Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Whasil Lee"'
Autor:
Devon E. Anderson, Katherine G. Broun, Paromita Kundu, Xingyu Jing, Xiang Tang, Christopher Lu, Alexander Kotelsky, Sandeep Mannava, Whasil Lee
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: A massive rotator cuff tear (RCT) leads to glenohumeral joint destabilization and characteristic degenerative changes, termed cuff tear arthropathy (CTA). Understanding the response of articular cartilage to a massive RCT will elucidate
Externí odkaz:
https://doaj.org/article/74a2f6df186a4e72a9c57dc6560c8d99
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain. Chondrocytes in the cartilage are responsible for extracellular
Externí odkaz:
https://doaj.org/article/57fe20ee6d95468e97d72a6df018270f
Autor:
Alexander Kotelsky, Anissa Elahi, Can Nejat Yigit, Ashley Proctor, Sandeep Mannava, Christoph Pröschel, Whasil Lee
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 1, Pp 100227- (2022)
Objective: The objective of this study is to understand the role of altered in vivo mechanical environments in knee joints post anterior cruciate ligament (ACL)-injury in chondrocyte vulnerability against mechanical stimuli and in the progression of
Externí odkaz:
https://doaj.org/article/3e09d514a59f4ef8a748dfd6e6307aca
Autor:
David Fraser, Tram Nguyen, Alexander Kotelsky, Whasil Lee, Mark Buckley, Danielle S. W. Benoit
Publikováno v:
ACS Biomaterials Science & Engineering. 8:3568-3575
Cell and tissue alignment is a defining feature of periodontal tissues. Therefore, the development of scaffolds that can guide alignment of periodontal ligament cells (PDLCs) relative to tooth root (dentin) surfaces is highly relevant for periodontal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bcfb0c615efbc390699e8430265d14
https://doi.org/10.1021/acsbiomaterials.2c00566
https://doi.org/10.1021/acsbiomaterials.2c00566
Autor:
Whasil Lee
Publikováno v:
The Journal of Pain. 24:44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e161f12fa97230b3e95fd9eab1130f0a
https://doi.org/10.1016/j.jpain.2023.02.137
https://doi.org/10.1016/j.jpain.2023.02.137
ObjectiveThe objective of this study is to understand the role of altered in vivo mechanical environments in knee joints post anterior cruciate ligament (ACL)-injury in chondrocyte vulnerability against mechanical stimuli and in the progression of po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd3cb85034a4e6a2d0c02bc784723a4f
https://doi.org/10.1101/2021.06.16.448294
https://doi.org/10.1101/2021.06.16.448294
Autor:
Wolfgang Liedtke, Holly A. Leddy, Robert J. Nims, Qiaojuan Zhang, Alireza Savadipour, Whasil Lee, Yong Chen, Amy L. McNulty, Fang Liu, Farshid Guilak
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 118(13)
Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any disease-modifying therapies [A. M. Valdes, T. D. Spector, Nat. Rev. Rheumatol. 7, 23-32 (2011)]. We previously identified mechanosensitive PIEZO channels, PIEZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf1861699eafdd8678d3709b585d430
https://pubmed.ncbi.nlm.nih.gov/34163062
https://pubmed.ncbi.nlm.nih.gov/34163062
Autor:
Amy L. McNulty, Whasil Lee, Alireza Savadipour, Wolfgang Liedtke, Farshid Guilak, Fang Liu, Robert J. Nims, Holly A. Leddy, Yong Chen
Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any disease-modifying therapies (1, 2). We previously identified mechanosensitive PIEZO channels, PIEZO1 and PIEZO2, both expressed in articular cartilage, to func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a937a5d8586e046558ca96572e6d7f9b
https://doi.org/10.1101/2020.05.23.112565
https://doi.org/10.1101/2020.05.23.112565
Autor:
Whasil Lee, Quan Fang, Suk Hee Lee, Robert W. Gereau, Daniel S. Brenner, Patrick Kanju, Puja K. Parekh, Yong Chen, Fan Wang, Carlene Moore, Wolfgang Liedtke
Publikováno v:
Pain. 155:2662-2672
Detection of external irritants by head nociceptor neurons has deep evolutionary roots. Irritant-induced aversive behavior is a popular pain model in laboratory animals. It is used widely in the formalin model, where formaldehyde is injected into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66bd696f1c2391783938c0016b769ed
https://doi.org/10.1016/j.pain.2014.09.033
https://doi.org/10.1016/j.pain.2014.09.033
Cartilage is an intrinsically mechanically sensitive tissue composed of chondrocytes as the only cell type. Chondrocyte mechanotransduction is not well understood, but recently we identified critical components of the mechanotransduction machinery de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2625604ae6cd64ed52eec620f4f59eb8
https://doi.org/10.1016/bs.ctm.2016.10.003
https://doi.org/10.1016/bs.ctm.2016.10.003