Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice

Autor: White, Christopher I., Jansen, Maurits A., McGregor, Kieran, Mylonas, Katie J., Richardson, Rachel V., Thomson, Adrian, Moran, Carmel M., Seckl, Jonathan R., Walker, Brian R., Chapman, Karen E., Gray, Gillian A.

Publikováno v: Endocrinology

Global deficiency of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme that regenerates glucocorticoids within cells, promotes angiogenesis, and reduces acute infarct expansion after myocardial infarction (MI), suggesting that 11β-HSD1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19a6dc0ce49e39146d7e5cf6d4a23f8a
http://europepmc.org/articles/PMC4701896

Cardiomyocyte and vascular smooth muscle independent 11β-hydroxysteroid dehydrogenase 1 amplifies infarct expansion, hypertrophy and the development of heart failure following myocardial infarction in male mice

Autor: White, Christopher I, Jansen, Maurits A, McGregor, Kieran, Mylonas, Katie J, Richardson, Rachel V, Thomson, Adrian, Moran, Carmel M, Seckl, Jonathan R, Walker, Brian R, Chapman, Karen E, Gray, Gillian A

Publikováno v: White, C I, Jansen, M A, McGregor, K, Mylonas, K J, Richardson, R V, Thomson, A, Moran, C M, Seckl, J R, Walker, B R, Chapman, K E & Gray, G A 2016, ' Cardiomyocyte and vascular smooth muscle independent 11β-hydroxysteroid dehydrogenase 1 amplifies infarct expansion, hypertrophy and the development of heart failure following myocardial infarction in male mice ', Endocrinology, vol. 157, no. 1, pp. 346–357 . https://doi.org/10.1210/en.2015-1630

Global deficiency of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), an enzyme that regenerates glucocorticoids within cells, promotes angiogenesis and reduces acute infarct expansion following myocardial infarction (MI) suggesting that 11β-HSD1 ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::6d9a427fccad1017f269228fa72ac95e
https://www.pure.ed.ac.uk/ws/files/22064966/G_Gray_Cardiomyocyte.pdf

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11ß-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI.

Autor: Mylonas, Katie J., Turner, Neil A., Bageghni, Sumia A., Kenyon, Christopher J., White, Christopher I., McGregor, Kieran, Kimmitt, Robert A., Sulston, Richard, Kelly, Valerie, Walker, Brian R., Porter, Karen E., Chapman, Karen E., Gray, Gillian A.

Publikováno v: Journal of Endocrinology; Jun2017, Vol. 233 Issue 3, p315-327, 13p

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