Výsledky vyhledávání - "Wetzel, Andrea"

Akademický článek

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Dissertation/ Thesis

The role of TrkB and NaV1.9 in activity-dependent axon growth in motoneurons

Autor: Wetzel, Andrea

Während der Entwicklung des Nervensystems lassen sich bei Motoneuronen aktivitätsabhängige Kalziumströme eobachten, die das Axonwachstum regulieren. Diese Form der neuronalen Spontanaktivität sowie das Auswachsen von Axonen sind bei Motoneuronen

Externí odkaz: https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/9287
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-92877
https://opus.bibliothek.uni-wuerzburg.de/files/9287/Andrea_Wetzel_Disseration.pdf

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Periodical

Warum heute im Vertrieb agiles Arbeiten wichtig ist.

Autor: Wetzel, Andrea

Publikováno v: Changement. Mar2023, Issue 2, p24-27. 4p.

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Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease

Autor: Petrache, Alexandra L, Rajulawalla, Aarib, Shi, Anqi, Wetzel, Andrea, Saito, Takashi, Saido, Takaomi C, Harvey, Kirsten, Ali, Afia B

Publikováno v: Cerebral Cortex (New York, NY)

Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration observed in Alzheimer’s disease (AD). We hypothesize that the initial insult originates in the lateral entorhinal cortex (LEC) due to deficits in key inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e310cea4b3279111c5b605d537741f97
http://europepmc.org/articles/PMC6418384

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Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

Autor: Pellegrini, Laura, Hauser, David N, Li, Yan, Mamais, Adamantios, Beilina, Alexandra, Kumaran, Ravindran, Wetzel, Andrea, Nixon-Abell, Jonathon, Heaton, George, Rudenko, Iakov, Alkaslasi, Mor, Ivanina, Natalie, Melrose, Heather L, Cookson, Mark R, Harvey, Kirsten

Publikováno v: Human Molecular Genetics

Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson’s disease (PD) and genetic variation around LRRK2 contributes to risk of sporadic disease. Although knockout (KO) of Lrrk2 or knock-in of pathogenic mutations into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f9d83bc1ca861684f53df26b43fc082
http://europepmc.org/articles/PMC6121185

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Akademický článek

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Pathogenic LRRK2 variants are gain-of function mutations that enhance LRRK2-mediated repression of β-catenin signaling

Autor: Berwick, Daniel C., Javaheri, Behzad, Wetzel, Andrea, Hopkinson, Mark, Nixon-Abell, Jonathon, Granno, Simone, Pitsillides, Andrew A., Harvey, Kirsten

BackgroundLRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson’s disease, while recent studies have identified potential protective variants. This, and the fact that LRRK2 mutation carriers develop symptom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::704a7e5dbed8bf6ed97ee8303b4ad1bf
http://oro.open.ac.uk/48245/2/art%3A10.1186%2Fs13024-017-0153-4.pdf

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Additional file 4: Figure S3. of Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

Autor: Berwick, Daniel, Javaheri, Behzad, Wetzel, Andrea, Hopkinson, Mark, Nixon-Abell, Jonathon, Grannò, Simone, Pitsillides, Andrew, Harvey, Kirsten

Increased canonical Wnt activity in Lrrk2 knockout cells. A, B) Cells were transfected with TK-renilla and TOPflash or FOPflash in the presence of A) FLAG-DVl1 or C) GFP-FZD5 and HA-LRP6, or appropriate vector controls. A) 1-way ANOVA (n = 9; F = 146

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc1a4ebda7b11ec605bf72be5e043266

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Additional file 5: Figure S4. of Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

Autor: Berwick, Daniel, Javaheri, Behzad, Wetzel, Andrea, Hopkinson, Mark, Nixon-Abell, Jonathon, Grannò, Simone, Pitsillides, Andrew, Harvey, Kirsten

Association of mycLRRK2 and FLAG-β-catenin in HEK293 cells 24 h post transfection, cells expressing myc-tagged LRRK2 and FLAG-tagged β-catenin were treated with MG132 for 1 h to allow β-catenin accumulation. The cells were subsequently fixed and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1753df50e8a484b01dee74c079c78e66

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Additional file 3: Figure S2. of Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

Autor: Berwick, Daniel, Javaheri, Behzad, Wetzel, Andrea, Hopkinson, Mark, Nixon-Abell, Jonathon, Grannò, Simone, Pitsillides, Andrew, Harvey, Kirsten

Effects of loss of Lrrk2 on tibial cortical Zmax and Zmin. Images in Figures A and B show i) values for Zmax and Zmin, predicted resistance to fracture along the shortest and longest cross-sectional axes, respectively in female wild-type (WT) and Lrr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1d1302f2bbffa979e8072a054c2b328

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