Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling.

Autor: van Hoogdalem MW; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45229, USA., Tanaka R; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Abduljalil K; Certara UK Limited, Simcyp Division, Sheffield S1 2BJ, UK., Johnson TN; Certara UK Limited, Simcyp Division, Sheffield S1 2BJ, UK., Wexelblatt SL; Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA., Akinbi HT; Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA., Vinks AA; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA., Mizuno T; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.

Publikováno v: Pharmaceutics [Pharmaceutics] 2024 Mar 08; Vol. 16 (3). Date of Electronic Publication: 2024 Mar 08.

Rates of substance and polysubstance use through universal maternal testing at the time of delivery.

Autor: Smith BL; Department of Pharmacology & Systems Physiology, University of Cincinnati Reading Campus, Cincinnati, OH, USA., Hall ES; Translational Data Science and Informatics, Geisinger, Danville, PA, USA.; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., McAllister JM; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Marcotte MP; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of OB GYN, division of Maternal Fetal Medicine, TriHealth, Cincinnati, OH, USA., Setchell KDR; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Pathology and Laboratory Medicine, Clinical Mass Spectrometry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Megaraj V; Division of Pathology and Laboratory Medicine, Clinical Mass Spectrometry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Jimenez KL; Division of Pathology and Laboratory Medicine, Clinical Mass Spectrometry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., John Winhusen T; Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Wexelblatt SL; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. scott.wexelblatt@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. scott.wexelblatt@cchmc.org.; Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA. scott.wexelblatt@cchmc.org.

Publikováno v: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2022 Aug; Vol. 42 (8), pp. 1026-1031. Date of Electronic Publication: 2022 Feb 17.

Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome.

Autor: van Hoogdalem MW; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA., Johnson TN; Certara UK Limited, Sheffield, UK., McPhail BT; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; School of Medicine Greenville, University of South Carolina, Greenville, South Carolina, USA., Kamatkar S; Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Community Hospital East, Indianapolis, Indiana, USA., Wexelblatt SL; Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA., Ward LP; Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA., Christians U; iC42 Clinical Research and Development, University of Colorado, Aurora, Colorado, USA., Akinbi HT; Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA., Vinks AA; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA., Mizuno T; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Feb; Vol. 111 (2), pp. 496-508. Date of Electronic Publication: 2021 Nov 21.

Pharmacotherapy of neonatal opioid withdrawal syndrome: a review of pharmacokinetics and pharmacodynamics.

Autor: van Hoogdalem MW; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; James L. Winkle College of Pharmacy, University of Cincinnati , Cincinnati, OH, USA., McPhail BT; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; School of Medicine Greenville, University of South Carolina , Greenville, SC, USA., Hahn D; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA., Wexelblatt SL; Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati , Cincinnati, OH, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati , Cincinnati, OH, USA., Akinbi HT; Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati , Cincinnati, OH, USA., Vinks AA; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati , Cincinnati, OH, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati , Cincinnati, OH, USA., Mizuno T; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati , Cincinnati, OH, USA.; Center for Addiction Research, College of Medicine, University of Cincinnati , Cincinnati, OH, USA.

Publikováno v: Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2021 Jan; Vol. 17 (1), pp. 87-103. Date of Electronic Publication: 2020 Oct 29.

Addressing the Disease Burden of Vertically Acquired Hepatitis C Virus Infection Among Opioid-Exposed Infants.

Autor: Protopapas S; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Murrison LB; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Wexelblatt SL; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Blackard JT; Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Hall ES; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Publikováno v: Open forum infectious diseases [Open Forum Infect Dis] 2019 Oct 21; Vol. 6 (12), pp. ofz448. Date of Electronic Publication: 2019 Oct 21 (Print Publication: 2019).