Výsledky vyhledávání - "Wey-Cheng Sim"

Akademický článek

Analysis of Genetic Variation in CYP450 Genes for Clinical Implementation.

Autor: Liuh Ling Goh, Chia Wei Lim, Wey Cheng Sim, Li Xian Toh, Khai Pang Leong

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169233 (2017)

Genetic determinants of drug response remain stable throughout life and offer great promise to patient-tailored drug therapy. The adoption of pharmacogenetic (PGx) testing in patient care requires accurate, cost effective and rapid genotyping with cl

Externí odkaz: https://doaj.org/article/dd60f2fe08e7486aad2899d1c18031e4

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The heparan sulfate proteoglycan syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase—Wnt signaling axis

Autor: Valeria Tria, Rolland Reinbold, George W. Yip, Wey-Cheng Sim, Sherif Abdelaziz Ibrahim, Ileana Zucchi, Burkhard Greve, Sampath Kumar Katakam, Theodoros Karnavas, Martin Götte, Stefano Molgora, Paride Pelucchi, Eleonora Piscitelli, Eslam A. El-Ghonaimy

Publikováno v: The FEBS Journal
The FEBS journal
(2020). doi:10.1111/febs.15356
info:cnr-pdr/source/autori:Katakam, Sampath Kumar; Tria, Valeria; Sim, Wey-Cheng; Yip, George W.; Molgora, Stefano; Karnavas, Theodoros; Elghonaimy, Eslam A.; Pelucchi, Paride; Piscitelli, Eleonora; Ibrahim, Sherif Abdelaziz; Zucchi, Ileana; Reinbold, Rolland; Greve, Burkhard; Goette, Martin/titolo:The heparan sulfate proteoglycan syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase-Wnt signaling axis/doi:10.1111%2Ffebs.15356/rivista:The FEBS journal (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

In colon cancer, downregulation of the transmembrane heparan sulfate proteoglycan syndecan-1 (Sdc-1) is associated with increased invasiveness, metastasis, and dedifferentiation. As Sdc-1 modulates signaling pathways relevant to stem cell function, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ea4b24fab851ea7f018baf542f61c0
https://doi.org/10.1111/febs.15356

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Validation of a next generation sequencing assay for BRCA1, BRCA2, CHEK2 and PALB2 genetic testing

Autor: Wey Cheng Sim, Liuh Ling Goh, Karolien Bettens, Chee Yang Lee, Violaine Mottier, Rebecca Richards

Publikováno v: Experimental and molecular pathology. 116

BRCA1, BRCA2, CHEK2 and PALB2 genes are associated with hereditary breast and ovarian cancer syndrome. Genetic testing of these genes is of increasing importance to guide therapeutic and management decisions. In this study, we evaluated the performan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19046c6724a26ec7ee2862618f764ce
https://pubmed.ncbi.nlm.nih.gov/32531196

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Non-invasive detection of actionable mutations in advanced non-small-cell lung cancer using targeted sequencing of circulating tumor DNA

Autor: Grace Li Xian Toh, Chet Hong Loh, Liuh Ling Goh, Akhil Chopra, Wey Cheng Sim, Chia Wei Lim, Alex Yuan Chi Chang

Publikováno v: Lung cancer (Amsterdam, Netherlands). 124

Objective To evaluate the feasibility of detecting actionable gene mutations in circulating tumor DNA (ctDNA) in patients with advanced non-small-cell lung cancer (NSCLC) using targeted next-generation sequencing (NGS). Materials and methods In total

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7054ccf8b481d715fca452319c902ee
https://pubmed.ncbi.nlm.nih.gov/30268455

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Analysis of Genetic Variation in CYP450 Genes for Clinical Implementation

Autor: Khai Pang Leong, Wey Cheng Sim, Li Xian Toh, Chia Wei Lim, Liuh Ling Goh

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169233 (2017)
PLoS ONE

Background Genetic determinants of drug response remain stable throughout life and offer great promise to patient-tailored drug therapy. The adoption of pharmacogenetic (PGx) testing in patient care requires accurate, cost effective and rapid genotyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f6bf7abe771aa25ff431cd78644e24
http://europepmc.org/articles/PMC5207784?pdf=render

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Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore

Autor: Degang Wu, Jinzhuang Dou, Xiaoran Chai, Claire Bellis, Andreas Wilm, Chih Chuan Shih, Wendy Wei Jia Soon, Nicolas Bertin, Clarabelle Bitong Lin, Chiea Chuen Khor, Michael DeGiorgio, Shanshan Cheng, Li Bao, Neerja Karnani, William Ying Khee Hwang, Sonia Davila, Patrick Tan, Asim Shabbir, Angela Moh, Eng-King Tan, Jia Nee Foo, Liuh Ling Goh, Khai Pang Leong, Roger S.Y. Foo, Carolyn Su Ping Lam, Arthur Mark Richards, Ching-Yu Cheng, Tin Aung, Tien Yin Wong, Huck Hui Ng, Jianjun Liu, Chaolong Wang, Matthew Andrew Ackers-Johnson, Edita Aliwarga, Kenneth Hon Kim Ban, Denis Bertrand, John C. Chambers, Dana Leng Hui Chan, Cheryl Xue Li Chan, Miao Li Chee, Miao Ling Chee, Pauline Chen, Yunxin Chen, Elaine Guo Yan Chew, Wen Jie Chew, Lynn Hui Yun Chiam, Jenny Pek Ching Chong, Ivan Chua, Stuart A. Cook, Wei Dai, Rajkumar Dorajoo, Chuan-Sheng Foo, Rick Siow Mong Goh, Axel M. Hillmer, Ishak D. Irwan, Fazlur Jaufeerally, Asif Javed, Justin Jeyakani, John Tat Hung Koh, Jia Yu Koh, Pavitra Krishnaswamy, Jyn Ling Kuan, Neelam Kumari, Ai Shan Lee, Seow Eng Lee, Sheldon Lee, Yen Ling Lee, See Ting Leong, Zheng Li, Peter Yiqing Li, Jun Xian Liew, Oi Wah Liew, Su Chi Lim, Weng Khong Lim, Chia Wei Lim, Tingsen Benson Lim, Choon Kiat Lim, Seet Yoong Loh, Au Wing Lok, Calvin W.L. Chin, Shivani Majithia, Sebastian Maurer-Stroh, Wee Yang Meah, Shi Qi Mok, Niranjan Nargarajan, Pauline Ng, Sarah B. Ng, Zhenyuan Ng, Jessica Yan Xia Ng, Ebonne Ng, Shi Ling Ng, Simon Nusinovici, Chin Thing Ong, Bangfen Pan, Vincent Pedergnana, Stanley Poh, Shyam Prabhakar, Kumar M. Prakash, Ivy Quek, Charumathi Sabanayagam, Wei Qiang See, Yee Yen Sia, Xueling Sim, Wey Cheng Sim, Jimmy So, Dinna K.N. Soon, E. Shyong Tai, Nicholas Y. Tan, Louis C.S. Tan, Hong Chang Tan, Wilson Lek Wen Tan, Moses Tandiono, Amanda Tay, Sahil Thakur, Yih Chung Tham, Zenia Tiang, Grace Li-Xian Toh, Pi Kuang Tsai, Lavanya Veeravalli, Chandra S. Verma, Ling Wang, Min Rui Wang, Wing-Cheong Wong, Zhicheng Xie, Khung Keong Yeo, Liang Zhang, Weiwei Zhai, Yi Zhao

Publikováno v: Cell, 179(3), 736-749.e15. CELL PRESS

Underrepresentation of Asian genomes has hindered population and medical genetics research on Asians, leading to population disparities in precision medicine. By whole-genome sequencing of 4,810 Singapore Chinese, Malays, and Indians, we found 98.3 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fc6f1f77725c9278d94850e16244b8
https://hdl.handle.net/11370/91129d3f-e884-4e42-a172-38209156be75

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Syndecan-1 is a potential biomarker for triple-positive breast carcinomas in Asian women with correlation to survival

Autor: Puay Hoon Tan, Ana Richelia Jara-Lazaro, Geok Hoon Lim, Aye Aye Thike, George W. Yip, Wey-Cheng Sim, Von-Bing Yap

Publikováno v: Singapore medical journal. 55(9)

Introduction While overexpression of syndecan-1 has been associated with aggressive breast cancer in the Caucasian population, the expression pattern of syndecan-1 in Asian women remains unclear. Triple-positive breast carcinoma, in particular, is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51517d9e1f9dcd98264daed5127ebbb
https://pubmed.ncbi.nlm.nih.gov/25273930

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