First trimester placental endothelial cells from pregnancies with abnormal uterine artery Doppler are more sensitive to apoptotic stimuli

Autor: Charolidi, N, Host, AJ, Ashton, S, Tryfonos, Z, Leslie, K, Thilaganathan, B, Cartwright, JE, Whitley, GS

Failure of the placental capillary network to develop normally is associated with early onset fetal growth restriction (FGR) and pre-eclampsia (PE). Although the symptoms are observed at term, the problem begins in the first trimester. However, inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4d3d941831313e563bbbd2e623b4ec77
https://openaccess.sgul.ac.uk/id/eprint/110044/7/s41374-018-0139-z.pdf

Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL

Autor: Lumicisi, BA, Cartwright, JE, Leslie, K, Wallace, AE, Whitley, GS

Publikováno v: Human Reproduction (Oxford, England)

STUDY QUESTION: Does inhibition of dimethylarginine dimethylaminohydrolase (DDAH) increase the sensitivity of trophoblasts to TRAIL-induced apoptosis? SUMMARY ANSWER: Inhibition of DDAH1, but not DDAH2, increases the sensitivity of trophoblasts to TR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7417a54757c7f350763a936509913747
http://europepmc.org/articles/PMC4507332

Trophoblast Dependent Secretion of Stannocalcin-1 and Interleukin-8 by Endothelial Cells and Their Role as Possible Mediators of Spiral Artery Remodeling

Autor: Esmail, A, Bishop, A, Cartwright, JE, Whitley, GS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::61871b13ecbd9f817c5e76f6913b51f5

Investigating the role of tumour cell derived iNOS on tumour growth and vasculature in vivo using a tetracycline regulated expression system

Autor: Papaevangelou, E, Whitley, GS, Johnstone, AP, Robinson, SP, Howe, FA

Nitric oxide (NO) is a free radical signalling molecule involved in various physiological and pathological processes, including cancer. Both tumouricidal and tumour promoting effects have been attributed to NO, making its role in cancer biology contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::99415ffbc4806d3d50c812ed0cc33929

Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function

Autor: Wallace, AE, Fraser, R, Gurung, S, Goulwara, SS, Whitley, GS, Johnstone, AP, Cartwright, JE

Publikováno v: Wallace, A E, Fraser, R, Gurung, S, Goulwara, S S, Whitley, G S, Johnstone, A P & Cartwright, J E 2014, ' Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function ', Human Reproduction, vol. 29, no. 4, pp. 652-60 . https://doi.org/10.1093/humrep/deu017
Human Reproduction

STUDY QUESTION: Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?SUMMARY ANSWER: Expression leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1438438a113f3433288d8309faee8c47
https://www.pure.ed.ac.uk/ws/files/343358312/deu017.pdf