Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Westphal MV"'
Autor:
Mason JW; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA.; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Chow YT; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Hudson L; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA.; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Tutter A; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Michaud G; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Westphal MV; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA.; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Shu W; Structural and Biophysical Chemistry, Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Ma X; Structural and Biophysical Chemistry, Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Tan ZY; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Coley CW; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA., Clemons PA; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA., Bonazzi S; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Berst F; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland., Briner K; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Liu S; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA. sliu.broad@gmail.com.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. sliu.broad@gmail.com., Zécri FJ; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA, USA. frederic.zecri@novartis.com., Schreiber SL; Chemical Biology and Therapeutics Science, Broad Institute, Cambridge, MA, USA. stuart_schreiber@harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. stuart_schreiber@harvard.edu.
Publikováno v:
Nature chemical biology [Nat Chem Biol] 2024 Feb; Vol. 20 (2), pp. 170-179. Date of Electronic Publication: 2023 Nov 02.
Autor:
Hudson L; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Mason JW; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Westphal MV; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Richter MJR; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Thielman JR; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Hua BK; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Gerry CJ; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Xia G; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Osswald HL; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Knapp JM; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Tan ZY; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Kokkonda P; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Tresco BIC; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Liu S; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA., Reidenbach AG; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Lim KS; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Poirier J; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Capece J; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Bonazzi S; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Gampe CM; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Smith NJ; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Bradner JE; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Coley CW; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Department of Chemical Engineering, MIT, Cambridge, MA, 02139, USA., Clemons PA; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Melillo B; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Hon CS; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Ottl J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4002, Basel, Switzerland., Dumelin CE; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4002, Basel, Switzerland., Schaefer JV; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4002, Basel, Switzerland., Faust AME; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Berst F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4002, Basel, Switzerland., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA., Zécri FJ; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA. frederic.zecri@novartis.com., Briner K; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Publikováno v:
Nature communications [Nat Commun] 2023 Nov 21; Vol. 14 (1), pp. 7589. Date of Electronic Publication: 2023 Nov 21.
Autor:
Hudson L; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Mason JW; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Westphal MV; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Richter MJR; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Thielman JR; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Hua BK; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Gerry CJ; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Xia G; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Osswald HL; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Knapp JM; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Tan ZY; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Kokkonda P; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Tresco BIC; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Liu S; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA., Reidenbach AG; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Lim KS; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Poirier J; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Capece J; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Bonazzi S; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Gampe CM; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Smith NJ; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Bradner JE; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Coley CW; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Department of Chemical Engineering, MIT, Cambridge, MA, 02139, USA., Clemons PA; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Melillo B; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Hon CS; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA., Ottl J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4002, Basel, Switzerland., Dumelin CE; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4002, Basel, Switzerland., Schaefer JV; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4002, Basel, Switzerland., Faust AME; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Berst F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4002, Basel, Switzerland., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA., Zécri FJ; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA. frederic.zecri@novartis.com., Briner K; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Publikováno v:
Nature communications [Nat Commun] 2023 Aug 15; Vol. 14 (1), pp. 4930. Date of Electronic Publication: 2023 Aug 15.
Autor:
Ruiz de Martín Esteban S; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain., Benito-Cuesta I; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain., Terradillos I; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, Leioa, Spain., Martínez-Relimpio AM; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain., Arnanz MA; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain., Ruiz-Pérez G; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain., Korn C; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Raposo C; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Sarott RC; Laboratorium Für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland., Westphal MV; Laboratorium Für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland., Elezgarai I; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, Leioa, Spain., Carreira EM; Laboratorium Für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland., Hillard CJ; Department of Pharmacology and Toxicology, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, United States., Grether U; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Grandes P; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, Leioa, Spain., Grande MT; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain., Romero J; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain.
Publikováno v:
Frontiers in pharmacology [Front Pharmacol] 2022 Apr 27; Vol. 13, pp. 841766. Date of Electronic Publication: 2022 Apr 27 (Print Publication: 2022).
Autor:
Gazzi T; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de., Brennecke B; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de., Atz K; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Korn C; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Sykes D; Faculty of Medicine & Health Sciences, University of Nottingham Nottingham NG7 2UH England UK.; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham Midlands England UK., Forn-Cuni G; Leiden University Einsteinweg 55 2333 CC Leiden the Netherlands., Pfaff P; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland., Sarott RC; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland., Westphal MV; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland., Mostinski Y; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de., Mach L; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de., Wasinska-Kalwa M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de., Weise M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de., Hoare BL; Faculty of Medicine & Health Sciences, University of Nottingham Nottingham NG7 2UH England UK.; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham Midlands England UK., Miljuš T; Faculty of Medicine & Health Sciences, University of Nottingham Nottingham NG7 2UH England UK.; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham Midlands England UK., Mexi M; Faculty of Medicine & Health Sciences, University of Nottingham Nottingham NG7 2UH England UK.; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham Midlands England UK., Roth N; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London London EC1M 6BQ England UK., Koers EJ; Faculty of Medicine & Health Sciences, University of Nottingham Nottingham NG7 2UH England UK.; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham Midlands England UK., Guba W; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Alker A; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Rufer AC; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Kusznir EA; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Huber S; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Raposo C; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Zirwes EA; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Osterwald A; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Pavlovic A; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Moes S; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Beck J; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Nettekoven M; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Benito-Cuesta I; Faculty of Experimental Sciences, Universidad Francisco de Vitoria Pozuelo de Alarcón 28223 Madrid Spain., Grande T; Faculty of Experimental Sciences, Universidad Francisco de Vitoria Pozuelo de Alarcón 28223 Madrid Spain., Drawnel F; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Widmer G; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Holzer D; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., van der Wel T; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University 2333 CC Leiden the Netherlands., Mandhair H; Institute of Biochemistry and Molecular Medicine, University of Bern 3012 Bern Switzerland., Honer M; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Fingerle J; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Scheffel J; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin Berlin Germany.; Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Berlin Germany., Broichhagen J; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de., Gawrisch K; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health Rockville MD 20852 USA., Romero J; Faculty of Experimental Sciences, Universidad Francisco de Vitoria Pozuelo de Alarcón 28223 Madrid Spain., Hillard CJ; Department of Pharmacology and Toxicology, Neuroscience Research Center, Medical College of Wisconsin Milwaukee WI 53226 USA., Varga ZV; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health Rockville MD 20852 USA.; HCEMM-SU Cardiometabolic Immunology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University 1085 Budapest Hungary., van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University 2333 CC Leiden the Netherlands., Pacher P; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health Rockville MD 20852 USA., Gertsch J; Institute of Biochemistry and Molecular Medicine, University of Bern 3012 Bern Switzerland., Ullmer C; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., McCormick PJ; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London London EC1M 6BQ England UK., Oddi S; Faculty of Veterinary Medicine, University of Teramo 64100 Teramo European Italy.; European Center for Brain Research (CERC), Santa Lucia Foundation 00179 Rome Italy., Spaink HP; Leiden University Einsteinweg 55 2333 CC Leiden the Netherlands., Maccarrone M; European Center for Brain Research (CERC), Santa Lucia Foundation 00179 Rome Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila 67100 L'Aquila Italy., Veprintsev DB; Faculty of Medicine & Health Sciences, University of Nottingham Nottingham NG7 2UH England UK.; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham Midlands England UK., Carreira EM; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland., Grether U; Roche Pharma Research & Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. 4070 Basel Switzerland uwe.grether@roche.com., Nazaré M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de.
Publikováno v:
Chemical science [Chem Sci] 2022 Apr 01; Vol. 13 (19), pp. 5539-5545. Date of Electronic Publication: 2022 Apr 01 (Print Publication: 2022).
Autor:
Sarott RC; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Westphal MV; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Pfaff P; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Korn C; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Sykes DA; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands B15 2TT, U.K., Gazzi T; Leibniz-Institut für Molekulare Pharmakologie FMP, Campus Berlin-Buch, 13125 Berlin, Germany., Brennecke B; Leibniz-Institut für Molekulare Pharmakologie FMP, Campus Berlin-Buch, 13125 Berlin, Germany., Atz K; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Weise M; Leibniz-Institut für Molekulare Pharmakologie FMP, Campus Berlin-Buch, 13125 Berlin, Germany., Mostinski Y; Leibniz-Institut für Molekulare Pharmakologie FMP, Campus Berlin-Buch, 13125 Berlin, Germany., Hompluem P; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands B15 2TT, U.K., Koers E; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands B15 2TT, U.K., Miljuš T; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands B15 2TT, U.K., Roth NJ; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, England., Asmelash H; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, England., Vong MC; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands B15 2TT, U.K., Piovesan J; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands B15 2TT, U.K., Guba W; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Rufer AC; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Kusznir EA; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Huber S; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Raposo C; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Zirwes EA; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Osterwald A; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Pavlovic A; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Moes S; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Beck J; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Benito-Cuesta I; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223, Madrid, Spain., Grande T; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223, Madrid, Spain., Ruiz de Martı N Esteban S; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223, Madrid, Spain., Yeliseev A; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, United States., Drawnel F; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Widmer G; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Holzer D; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., van der Wel T; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, 2333 CC, Leiden, The Netherlands., Mandhair H; Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland., Yuan CY; Department of Microbiology and Immunology, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Drobyski WR; Department of Medicine, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Saroz Y; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, 1142 Auckland, New Zealand., Grimsey N; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, 1142 Auckland, New Zealand., Honer M; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Fingerle J; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Gawrisch K; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, United States., Romero J; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223, Madrid, Spain., Hillard CJ; Department of Pharmacology and Clinical Pharmacology, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Varga ZV; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, United States.; HCEMM-SU Cardiometabolic Immunology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1085 Budapest, Hungary., van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, 2333 CC, Leiden, The Netherlands., Pacher P; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, United States., Gertsch J; Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland., McCormick PJ; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, England., Ullmer C; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Oddi S; Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.; European Center for Brain Research (CERC)/Santa Lucia Foundation, 00179 Rome, Italy., Maccarrone M; European Center for Brain Research (CERC)/Santa Lucia Foundation, 00179 Rome, Italy.; Department of Applied Clinical and Biotechnological Sciences, University of L'Aquila, 67100 L'Aquila, Italy., Veprintsev DB; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands B15 2TT, U.K., Nazaré M; Leibniz-Institut für Molekulare Pharmakologie FMP, Campus Berlin-Buch, 13125 Berlin, Germany., Grether U; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Carreira EM; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2020 Oct 07; Vol. 142 (40), pp. 16953-16964. Date of Electronic Publication: 2020 Sep 29.
Autor:
Westphal MV; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Hudson L; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Mason JW; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Pradeilles JA; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Zécri FJ; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Briner K; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, United States.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2020 Apr 29; Vol. 142 (17), pp. 7776-7782. Date of Electronic Publication: 2020 Apr 16.
Autor:
Westphal MV; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland., Sarott RC; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland., Zirwes EA; Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland., Osterwald A; Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland., Guba W; Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland., Ullmer C; Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland., Grether U; Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland., Carreira EM; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Jan 27; Vol. 26 (6), pp. 1380-1387. Date of Electronic Publication: 2020 Jan 21.
Autor:
Soethoudt M, Stolze SC, Westphal MV; Laboratorium für Organische Chemie , Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3 , Zürich 8093 , Switzerland., van Stralen L; Department of Rheumatology , Leiden University Medical Center , Albinusdreef 2 , Leiden 2333 ZA , The Netherlands., Martella A, van Rooden EJ, Guba W; Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , Basel 4070 , Switzerland., Varga ZV; Laboratory of Cardiovascular Physiology and Tissue Injury , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , 5625 Fishers Lane , Rockville , Maryland 20852 , United States., Deng H, van Kasteren SI, Grether U; Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , Basel 4070 , Switzerland., IJzerman AP, Pacher P; Laboratory of Cardiovascular Physiology and Tissue Injury , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , 5625 Fishers Lane , Rockville , Maryland 20852 , United States., Carreira EM; Laboratorium für Organische Chemie , Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3 , Zürich 8093 , Switzerland., Overkleeft HS, Ioan-Facsinay A; Department of Rheumatology , Leiden University Medical Center , Albinusdreef 2 , Leiden 2333 ZA , The Netherlands., Heitman LH, van der Stelt M
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2018 May 16; Vol. 140 (19), pp. 6067-6075. Date of Electronic Publication: 2018 Feb 16.
Autor:
Westphal MV; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Schafroth MA; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Sarott RC; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Imhof MA; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Bold CP; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Leippe P; Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians University Munich , Butenandtstraße 5-13, 81377 Munich, Germany., Dhopeshwarkar A; Department of Psychological and Brain Sciences and the Gill Center, Indiana University , Bloomington, Indiana 47405, United States., Grandner JM; Department of Biological Sciences and Department of Chemistry, Bridge Institute, University of Southern California , Los Angeles, California 90089, United States., Katritch V; Department of Biological Sciences and Department of Chemistry, Bridge Institute, University of Southern California , Los Angeles, California 90089, United States., Mackie K; Department of Psychological and Brain Sciences and the Gill Center, Indiana University , Bloomington, Indiana 47405, United States., Trauner D; Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians University Munich , Butenandtstraße 5-13, 81377 Munich, Germany.; Department of Chemistry, New York University , 100 Washington Square East, New York, New York 10003-6699, United States., Carreira EM; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Frank JA; Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians University Munich , Butenandtstraße 5-13, 81377 Munich, Germany.
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2017 Dec 20; Vol. 139 (50), pp. 18206-18212. Date of Electronic Publication: 2017 Dec 12.