Výsledky vyhledávání - "Westwick, J K"

Oncogenic ras induces gastrin gene expression in colon cancer

Autor: Westwick, J. K., Tillotson, L. G., Nakata, H., Chung, D. C., Wang, S. L.

Background & Aims: The expression of gastrin, as a tumor growth factor, is significantly increased in some colon cancers compared with the low levels found in normal mucosa. The aim of this study was to elucidate the transcriptional mechanisms of gas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e11d2fc4d11c5ed2e5b1c33a616688a

Zobrazit plný text záznamu

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

Autor: Van Aelst, L, Westwick, J K, Der, C J, Pestell, R G, Clark, G J, Symons, M, Lambert, Q T

Rac1 and RhoA are members of the Rho family of Ras-related proteins and function as regulators of actin cytoskeletal organization, gene expression, and cell cycle progression. Constitutive activation of Rac1 and RhoA causes tumorigenic transformation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e44a7c1838b16cd43c8c8c6d6e9edbf

Zobrazit plný text záznamu

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

Autor: Khosravi-Far, R., White, M. A., Westwick, J. K., Solski, P. A., Chrzanowska-Wodnicka, M., Aelst, L., Michael Wigler, Der, C.J.

Publikováno v: Scopus-Elsevier

Substantial evidence supports a critical role for the activation of the Raf-1/MEK/mitogen-activated protein kinase pathway in oncogenic Ras-mediated transformation. For example, dominant negative mutants of Raf-1, MEK, and mitogen-activated protein k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a6bf9139d2d1610a5516b5bc09af8c

Zobrazit plný text záznamu

Ceramide Activates the Stress-activated Protein Kinases

Autor: Westwick, J. K., Hannun, Y. A., Dbaibo, G., Bielawska, A. E., Brenner, D. A.

Tumor necrosis factor alpha (TNF alpha) activates the stress-activated protein kinases (SAPKs, also known as Jun nuclear kinases or JNKs) resulting in the stimulation of AP-1-dependent gene transcription and induces the translocation of NF kappa B to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::820b0deedd92dee6eb08c4b8c6e2b3b5

Zobrazit plný text záznamu

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

Autor: Cox, A. D., Westwick, J. K., Brenner, D. A., Hibi, M., Karin, M., Der, C. J., Cobb, M. H.

c-Jun transcriptional activity is augmented by expression of oncogenic Ras and Raf proteins. This study demonstrates a direct correlation between Ras transforming activity and c-Jun activation, supporting an important role for c-Jun in transformation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3535083b3b22dfc724895cdf73590c86

Zobrazit plný text záznamu

Akademický článek

Activation of activating protein 1 during hepatic acute phase response.

Autor: HATTORI, M., TUGORES, A., WESTWICK, J. K., VELOZ, L., LEFFERT, H. L., KARIN, M., BRENNER, D. A.

Publikováno v: American Journal of Physiology: Gastrointestinal & Liver Physiology; 1993, Vol. 27 Issue 1, p95-103, 9p

Zobrazit plný text záznamu

Periodical

Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway.

Autor: Joyce, D, Bouzahzah, B, Fu, M, Albanese, C, D'Amico, M, Steer, J, Klein, J U, Lee, R J, Segall, J E, Westwick, J K, Der, C J, Pestell, R G

Publikováno v: Journal of Biological Chemistry; September 1999, Vol. 274 Issue: 36 p25245-9, 5p

Zobrazit plný text záznamu

Periodical

Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun.

Autor: Westwick, J K, Lee, R J, Lambert, Q T, Symons, M, Pestell, R G, Der, C J, Whitehead, I P

Publikováno v: Journal of Biological Chemistry; July 1998, Vol. 273 Issue: 27 p16739-47, 9p

Zobrazit plný text záznamu

Periodical

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation.

Autor: Finco, T S, Westwick, J K, Norris, J L, Beg, A A, Der, C J, Baldwin, A S

Publikováno v: Journal of Biological Chemistry; September 1997, Vol. 272 Issue: 39 p24113-6, 4p

Zobrazit plný text záznamu

Periodical

Ceramide activates the stress-activated protein kinases.

Autor: Westwick, J K, Bielawska, A E, Dbaibo, G, Hannun, Y A, Brenner, D A

Publikováno v: Journal of Biological Chemistry; September 1995, Vol. 270 Issue: 39 p22689-92, 4p

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání