Výsledky vyhledávání

P1-17-01: Figitumumab Plus Exemestane Versus Exemestane as First-Line Treatment of Postmenopausal Hormone Receptor-Positive Advanced Breast Cancer: A Randomized, Open-Label Phase II Trial

Autor: D Fenton, RJ Benner, SJ Meech, Paula D. Ryan, Patrick Neven, B Sleight, Carlos Barrios, D Yee, Paul E. Goss, Luc Dirix, Kimberly L. Blackwell, Luis Fein, WH Miller, L Paccagnella

Publikováno v: Cancer Research. 71:P1-17

Background Figitumumab (CP-751,871) is a fully human IgG2 monoclonal antibody that inhibits IGF-1R. Exemestane profoundly reduces estrogen production and has activity as first-line treatment in postmenopausal metastatic hormone receptor-positive (HR+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7ed3049e62e48fe7ba2d38593110622
https://doi.org/10.1158/0008-5472.sabcs11-p1-17-01

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Correlation of ASTM Method D 2887-73 Boiling Range Distribution Data with ASTM Method D 86-67 Distillation Data

Autor: R Wertzler, WH Miller, DC Ford, RC Thren

This paper describes two proposed methods of predicting ASTM Test for Distillation of Petroleum Products (D 86-67) and ASTM Test for Distillation of Petroleum Products at Reduced Pressure (D 1160-61) data from ASTM Test for Boiling Range Distribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8e742db7b54ebf5ab8723938307ed6f
https://doi.org/10.1520/stp35520s

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Estrogen receptor expression activates the transcriptional and growth-inhibitory response to retinoids without enhanced retinoic acid receptor alpha expression

Autor: Rosenauer A, Clara NERVI, Davison K, Ww, Lamph, Mader S, Wh, Miller Jr

Publikováno v: Europe PubMed Central

Estrogen receptor (ER)-positive human breast cancer cells are hormonally regulated and are inhibited by retinoids, whereas most ER-negative breast cancer cells are not. Here, we compared retinoid-induced transcriptional activation and growth inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::756678e3dfca48924461c888f14675fb
https://pubmed.ncbi.nlm.nih.gov/9823320

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A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation

Autor: Shao W, Benedetti L, Ww, Lamph, Clara NERVI, Wh, Miller Jr

Publikováno v: Europe PubMed Central

The unique t(15;17) of acute promyelocytic leukemia (APL) fuses the PML gene with the retinoic acid receptor alpha (RAR alpha) gene. Although retinoic acid (RA) inhibits cell growth and induces differentiation in human APL cells, resistance to RA dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d00027f38ef69315debc96f7ff4478a4
https://pubmed.ncbi.nlm.nih.gov/9192750

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Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)

Autor: Jd, Licht, Christine CHOMIENNE, Goy A, Chen A, Aa, Scott, Dr, Head, Jl, Michaux, Wu Y, DeBlasio A, Wh, Miller

Publikováno v: Europe PubMed Central

Analysis of a variant translocation t(11;17) in a case of acute promyelocytic leukemia (APL) led to discovery of a novel zinc finger gene, PLZF, fused to the retinoic acid receptor-alpha (RAR alpha) gene. We reviewed the clinical and molecular featur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0de64a9db060ea1005e56d08070976d7
https://pubmed.ncbi.nlm.nih.gov/7849296

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Safety of the anti-IGF-1R antibody CP-751,871 in combination with exemestane in patients with advanced breast cancer

Autor: Paul E. Goss, Carlos H. Barrios, D Fenton, MF Abraham, Paula D. Ryan, LY Dirix, WH Miller, A Gualberto, L Paccagnella, Patrick Neven

Publikováno v: Cancer Research. 69:2136

Abstract #2136 Background: Aromatase inhibitors (AIs) are established first-line treatment for postmenopausal estrogen receptor (ER)+ metastatic breast cancer. However, not all patients benefit from AIs and those whose tumors initially respond eventu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7b7eae0be45e65e7ceeacf6e766a289
https://doi.org/10.1158/0008-5472.sabcs-2136

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Altered ligand binding and transcriptional regulation by mutations in the PML/RARalpha ligand-binding domain arising in retinoic acid-resistant patients with acute promyelocytic leukemia

Autor: Côté S, Zhou D, Bianchini A, Clara NERVI, Re, Gallagher, Wh, Miller Jr

Publikováno v: Europe PubMed Central

Acute promyelocytic leukemia (APL) is characterized by a specific translocation, t(15;17), that fuses the promyelocytic leukemia (PML) gene with the RA receptor RARalpha. Pharmacologic doses of retinoic acid (RA) induce differentiation in human APL c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::58a451af977f2bdf69ac007fbf6e90f0
http://europepmc.org/abstract/med/11050004

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