Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA.

Autor: Price AM; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Steinbock RT; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Cell & Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA., Di C; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hayer KE; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Li Y; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Herrmann C; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Cell & Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA., Parenti NA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Whelan JN; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Weiss SR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Weitzman MD; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Feb 22; Vol. 50 (3), pp. 1201-1220.

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes.

Autor: Li Y; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104; weisssr@pennmedicine.upenn.edu yizelee@gmail.com.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Renner DM; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Comar CE; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Whelan JN; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Reyes HM; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Cardenas-Diaz FL; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Truitt R; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Tan LH; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Dong B; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195., Alysandratos KD; Department of Medicine, The Pulmonary Center, Center for Regenerative Medicine, Boston University School of Medicine, Boston, MA 02118., Huang J; Department of Medicine, The Pulmonary Center, Center for Regenerative Medicine, Boston University School of Medicine, Boston, MA 02118., Palmer JN; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Adappa ND; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Kohanski MA; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Kotton DN; Department of Medicine, The Pulmonary Center, Center for Regenerative Medicine, Boston University School of Medicine, Boston, MA 02118., Silverman RH; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195., Yang W; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Morrisey EE; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104., Cohen NA; Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.; Division of Otolaryngology, Department of Surgery, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA 19104.; Monell Chemical Senses Center, Philadelphia, PA 19104., Weiss SR; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104; weisssr@pennmedicine.upenn.edu yizelee@gmail.com.; Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Apr 20; Vol. 118 (16).

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes.

Autor: Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey E, Cohen NA, Weiss SR

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Nov 02. Date of Electronic Publication: 2020 Nov 02.

Identification of Respiratory Syncytial Virus Nonstructural Protein 2 Residues Essential for Exploitation of the Host Ubiquitin System and Inhibition of Innate Immune Responses.

Autor: Whelan JN; Division of Allergy and Immunology, Department of Internal Medicine, and the Joy McCann Culverhouse Airway Diseases Research Center, University of South Florida Morsani College of Medicine, Tampa, Florida, USA., Tran KC; Division of Allergy and Immunology, Department of Internal Medicine, and the Joy McCann Culverhouse Airway Diseases Research Center, University of South Florida Morsani College of Medicine, Tampa, Florida, USA., van Rossum DB; Department of Biology, and the Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA., Teng MN; Division of Allergy and Immunology, Department of Internal Medicine, and the Joy McCann Culverhouse Airway Diseases Research Center, University of South Florida Morsani College of Medicine, Tampa, Florida, USA mteng@health.usf.edu.

Publikováno v: Journal of virology [J Virol] 2016 Jun 24; Vol. 90 (14), pp. 6453-6463. Date of Electronic Publication: 2016 Jun 24 (Print Publication: 2016).