Toxicity-dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials

Autor: Wheeler, GM, Sweeting, MJ, Mander, AP

Phase I trials of anti-cancer therapies aim to identify a maximum tolerated dose (MTD), defined as the dose that causes unacceptable toxicity in a target proportion of patients. Both rule-based and model-based methods have been proposed for MTD recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bb27196ada431922141a72085ea513bd
http://hdl.handle.net/10044/1/86403

Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial

Autor: Ahern, AL, Wheeler, GM, Aveyard, P, Boyland, EJ, Halford, JCG, Mander, AP, Woolston, J, Thomson, AM, Tsiountsioura, M, Cole2, Mead, BR, Irvine, L, Turner, D, Suhrcke, M, Pimpin, L, Retat, L, Jaccard, A, Webber, L, Cohn, S, Jebb, SA

$\textit{Background}$ Evidence exist that primary care referral to an open-group behavioural programme is an effective strategy for management of obesity, but little evidence on optimal intervention duration is available. We aimed to establish whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc28884051563bcfb15133a6b007e16d

Appendage regeneration requires IMPDH2 and creates a sensitized environment for enzyme filament formation.

Autor: McCartney ME; Department of Biochemistry. University of Washington, Seattle WA., Wheeler GM; Department of Biochemistry. University of Washington, Seattle WA., O'Neill AG; Department of Biochemistry. University of Washington, Seattle WA.; Program in Biological Physics, Structure, and Design. University of Washington, Seattle WA., Patel JH; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia PA., Litt ZR; Department of Biochemistry. University of Washington, Seattle WA., Calise SJ; Department of Biochemistry. University of Washington, Seattle WA., Kollman JM; Department of Biochemistry. University of Washington, Seattle WA., Wills AE; Department of Biochemistry. University of Washington, Seattle WA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 21. Date of Electronic Publication: 2024 Aug 21.

Effectiveness and cost-effectiveness of referral to a commercial open group behavioural weight management programme in adults with overweight and obesity: 5-year follow-up of the WRAP randomised controlled trial.

Autor: Ahern AL; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK. Electronic address: ala34@cam.ac.uk., Breeze P; School of Health and Related Research, University of Sheffield, Sheffield, UK., Fusco F; Primary Care Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Sharp SJ; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Islam N; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Wheeler GM; Imperial Clinical Trials Unit, Imperial College London, UK., Hill AJ; School of Medicine, University of Leeds, Leeds, UK., Hughes CA; Norwich Medical School, University of East Anglia, Norwich, UK., Duschinsky R; Primary Care Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Thomas C; School of Health and Related Research, University of Sheffield, Sheffield, UK., Bates S; School of Health and Related Research, University of Sheffield, Sheffield, UK., Woolston J; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Stubbings M; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Whittle F; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Boothby C; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Bostock J; Patient and Public Involvement Representative, Quality Safety Outcomes Policy Research Unit, University of Kent, Canterbury, UK., Jebb S; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals, Oxford, UK., Aveyard P; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals, Oxford, UK., Boyland E; Department of Psychology, University of Liverpool, Liverpool, UK., Halford JCG; School of Psychology, University of Leeds, Leeds, UK; Department of Psychology, University of Liverpool, Liverpool, UK., Morris S; Primary Care Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Brennan A; School of Health and Related Research, University of Sheffield, Sheffield, UK., Griffin SJ; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Primary Care Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Publikováno v: The Lancet. Public health [Lancet Public Health] 2022 Oct; Vol. 7 (10), pp. e866-e875.

Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs.

Autor: Burnett T; Department of Mathematics and Statistics, Lancaster University, Fylde College, Lancaster, LA1 4YF, UK. t.burnett1@lancaster.ac.uk., Mozgunov P; Department of Mathematics and Statistics, Lancaster University, Fylde College, Lancaster, LA1 4YF, UK., Pallmann P; Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University, Cardiff, UK., Villar SS; MRC Biostatistics Unit, University of Cambridge School of Clinical Medicine, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK., Wheeler GM; Cancer Research UK & UCL Cancer Trials Centre, University College London, 90 Tottenham Court Road, London, W1T 4TJ, UK., Jaki T; Department of Mathematics and Statistics, Lancaster University, Fylde College, Lancaster, LA1 4YF, UK.; MRC Biostatistics Unit, University of Cambridge School of Clinical Medicine, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK.

Publikováno v: BMC medicine [BMC Med] 2020 Nov 19; Vol. 18 (1), pp. 352. Date of Electronic Publication: 2020 Nov 19.