Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Wheeseong Lee"'
Publikováno v:
Trends in Endocrinology & Metabolism. 33:722-735
Metabolites generated from cellular and tissue metabolism have been rediscovered in recent years as signalling molecules. They may act as cofactor of enzymes or be linked to proteins as post-translational modifiers. They also act as ligands for speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a23f22fba26484d85316980da1751f
https://doi.org/10.1016/j.tem.2022.07.004
https://doi.org/10.1016/j.tem.2022.07.004
Publikováno v:
Inflammatory Bowel Diseases. 29:S4-S5
Macrophages are the first line of defense against self-stimuli and non-self-pathogens and adopt diverse activation states by reprogramming their cell metabolism and thereby polarizing their phenotypes in order to drive their pro-inflammatory or pro-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7912e1fcf5787a108be6bbb6a9e1817c
https://doi.org/10.1093/ibd/izac247.011
https://doi.org/10.1093/ibd/izac247.011
Autor:
Wheeseong Lee, Scott E. Denmark
Publikováno v:
Chemistry - An Asian Journal. 3:327-341
A model compound was de- signed to study the relative orientation of enol silane and carbonyl moieties in the Mukaiyama aldol reaction.The cyclization must proceed with either a synclinal or an antiperiplanar orienta- tion of the aldehyde with respec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e2caefcfbf4f2645826137375cfa55
https://doi.org/10.1002/asia.200700300
https://doi.org/10.1002/asia.200700300
Autor:
Richard I. Feldman, Gary Phillips, Marc Adler, Daguang Zhu, Elena Ho, Wheeseong Lee, Mark A. Polokoff, Hongyi Yu, Dao Lentz, Marc Whitlow, Arnaiz Damian O, Kochanny Monica, Babu Subramanyam, Imadul Islam, James M. Wu, Judi Bryant, Yuo-Ling Chou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3814-3818
HTS screening identified 1 with micromolar inhibitory activity against PDK1. Optimization of 1 afforded 4i (BX-517) which has single-digit nanomolar activity against PDK1 and excellent selectivity against PKA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9b5b6c85e996a38c96e34d7d0210bc
https://doi.org/10.1016/j.bmcl.2007.04.071
https://doi.org/10.1016/j.bmcl.2007.04.071
Autor:
Dao Lentz, Marc Whitlow, Kenneth J. Shaw, Karna Lyn Sacchi, Sakata Steven T, Janette Walters, Kathy White, Joseph Post, Bin Ye, Wheeseong Lee, Kochanny Monica, Elena Ho, Amy Liang, Ron Vergona, Janice Ewing, Morrissey Michael M, Karanjawala Rushad E, Gary Phillips, Zuchun Zhao, Brian D. Griedel, Babu Subramanyam, Marc Adler
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2127-2146
A series of thiophene-containing non-amidine factor Xa inhibitors is described. Simple methyl-substituted thiophene analogs were relatively weak inhibitors. However, introduction of hydrophilic substituents at C-4 or C-5 of the thiophene afforded inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b4b05420f1f0b4641803f66b53494f
https://doi.org/10.1016/j.bmc.2006.12.019
https://doi.org/10.1016/j.bmc.2006.12.019
Autor:
Dave Davey, Arnaiz Damian O, Shou-Fu Lu, Laura Dunning, Yuo-Ling Chou, James Onuffer, Robert G. Wei, Gary Phillips, Wheeseong Lee, Bin Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:231-234
High throughput screening (HTS) led to the identification of the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde as a CCR5 receptor antagonist. Initial modifications of the guanylhydrazone series indicated that substitution of the benzyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4925686f9f66976b3a1592c816c6e8c0
https://doi.org/10.1016/j.bmcl.2006.09.052
https://doi.org/10.1016/j.bmcl.2006.09.052
Autor:
Kenneth J. Shaw, Bauer Shawn M, Amy Liang, Brad O. Buckman, Wheeseong Lee, Brian D. Griedel, Ghannam Ameen F, Qingyu Wu, Zuchun Zhao, Khim Seock-Kyu, Karna Lyn Sacchi, Bin Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3361-3365
Compound 2 was identified by high throughput screening as a novel PAI-1 inhibitor. Systematic optimization of the A, B, and C segments of 2 resulted in the identification of a more potent compound 39 with good oral bioavailability. The synthesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701deb338599f8ed8ca158f60220935d
https://doi.org/10.1016/s0960-894x(03)00686-3
https://doi.org/10.1016/s0960-894x(03)00686-3
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b66497de15d46431ce9af176a8a95c5
https://doi.org/10.1002/chin.199533029
https://doi.org/10.1002/chin.199533029
Autor:
Scott E. Denmark, Wheeseong Lee
Publikováno v:
Tetrahedron Letters. 33:7729-7732
In aqueous medium, base-induced aldol condensations of keto aldehyde 1 show high anti-selectivity independent of metal ion and water content of the solvent. The acid-induced aldol condensations affords syn-aldol products in variable selectivity depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::545f3e421f1c7fdfbe964fbacd303784
https://doi.org/10.1016/0040-4039(93)88030-m
https://doi.org/10.1016/0040-4039(93)88030-m
Autor:
Yuo-Ling Chou, John Morser, Marc Adler, Wheeseong Lee, Joseph Post, David R. Light, Kochanny Monica, Karna Lyn Sacchi, Dao Lentz, Arnaiz Damian O, Marc Whitlow, Bin Ye, Amy Liang, Ron Vergona, Richard W. Fitch, Mark E. Sullivan, Sarah Cheeseman, Janice Ewing, Zuchun Zhao, Babu Subramanyam, Kathy White, Kenneth J. Shaw, Karanjawala Rushad E, Janette Walters, Brian D. Griedel, Yi-Xin Wang, William P. Dole, Michael M. Morrissey, Steven T. Sakata, Galina Rumennik, Shung C. Wu
Publikováno v:
Journal of medicinal chemistry. 50(13)
There remains a high unmet medical need for a safe oral therapy for thrombotic disorders. The serine protease factor Xa (fXa), with its central role in the coagulation cascade, is among the more promising targets for anticoagulant therapy and has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9b314570fda62e22e2ae9d385e5ac9
https://pubmed.ncbi.nlm.nih.gov/17536795
https://pubmed.ncbi.nlm.nih.gov/17536795