Zobrazeno 1 - 10
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pro vyhledávání: '"White, Ian R"'
Autor:
Wijesuriya, Rushani, Moreno-Betancur, Margarita, Carlin, John B, White, Ian R, Quartagno, Matteo, Lee, Katherine J
Longitudinal studies are frequently used in medical research and involve collecting repeated measures on individuals over time. Observations from the same individual are invariably correlated and thus an analytic approach that accounts for this clust
Externí odkaz:
http://arxiv.org/abs/2404.06967
A common concern in non-inferiority (NI) trials is that non adherence due, for example, to poor study conduct can make treatment arms artificially similar. Because intention to treat analyses can be anti-conservative in this situation, per protocol a
Externí odkaz:
http://arxiv.org/abs/2312.00494
The estimands framework outlined in ICH E9 (R1) describes the components needed to precisely define the effects to be estimated in clinical trials, which includes how post-baseline "intercurrent" events (IEs) are to be handled. In late-stage clinical
Externí odkaz:
http://arxiv.org/abs/2308.10857
Autor:
Godolphin, Peter J, Marlin, Nadine, Cornett, Chantelle, Fisher, David J, Tierney, Jayne F, White, Ian R, Rogozińska, Ewelina
Individual participant data (IPD) meta-analyses of randomised trials are considered a reliable way to assess participant-level treatment effect modifiers but may not make the best use of the available data. Traditionally, effect modifiers are explore
Externí odkaz:
http://arxiv.org/abs/2302.12801
Although the biostatistical scientific literature publishes new methods at a very high rate, many of these developments are not trustworthy enough to be adopted by the scientific community. We propose a framework to think about how a piece of methodo
Externí odkaz:
http://arxiv.org/abs/2209.13358
Publikováno v:
Journal of Medical Internet Research, Vol 17, Iss 7, p e170 (2015)
BackgroundPrevious research on the effectiveness of online alcohol interventions for college students has shown mixed results. Small benefits have been found in some studies and because online interventions are inexpensive and possible to implement o
Externí odkaz:
https://doaj.org/article/d93f60dff08145639ed79f5e4edf6588
Using modified intention-to-treat as a principal stratum estimator for failure to initiate treatment
Publikováno v:
Clin Trials. 2023 Jun;20(3):269-275
Background: A common intercurrent event affecting many trials is when some participants do not begin their assigned treatment. Many trials use a modified intention-to-treat (mITT) approach, whereby participants who do not initiate treatment are exclu
Externí odkaz:
http://arxiv.org/abs/2206.10453
Autor:
Mainzer, Rheanna M., Nguyen, Cattram D., Carlin, John B., Moreno-Betancur, Margarita, White, Ian R., Lee, Katherine J.
Multiple imputation (MI) is a popular method for handling missing data. Auxiliary variables can be added to the imputation model(s) to improve MI estimates. However, the choice of which auxiliary variables to include in the imputation model is not al
Externí odkaz:
http://arxiv.org/abs/2203.16717
Autor:
Clements, Michelle N., White, Ian R., Copas, Andrew J., Cornelius, Victoria, Cro, Suzie, Dunn, David T, Quartagno, Matteo, Turner, Rebecca M., Tweed, Conor D., Walker, A. Sarah
Effective decision making from randomised controlled clinical trials relies on robust interpretation of the numerical results. However, the language we use to describe clinical trials can cause confusion both in trial design and in comparing results
Externí odkaz:
http://arxiv.org/abs/2203.11164
Autor:
Sharpe, Michael, Walker, Jane, van Niekerk, Maike, Toynbee, Mark, Magill, Nicholas, Frost, Chris, White, Ian R, Walker, Simon, Duarte, Ana, Owens, Colm, Dickens, Chris, Price, Annabel, Aitken, Peter, Bajorek, Tomasz, Berk, Gunes, Bold, Rhian, Burke, Katy, Burns, Jonathan, Campbell, Shelley, Chaitow, Hannah, Clay, Felix, Daly, Michael, Emmens, Tobit, Hampsey, Elliot, Hannaway, Naomi, Harris, Jessica, Harwood, Rowan, Hill, Laura, Hobbs, Harriet, Hollands, Laura, Howitt, Sophie, Kant, Rhian, Lamb, Sarah E, Lasserson, Daniel, Lee, Hochang Benjamin, Macey, Eleanor, Palmer, Aelfrida, Philps, Julie, Pollard, Louise, Rocroi, Isabelle, Scholz, Anna, Shepperd, Sasha, Sirois-Giguere, Gabrielle, Solomons, Luke, Steward, Ben, Turner, Will, Yousif, Michael
Publikováno v:
In The Lancet Psychiatry September 2024 11(9):684-695