLoS ONE
PLoS ONE
Single-molecule switching nanoscopy overcomes the diffraction limit of light by stochastically switching single fluorescent molecules on and off, and then localizing their positions individually. Recent advances in this technique have greatly acceler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469f842b57a1d2b59feeb7cdd7e6df86
http://europepmc.org/articles/PMC4444241?pdf=render
http://europepmc.org/articles/PMC4444241?pdf=render