Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Wha-Bin Im"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:546-552
Prodrugs of 5-aminosalicylic acid (5-ASA), such as sulfasalazine, have been the mainstay for the treatment and maintenance of inflammatory bowel disease (IBD) for decades, which is attributable to their antiadaptive immune activity. However, 5-ASA co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bb58d5fdf6aa37093c316204ca468e
https://doi.org/10.1124/jpet.110.173252
https://doi.org/10.1124/jpet.110.173252
Publikováno v:
Molecular Pharmacology. 64:78-84
The human 5-hydroxytryptamine-2C (5-HT2C) receptor has been the target of potential anxiolytics and antiobesity drugs, and its positive allosteric modulator was discovered to be l-threo-alpha-d-galacto-octopyranoside, methyl-7-chloro-6,7,8-trideoxy-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2432c226a51de6987c9a79b7bd0baca7
https://doi.org/10.1124/mol.64.1.78
https://doi.org/10.1124/mol.64.1.78
Publikováno v:
British Journal of Pharmacology. 138:427-434
The human 5-HT2C receptor, when expressed heterologously in various mammalian cell lines (HEK293, SH-EP and NIH-3T3) at various receptor densities (6 to 45 pmol mg−1 protein), mediates robust agonist-induced GTPγ35S binding from coupling to Gi sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526181caf2b74417fa8c6ef7675467a0
https://doi.org/10.1038/sj.bjp.0705058
https://doi.org/10.1038/sj.bjp.0705058
Publikováno v:
Neuroscience Letters. 334:49-52
The neuronal nicotinic acetylcholine receptor subunit, alpha7, can form homopentameric receptor/ion channel complexes. Potential contributions of its N-terminal region to homomeric interactions were investigated, in comparison with the corresponding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d7c16d2373fd8a27ed8f341853235f
https://doi.org/10.1016/s0304-3940(02)01068-6
https://doi.org/10.1016/s0304-3940(02)01068-6
Publikováno v:
European Journal of Pharmacology. 383:311-319
The 5-HT(2C) receptor as heterologously expressed in various mammalian cells mediates inositol 1,4,5-triphosphate (IP(3)) signal by activating G(q/11) subtypes of G proteins, but minimally promotes agonist-induced GTPgamma35S binding in membranes due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e2b05bc0d41ba06d56c2e5031c00f0
https://doi.org/10.1016/s0014-2999(99)00653-6
https://doi.org/10.1016/s0014-2999(99)00653-6
Autor:
Jeffrey F Pregenzer, Wha Bin Im, Glen L Alberts, Ennis Michael D, Robert Louis Hoffman, Tenbrink Ruth E, Jerry L. Slightom, Nabil B. Ghazal
Publikováno v:
British Journal of Pharmacology. 127:468-472
Both the 5-HT1D and 5-HT1B receptors are implicated in migraine pathophysiology. Recently isochromans have been discovered to bind primate 5-HT1D receptors with much higher affinity than 5-HT1B receptors. In the guinea-pig, a primary animal model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe6ffa9681aa3bf271d60dc3bbb8e48e
https://doi.org/10.1038/sj.bjp.0702532
https://doi.org/10.1038/sj.bjp.0702532
Publikováno v:
British Journal of Pharmacology. 125:705-710
1 Cysteine 114 (C114) of the human dopamine D3 receptor is located at the helical face of transmembrane segment III (TMIII) near aspartate 110, a counterion for the amine group of catecholamines. The contributions of C114 to receptor function were in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e73680c34be093c97af3c974ec86d6cf
https://doi.org/10.1038/sj.bjp.0702136
https://doi.org/10.1038/sj.bjp.0702136
Publikováno v:
Molecular Pharmacology. 54:379-388
To investigate the roles of individual transmembrane segments (TM) of the human D3 dopamine receptor in its ligand-receptor interactions, we generated chimeric receptors in which its TMs were replaced, one at a time, partially or entirely, by the cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424093d6159f99edbb2ad5807532886f
https://doi.org/10.1124/mol.54.2.379
https://doi.org/10.1124/mol.54.2.379
Autor:
Robert B. McCall, Wha Bin Im, Kjell Svensson, Nabil B. Ghazal, Jeffrey F Pregenzer, Lorri T. Harris, Robert Louis Hoffman, Ennis Michael D, Lawson Cf, Martin W. Smith, Dorothy M. Sutter, Richard A. Lewis, Schlachter Sk, Edward D. Hall
Publikováno v:
Journal of Medicinal Chemistry. 41:2180-2183
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3133ab586e8dce3e9c8b2da3ae17c0dc
https://doi.org/10.1021/jm980137o
https://doi.org/10.1021/jm980137o
Autor:
Wha Bin Im, H. K. Im, Jeffrey F Pregenzer, E. Jon Jacobsen, Nancy C. Stratman, Philip F. VonVoigtlander
Publikováno v:
British Journal of Pharmacology. 123:1490-1494
Imidazoquinoxaline PNU-97775 and imidazoquinoline PNU-101017 are benzodiazepine site ligands with a second low affinity binding site on GABAA receptors, the occupancy of which at high drug concentrations reverses their positive allosteric activity vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc8685fa1d3a89512c7210dddb4e82a2
https://doi.org/10.1038/sj.bjp.0701763
https://doi.org/10.1038/sj.bjp.0701763