Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Weston Sutherland"'
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:98-107
Contractility measurements using primary isolated cardiac myocytes (CM) have commonly been used in understanding the physiology and pharmacology of cellular mechanics. In the majority of studies, CM from healthy animals were used, and fewer studies w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df8d0e8fc2ccf686f6322e991bd4c7b
https://doi.org/10.1016/j.vascn.2018.06.001
https://doi.org/10.1016/j.vascn.2018.06.001
Autor:
Weston Sutherland, Max Escamilla, Jeanine Bussiere, Dina Andrews, Fang Xie, Aldo Coppi, Simon Authier, Kristen Holbrook, Loïs S. Miraucourt, Shane Barry, Brooke Rock
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 111:107017
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b978ef4112551a3e0f45a3fe2e7e538
https://doi.org/10.1016/j.vascn.2021.107017
https://doi.org/10.1016/j.vascn.2021.107017
Publikováno v:
Pharmacology Research & Perspectives
Omecamtiv mecarbil (OM) is a selective cardiac myosin activator (myotrope), currently in Phase 3 clinical investigation as a novel treatment for heart failure with reduced ejection fraction. OM increases cardiac contractility by enhancing interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4f18985d19f82154804067fb42e123
https://doi.org/10.1016/j.vascn.2021.107010
https://doi.org/10.1016/j.vascn.2021.107010
Autor:
Jonathan B. Houze, Andrea Boden, Ning Li, Dongming M. Liu, Xun Li, Jing Man Wong, Paul John Dransfield, Khanh Nguyen, Sridharan Rajamani, Gayathri Swaminath, Weston Sutherland, Yaping Sun, Ying Zhang, Vatee Pattaropong, Rhonda Chen, Vishnu Chintalgattu, Xiaochuan Ma, Murielle M. Véniant, Jim R. Turk, Ray W. Chui, Jinghong Wang, BaoXi Gao, Mark R. Fielden, Joyce Chi Yee Chan, Hugo M. Vargas, Kimberly M. Hoagland, Yinhong Chen, Yusheng Qu, Aarif Y. Khakoo, Shirley Mihardja, Qi Guo, Brandon Ason, Liaoyuan A. Hu, Ji Ma
Publikováno v:
JCI Insight
Heart failure (HF) remains a grievous illness with poor prognosis even with optimal care. The apelin receptor (APJ) counteracts the pressor effect of angiotensin II, attenuates ischemic injury, and has the potential to be a novel target to treat HF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3042c04a79fb6373e3d1699adde8eb0a
https://pubmed.ncbi.nlm.nih.gov/32208384
https://pubmed.ncbi.nlm.nih.gov/32208384
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106754
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f7ff84480821097908839e8a2683908
https://doi.org/10.1016/j.vascn.2020.106754
https://doi.org/10.1016/j.vascn.2020.106754
Autor:
Joel Baublits, Weston Sutherland, Hugo M. Vargas, Maximiliano Escamilla, Shane Barry, Ray W. Chui, Michael J. Engwall
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22411d2b13a58696159123277f55fe67
https://doi.org/10.1016/j.vascn.2019.05.046
https://doi.org/10.1016/j.vascn.2019.05.046
Autor:
Henry Schultz, Weston Sutherland, Anne C. Heatherington, Raheem Khaja, C. Glenn Begley, Steve Elliott, Juan Del Castillo, Patricia McElroy, Cynthia Hartley, Graham Molineux, Tom Graves
Publikováno v:
British Journal of Haematology. 122:623-636
Summary. Despite its frequency and impact on clinical outcomes, anaemia in cancer patients remains poorly understood and suboptimally treated. The definition of optimum treatment schedules with erythropoietic agents requires a suitable model of chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e35ff957f61e3d9e9a75b68afcf6ff
https://doi.org/10.1046/j.1365-2141.2003.04467.x
https://doi.org/10.1046/j.1365-2141.2003.04467.x
Autor:
Shane Barry, Ray W. Chui, BaoXi Gao, Jhun Viray, Sean Davis, Hugo M. Vargas, Yusheng Qu, Weston Sutherland, Max Escamilla
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:230
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a43752d51bd228e93653c8aaf3a4dedc
https://doi.org/10.1016/j.vascn.2017.09.203
https://doi.org/10.1016/j.vascn.2017.09.203
Autor:
Marco A. Coccia, Patricia McElroy, Graham Molineux, Weston Sutherland, Juan Del Castillo, John E. Tarpley, Jeanne Pistillo, Cynthia Hartley
Publikováno v:
Experimental Hematology. 29:59-67
Therapeutic use of recombinant human cytokines in humans can result in the generation of drug-specific antibodies. To predetermine the maximum potential effects of a granulocyte colony-stimulating factor (G-CSF) neutralizing auto-immunoglobulin G (au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c1488dfa4ab16d4c8dc787d3342e9b
https://doi.org/10.1016/s0301-472x(00)00614-7
https://doi.org/10.1016/s0301-472x(00)00614-7
Autor:
Patrick Kerzic, Pamela Lockbaum, Ian McNiece, Frederick A. Fletcher, Brent Kern, Bob Briddell, Graham Molineux, Cynthia Hartley, Sheila Gardner, Weston Sutherland, Mary Ann Miller-Messana, Elliot Korach, Greg Stoney, Art Cohen, Patricia McElroy, Tom Ulich, Olaf B Kinstler, Gisela Schwab, Thomas Hunt
Publikováno v:
Experimental Hematology. 27:1724-1734
Granulocyte colony-stimulating factor (G-CSF) has proven effective in the prophylaxis of chemotherapy-induced neutropenia and as a mobilizer of peripheral blood progenitor cells. The longevity of G-CSF action is limited by its removal from the body b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea119bf2b2061e9c5c181e345bfda97f
https://doi.org/10.1016/s0301-472x(99)00112-5
https://doi.org/10.1016/s0301-472x(99)00112-5