Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Wheatcroft, SB"'
Autor:
Maqbool, A, Watt, N, Haywood, N, Viswambharan, H, Skromna, A, Makava, N, Visnagri, A, Shawer, HM, Bridge, K, Muminov, SK, Griffin, K, Beech, DJ, Wheatcroft, SB, Porter, KE, Simmons, KJ, Sukumar, P, Shah, AM, Cubbon, RM, Kearney, MT, Yuldasheva, NY
Insulin resistance leads to excessive endothelial cell (EC) superoxide generation and accelerated atherosclerosis. The principal source of superoxide from the insulin-resistant endothelium is the Nox2 isoform of NADPH oxidase. Here we examine the the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::46075043e9cc4f8e95f89247d9a8e50b
Autor:
Rashid, ST, Haywood, NJ, Yuldasheva, NY, Smith, J, Aziz, A, Scott, DJA, Kearney, MT, Wheatcroft, SB
Publikováno v:
Obesity Science & Practice
Summary Introduction Preservation of structural integrity of the endothelial monolayer and maintenance of endothelial cell function are of critical importance in preventing arterial thrombosis, restenosis and atherosclerosis. Obesity has been intimat
Autor:
Sengupta, A, Patel, PA, Yuldasheva, NY, Mughal, RS, Galloway, S, Viswambharan, H, Walker, AMN, Aziz, A, Smith, J, Ali, N, Mercer, BN, Imrie, H, Sukumar, P, Wheatcroft, SB, Kearney, MT, Cubbon, RM
Publikováno v:
Endocrinology
Reduced systemic insulin signaling promotes endothelial dysfunction and diminished endogenous vascular repair. We investigated whether restoration of endothelial insulin receptor expression could rescue this phenotype. Insulin receptor knockout (IRKO
Autor:
Fearnley, GW, Abdul-Zani, I, Latham, AM, Hollstein, MC, Ladbury, JE, Wheatcroft, SB, Odell, AF, Ponnambalam, S
Publikováno v:
Biology Open, Vol 8, Iss 5 (2019)
New blood vessel sprouting (angiogenesis) and vascular physiology are fundamental features of metazoan species but we do not fully understand how signal transduction pathways regulate diverse vascular responses. The vascular endothelial growth factor
Autor:
Howell, SJ, Hoeks, SE, West, RM, Wheatcroft, SB, Hoeft, A, OBTAIN Investigators of European Society of Anaesthesiology (ESA, Leva, B, Plichon, B, Damster, S, Momeni, M, Watremez, C, Kahn, D, Dincq, A-S, Danila, A, Wittmann, M, Struck, R, Rüddel, T, Kessler, F, Rasche, S, Matsota, P, Hasani, A, Gudaityte, J, Karbonskiene, A, Ferreira, R, Carvalho, S, Tomescu, D, Martac, C, Grintescu, I, Mirea, L, Serrano, L, Sierra, P, Sabaté, S, Hernando, D, Matute, P, Trashorras, M, Suñé, M, Sarmiento, L, Hervias, A, González, O, Hermina, A, Navarro Perez, R, Orts, M, Fernandez-Garcia, R, Sanchez Pérez, D, Sepulveda Gil, I, Monedero, P, Hidalgo, F, Mbongo, C, Pont, AR, Reyes, HM, Bartolo, CG, Galera, SL, Valentijn, T, Stolker, RJ, Tugrul, M, Demirel, EE, Hough, M, Griffiths, K, Birch, S, Beardow, Z, Elliot, S, Thompson, J, Bowrey, S, Northey, M, Melson, H, Telford, R, Nadolski, M, Potter, A, Fuller, D, Rose, A, Varma, S, Simeson, K, Pettit, J, Smith, N, Martinson, V, Sleight, L, Naylor, C, Watt, P, Raymode, P, Dunk, N, Twohey, L, Hollos, L, Davies, S, Gibson, A, Coleman, Z, Tamm, T, Joscak, J, Zsisku, L, Zuleika, M, Carvalho, P, Collyer, T, Ryan, J, Colling, K, Dharmarajah, S, Krishnan, A, Paddle, J, Fouracres, A, Arnell, K, Muhammad, K
Background: The perioperative management of antiplatelet therapy in noncardiac surgery patients who have undergone previous percutaneous coronary intervention (PCI) remains a dilemma. Continuing dual antiplatelet therapy (DAPT) may carry a risk of bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::46fa6de9454f5881ea0af07ac2442ae7
https://eprints.whiterose.ac.uk/144427/1/1-s2.0-S0007091218308092-main.pdf
https://eprints.whiterose.ac.uk/144427/1/1-s2.0-S0007091218308092-main.pdf
Autor:
Fearnley, GW, Smith, GA, Abdul Zani, I, Yuldasheva, N, Mughal, NA, Homer-Vanniasinkam, S, Kearney, MT, Zachary, IC, Tomlinson, DC, Harrison, MA, Wheatcroft, SB, Ponnambalam, S
Publikováno v:
Biology Open, Vol 5, Iss 5, Pp 571-583 (2016)
Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can
Autor:
Smith, GA, Fearnley, G, Abdul Zani, I, Wheatcroft, SB, Tomlinson, DC, Harrison, MA, Ponnambalam, S
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1404-1415 (2017)
Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::076a84c031376a37b8197533e9e9e651
https://eprints.whiterose.ac.uk/120202/21/1404.full.pdf
https://eprints.whiterose.ac.uk/120202/21/1404.full.pdf
Publikováno v:
Biology Open, Vol 4, Iss 6, Pp 731-742 (2015)
Biology open
Biology open
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist but their physiological significance is unc
NOX2 NADPH-OXIDASE A NOVEL TARGET TO PREVENT INSULIN RESISTANCE RELATED ENDOTHELIAL CELL DYSFUNCTION
Autor:
Sukumar, P, Viswambharan, H, Imrie, H, Cubbon, RM, Yuldasheva, N, Gage, M, Galloway, S, Skromna, A, Smith, J, Gatenby, K, Beech, DJ, Wheatcroft, SB, Channon, KM, Shah, AM, Kearney, MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d620317bf8277259e25d7057ca679122
https://doi.org/10.1136/heartjnl-2012-301877b.105
https://doi.org/10.1136/heartjnl-2012-301877b.105
Autor:
Smith, GA, Fearnley, GW, Zani, IA, Wheatcroft, SB, Tomlinson, DC, Harrison, MA, Ponnambalam, S
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular function. VEGF-A binding to vascular endothelial growth factor receptor 2 (VEGFR2) stimulates endothelial signal transduction and regulates multiple cellular responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e82a36b1438e4ffa5d99190d9388fcd8
https://eprints.whiterose.ac.uk/90882/13/Smith_et_al-2016-Traffic.pdf
https://eprints.whiterose.ac.uk/90882/13/Smith_et_al-2016-Traffic.pdf