A study of the biogenesis of secreted proteins in Saccharomyces cerevisiae

Autor: Whitley, Paul

The maturation of many secreted proteins in Saccharomyces cerevisiae involves the cleavage of a precursor polypeptide after pairs of basic residues by a specific protease (Kex2p) at a late stage in the secretory pathway. The aim of this project was t

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.663727

Arabidopsis FAB1/PIKfyve Proteins Are Essential for Development of Viable Pollen

Autor: Whitley, Paul, Hinz, Steven, Doughty, James

Publikováno v: Plant Physiology, 2009 Dec 01. 151(4), 1812-1822.

Externí odkaz: https://www.jstor.org/stable/40537620

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Transmembrane but not soluble helices fold inside the ribosome tunnel

Autor: Bañó-Polo, Manuel, Baeza-Delgado, Carlos, Tamborero, Silvia, Hazel, Anthony, Grau, Brayan, Nilsson, IngMarie, Whitley, Paul, Gumbart, James C., von Heijne, Gunnar, Mingarro, Ismael

Publikováno v: Bañó Polo, Manuel Baeza Delgado, Carlos Tamborero Capilla, Silvia Hazel, Anthony Grau, Brayan Nilsson, IngMarie Whitley, Paul Gumbart, James C. Heijne, Gunnar von Mingarro Muñoz, Ismael 2018 Transmembrane but not soluble helices fold inside the ribosome tunnel Nature Communications 9 5246 1 9
RODERIC. Repositorio Institucional de la Universitat de Valéncia
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Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications

Integral membrane proteins are assembled into the ER membrane via a continuous ribosome-translocon channel. The hydrophobicity and thickness of the core of the membrane bilayer leads to the expectation that transmembrane (TM) segments minimize the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cef89ea07df1f6d0b2a85d7952948989
https://doi.org/10.1038/s41467-018-07554-7

Different conformations of nascent polypeptides during translocation across the ER membrane

Autor: Whitley Paul, Nilsson IngMarie, Mingarro Ismael, von Heijne Gunnar

Publikováno v: BMC Cell Biology, Vol 1, Iss 1, p 3 (2000)

Abstract Background In eukaryotic cells, proteins are translocated across the ER membrane through a continuous ribosome-translocon channel. It is unclear to what extent proteins can fold already within the ribosome-translocon channel, and previous st

Externí odkaz: https://doaj.org/article/44fbdaf8f4c94be7868d630e9985c370