Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Whitney A. Bullock"'
Autor:
Whitney A. Bullock, April M. Hoggatt, Daniel J. Horan, Andrew J. Elmendorf, Amy Y. Sato, Teresita Bellido, Gabriela G. Loots, Fredrick M. Pavalko, Alexander G. Robling
Publikováno v:
iScience, Vol 20, Iss , Pp 205-215 (2019)
Summary: Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4
Externí odkaz:
https://doaj.org/article/f7f843d78c6348eabf7967aba03f1a68
Autor:
Karl J. Lewis, Roy B-J Choi, Emily Z. Pemberton, Whitney A. Bullock, Anthony B. Firulli, Alexander G. Robling
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4427 (2019)
Wnt signaling plays a major role in bone metabolism. Advances in our understanding of secreted regulators of Wnt have yielded several therapeutic targets to stimulate osteoanabolism—the most promising of which is the Wnt inhibitor sclerostin. Scler
Externí odkaz:
https://doaj.org/article/970235e55c6e4860b5431e11fa1e30f2
Autor:
Roy B Choi, Whitney A Bullock, April M Hoggatt, Gabriela G Loots, Damian C Genetos, Alexander G Robling
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT Sclerostin antibody (romosozumab) was recently approved for clinical use in the United States to treat osteoporosis. We and others have explored Wnt‐based combination therapy to disproportionately improve the anabolic effects of sclerostin
Externí odkaz:
https://doaj.org/article/8bf70de22fa94fbbae843dd1f34ce38c
Autor:
Haisheng Yang, Whitney A Bullock, Alexandra Myhal, Philip DeShield, Daniel Duffy, Russell P Main
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT Strain magnitude has a controlling influence on bone adaptive response. However, questions remain as to how and if cancellous and cortical bone tissues respond differently to varied strain magnitudes, particularly at a molecular level. The g
Externí odkaz:
https://doaj.org/article/0c070718587246a79a7307a2997d0e68
The mTORC2 Component Rictor Is Required for Load‐Induced Bone Formation in Late‐Stage Skeletal Cells
Autor:
Karl J Lewis, Xin Yi, Christian S Wright, Emily Z Pemberton, Whitney A Bullock, William R Thompson, Alexander G Robling
Publikováno v:
JBMR Plus, Vol 4, Iss 7, Pp n/a-n/a (2020)
ABSTRACT Bone relies on mechanical cues to build and maintain tissue composition and architecture. Our understanding of bone cell mechanotransduction continues to evolve, with a few key signaling pathways emerging as vital. Wnt/β‐catenin, for exam
Externí odkaz:
https://doaj.org/article/6299d5d7b70041cf8a6f6af606efa486
Autor:
null Xiaoyu Xu, null Haisheng Yang, null Whitney A. Bullock, null Maxim A. Gallant, null Claes Ohlsson, null Teresita M. Bellido, null Russell P. Main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63f296044e011baf451e062dfc297f72
https://doi.org/10.1002/jbmr.4731/v2/response1
https://doi.org/10.1002/jbmr.4731/v2/response1
Autor:
Xiaoyu Xu, Haisheng Yang, Whitney A. Bullock, Maxim A. Gallant, Claes Ohlsson, Teresita M. Bellido, Russell P. Main
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchReferences. 38(1)
Age-related bone loss is a failure of balanced bone turnover and diminished skeletal mechanoadaptation. Estrogen receptors, ERα and ERβ, play critical roles in osteoprotective regulation activated by estrogen and mechanical signals. Previous studie
Publikováno v:
Bone. 170:116719
Autor:
Whitney A. Bullock, Xi He, Alexander G. Robling, Xinjun Zhang, Jung Min Hong, Daniel J. Horan, Emily Z. Pemberton, Roy B Choi, April M. Hoggatt
Publikováno v:
J Bone Miner Res
Wnt signaling plays a vital role in the cell biology of skeletal patterning, differentiation, and maintenance. Notum is a secreted member of the α/β-hydrolase superfamily that hydrolyzes the palmitoleoylate modification on Wnt proteins, thereby dis
Autor:
April M. Hoggatt, Whitney A. Bullock, Roy B Choi, Gabriela G. Loots, Damian C. Genetos, Alexander G. Robling
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
JBMR Plus
JBMR plus, vol 5, iss 5
JBMR Plus
JBMR plus, vol 5, iss 5
Sclerostin antibody (romosozumab) was recently approved for clinical use in the United States to treat osteoporosis. We and others have explored Wnt‐based combination therapy to disproportionately improve the anabolic effects of sclerostin inhibiti