Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Whei-Mei Wu"'
Publikováno v:
Journal of pharmaceutical sciences. 105(9)
Atopic dermatitis of sensitive areas such as the face, particularly in children, is a difficult disease to treat as the standard therapeutic, topical steroids, is contraindicated for this application in children. Hydrocortisone (HC) can be used in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849811b1ef59d4feb71edbdc0c35598d
https://pubmed.ncbi.nlm.nih.gov/27179671
https://pubmed.ncbi.nlm.nih.gov/27179671
Publikováno v:
Pharmaceutical Research. 20:1681-1689
Purpose. To design and evaluate a new class of soft anticholinergics with subtype selectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::021c4507203c6fcc3a38cc076909b4c5
https://doi.org/10.1023/a:1026160023030
https://doi.org/10.1023/a:1026160023030
Publikováno v:
Journal of Drug Targeting. 10:63-71
Brain-targeted delivery of various drugs can be successfully achieved by chemical delivery systems (CDS) that contain a 1,4-dihydropyridine-based redox targetor moiety and undergo a sequential metabolism. However, the susceptibility of this moiety to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d9129c6d87e5906d308c10075cd9f6
https://doi.org/10.1080/10611860290007540
https://doi.org/10.1080/10611860290007540
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:1059-1063
A chemical targeting system for [Leu 2 , Pip 3 ]-TRH (Gln,Leu,Pip) was synthesized in order to allow its specific delivery to the central nervous system (CNS). Sequential metabolism of the obtained ‘packaged’ chemical delivery system, (CDS), DHT-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3fcbd8ad14c1f8fea71e12d7fdb39c2
https://doi.org/10.1016/s0968-0896(00)00043-2
https://doi.org/10.1016/s0968-0896(00)00043-2
Publikováno v:
Journal of Medicinal Chemistry. 41:3773-3781
The design, synthesis, and pharmacological evaluation of brain-targeted chemical delivery systems (CDS) for a kyotorphin analogue (Tyr-Lys) are described. The brain-targeted compound contains the active peptide in a packaged, disguised form, flanked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925bed352d639aac7c5e77697d1ed66b
https://doi.org/10.1021/jm970715l
https://doi.org/10.1021/jm970715l
Publikováno v:
Drug Development Research. 43:117-127
The design and evaluation of two new soft anticholinergic agents, ethoxycarbonylphenylcyclopentylacetyl-N,N-dimethyltropinium methyl sulfate (PCMS-1) and methoxycarbonylphenylcyclopentylacetyl-N,N-dimethyltropinium methyl sulfate (PCMS-2) are present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a02ea7d21531b3510d8e9e5f3c42714
https://doi.org/10.1002/(sici)1098-2299(199802)43:2<117::aid-ddr5>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199802)43:2<117::aid-ddr5>3.0.co
Autor:
Gábor Somogyi, Laszlo Prokai, Nicholas Bodor, M. Dulce C. Barros, Hassan H. Farag, Whei-Mei Wu
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 13:389-403
S-(-)- Timolol maleate was oxidized, using the modified Pfitzner-Mofatt method, to the corresponding keto analog, which was then coupled with either hydroxylamine or methoxyamine in the same reaction medium. The products separated, timolone oxime (TO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb1f2d4a4fb216786ccff61b4ba2a32
https://doi.org/10.1089/jop.1997.13.389
https://doi.org/10.1089/jop.1997.13.389
Publikováno v:
Journal of Pharmaceutical Sciences. 85:496-504
We espouse the application of a novel chemical delivery system (CDS) approach to a delivery mechanism for drug targeting to lung tissue using the 1,2-dithiolane-3-pentyl moiety of lipoic acid as the “targetor moiety”. The synthesis and the physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffba5f6f96b4d4e7e60e3b7e3cab64a7
https://doi.org/10.1021/js9504200
https://doi.org/10.1021/js9504200
Publikováno v:
Pharmaceutical Research. 12:329-336
A new type of ultra-short acting β-blocker which might prove advantageous in treating acute arrhythmias was designed, synthesized and investigated. Based on the soft drug “inactive metabolite approach,” the inactive phenylacetic acid metabolite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea888643f946543dc3160f85b8df09cc
https://doi.org/10.1023/a:1016283930696
https://doi.org/10.1023/a:1016283930696
Publikováno v:
Pharmaceutical Research. 12:869-874
Purpose. As a safe anti-inflammatory corticosteroid, the utility of loteprednol etabonate (LE) for the treatment of gastrointestinal inflammation, via oral and rectal administration, was investigated in rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba8aa6e5398449ef3c120d1adde77371
https://doi.org/10.1023/a:1016213121069
https://doi.org/10.1023/a:1016213121069