Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Weston R. Gould"'
Autor:
T R Johnson, Kathy Welch, Sangita M. Baxi, Thomas B. McClanahan, Liguo Chi, Weston R. Gould, Robert J. Leadley, Kamlai Saiya-Cork
Publikováno v:
Journal of Thrombosis and Haemostasis. 4:834-841
Summary. Background: Many compounds currently in development for treatment of thrombotic disorders demonstrate high specificity for single targets of blood coagulation such as factor Xa (FXa) or thrombin. Aim: The aim of this study is to determine if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6968e17661032b0acb202d331d0dd21
https://doi.org/10.1111/j.1538-7836.2006.01830.x
https://doi.org/10.1111/j.1538-7836.2006.01830.x
Autor:
Yun-Wen Peng, J. T. Peterson, Lisa A. Perrin, Richard L Schroeder, Robert J. Leadley, Weston R. Gould, Sangita M. Baxi
Publikováno v:
Journal of Thrombosis and Haemostasis. 3:733-741
Summary. Gas6 (encoded by growth arrest-specific gene 6) is a vitamin-K dependent protein highly homologous to coagulation protein S that is secreted from platelet α-granules and has recently been demonstrated to participate in platelet thrombus for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7766ec7e2943947aa610b1a800e9e736
https://doi.org/10.1111/j.1538-7836.2005.01186.x
https://doi.org/10.1111/j.1538-7836.2005.01186.x
Publikováno v:
Journal of Biological Chemistry. 279:2383-2393
Platelet- and plasma-derived factor Va (FVa) serve essential cofactor roles in prothrombinase-catalyzed thrombin generation. Platelet-derived FV/Va, purified from Triton X-100 platelet lysates was composed of a mixture of polypeptides ranging from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7232c456d9dbb2d9ba0aa3b8c1206e4
https://doi.org/10.1074/jbc.m308600200
https://doi.org/10.1074/jbc.m308600200
Autor:
Jennifer Marie Thorn, Lakshmi Narasimhan, Weston R. Gould, Robert J. Leadley, Melissa S. Harris, Erli Zhang, Edward Cladera
Publikováno v:
Biochemistry. 44(26)
The enzyme complex prothrombinase plays a pivotal role in fibrin clot development through the production of thrombin, making this enzyme complex an attractive target for therapeutic regulation. This study both functionally and structurally characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e67c011d921cac394eaaafacd0f8f4
https://pubmed.ncbi.nlm.nih.gov/15981994
https://pubmed.ncbi.nlm.nih.gov/15981994
Publikováno v:
The Journal of biological chemistry. 279(4)
Platelet- and plasma-derived factor Va (FVa) serve essential cofactor roles in prothrombinase-catalyzed thrombin generation. Platelet-derived FV/Va, purified from Triton X-100 platelet lysates was composed of a mixture of polypeptides ranging from ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73384306276d63129603c0b360e58ccf
https://pubmed.ncbi.nlm.nih.gov/14594814
https://pubmed.ncbi.nlm.nih.gov/14594814
Autor:
Weston R. Gould, Robert J. Leadley
Publikováno v:
Current pharmaceutical design. 9(28)
Coronary heart disease (CHD) is the leading cause of mortality and morbidity in the United States. Currently, there are approximately 12 million Americans with CHD, which is most frequently caused by atherosclerosis. The thrombotic complications of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239a3d284469e35ad1345b1e7b2a2578
https://pubmed.ncbi.nlm.nih.gov/14529395
https://pubmed.ncbi.nlm.nih.gov/14529395
Autor:
Theodore O. Johnson, Weston R. Gould, Kathy Welch, Thomas B. McClanahan, Liguo Chi, Sangita M. Baxi, Tawny K. Dahring, Robert J. Leadley, Gary Hicks
Publikováno v:
Blood. 106:1866-1866
Several compounds currently in development for the treatment of thrombotic disorders demonstrate high levels of specificity for single targets of the blood coagulation cascade such as factor Xa and thrombin. However, development of a single molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237c5a04c7ea1d5f7af3dd2ed7ba0268
https://doi.org/10.1182/blood.v106.11.1866.1866
https://doi.org/10.1182/blood.v106.11.1866.1866
Publikováno v:
Blood. 106:1877-1877
Inhibition of either coagulation factor Xa (FXa) or thrombin (FIIa) alters ex vivo biomarkers of coagulation and decreases thrombus size in animal models of experimental thrombosis. The objective of this study was to determine if combining FXa and FI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::942b6f4fce52b53874bf954e9822afaf
https://doi.org/10.1182/blood.v106.11.1877.1877
https://doi.org/10.1182/blood.v106.11.1877.1877
Publikováno v:
Blood. 104:630-630
At the site of vascular injury, platelet activation is paramount in supporting formation of a platelet plug and generating a functional surface for the protein elements of coagulation. Recently, we demonstrated that the receptors for the α-granule c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8823b9d10f4719160e5832760102651f
https://doi.org/10.1182/blood.v104.11.630.630
https://doi.org/10.1182/blood.v104.11.630.630