Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Whitney A Bullock"'
Autor:
Roy B Choi, Whitney A Bullock, April M Hoggatt, Gabriela G Loots, Damian C Genetos, Alexander G Robling
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT Sclerostin antibody (romosozumab) was recently approved for clinical use in the United States to treat osteoporosis. We and others have explored Wnt‐based combination therapy to disproportionately improve the anabolic effects of sclerostin
Externí odkaz:
https://doaj.org/article/8bf70de22fa94fbbae843dd1f34ce38c
Autor:
Haisheng Yang, Whitney A Bullock, Alexandra Myhal, Philip DeShield, Daniel Duffy, Russell P Main
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT Strain magnitude has a controlling influence on bone adaptive response. However, questions remain as to how and if cancellous and cortical bone tissues respond differently to varied strain magnitudes, particularly at a molecular level. The g
Externí odkaz:
https://doaj.org/article/0c070718587246a79a7307a2997d0e68
The mTORC2 Component Rictor Is Required for Load‐Induced Bone Formation in Late‐Stage Skeletal Cells
Autor:
Karl J Lewis, Xin Yi, Christian S Wright, Emily Z Pemberton, Whitney A Bullock, William R Thompson, Alexander G Robling
Publikováno v:
JBMR Plus, Vol 4, Iss 7, Pp n/a-n/a (2020)
ABSTRACT Bone relies on mechanical cues to build and maintain tissue composition and architecture. Our understanding of bone cell mechanotransduction continues to evolve, with a few key signaling pathways emerging as vital. Wnt/β‐catenin, for exam
Externí odkaz:
https://doaj.org/article/6299d5d7b70041cf8a6f6af606efa486
Autor:
Whitney A. Bullock, April M. Hoggatt, Daniel J. Horan, Andrew J. Elmendorf, Amy Y. Sato, Teresita Bellido, Gabriela G. Loots, Fredrick M. Pavalko, Alexander G. Robling
Publikováno v:
iScience, Vol 20, Iss , Pp 205-215 (2019)
Summary: Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4
Externí odkaz:
https://doaj.org/article/f7f843d78c6348eabf7967aba03f1a68
Autor:
null Xiaoyu Xu, null Haisheng Yang, null Whitney A. Bullock, null Maxim A. Gallant, null Claes Ohlsson, null Teresita M. Bellido, null Russell P. Main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63f296044e011baf451e062dfc297f72
https://doi.org/10.1002/jbmr.4731/v2/response1
https://doi.org/10.1002/jbmr.4731/v2/response1
Autor:
Xiaoyu Xu, Haisheng Yang, Whitney A. Bullock, Maxim A. Gallant, Claes Ohlsson, Teresita M. Bellido, Russell P. Main
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchReferences. 38(1)
Age-related bone loss is a failure of balanced bone turnover and diminished skeletal mechanoadaptation. Estrogen receptors, ERα and ERβ, play critical roles in osteoprotective regulation activated by estrogen and mechanical signals. Previous studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdaf04385e998e28852ecee0edfe519c
https://pubmed.ncbi.nlm.nih.gov/36321245
https://pubmed.ncbi.nlm.nih.gov/36321245
Publikováno v:
Bone. 170:116719
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2ea4744c42dea78cd896a30d41b533
https://doi.org/10.1016/j.bone.2023.116719
https://doi.org/10.1016/j.bone.2023.116719
Autor:
Teresita Bellido, Alexander G. Robling, April M. Hoggatt, Andrew J. Elmendorf, Daniel J. Horan, Amy Y. Sato, Fredrick M. Pavalko, Gabriela G. Loots, Whitney A. Bullock
Publikováno v:
iScience
iScience, Vol 20, Iss, Pp 205-215 (2019)
iScience, Vol 20, Iss, Pp 205-215 (2019)
Summary Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757117d28677e2fd29c8eb31b422eb41
http://europepmc.org/articles/PMC6817631
http://europepmc.org/articles/PMC6817631
Autor:
Daniel J. Horan, April M. Hoggatt, Hiroki Yokota, Fredrick M. Pavalko, Alexander G. Robling, Whitney A. Bullock, Karl J. Lewis, Steven Hann, Matthew L. Warman, Gabriela G. Loots, Aimy Sebastian
Publikováno v:
J Bone Miner Res
Mechanical stimulation is a key regulator of bone mass, maintenance, and turnover. Wnt signaling is a key regulator of mechanotransduction in bone, but the role of β-catenin-an intracellular signaling node in the canonical Wnt pathway-in disuse mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9447b85ff3cffdce2ca1d0fefdd85aa4
https://doi.org/10.1002/jbmr.3812
https://doi.org/10.1002/jbmr.3812
Publikováno v:
Orthod Craniofac Res
Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell- and tissue-level properties of mechanotransduction to achieve alignment and reorganization of the dentition. However, the mechanisms of action th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d30ed24ccd60dfbf6b03a121112cef
https://doi.org/10.1111/ocr.12282
https://doi.org/10.1111/ocr.12282