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pro vyhledávání: '"Weston Neil Philip"'
Autor:
David R. Bill, Ruggeri Sally G, Weston Neil Philip, Lulin Wei, Michael J. Castaldi, Tim L. Houck, Dennis E. Bourassa, David H. Brown Ripin
Publikováno v:
Organic Process Research & Development. 7:1043-1047
A scalable route to 5-(2-carboxy-pyridin-2-yloxy)-benz[1,2,5]oxadiazole (3) is demonstrated. The synthesis was designed to minimize potential safety issues with a previously practiced route and, in particular, to avoid the handling of 5-hydroxybenzof
Autor:
Steven J. Brenek, John J. Teixeira, Robert A. Singer, Shane A. Eisenbeis, Weston Neil Philip, Brian C. Vanderplas, John A. Ragan, David J. am Ende, Derek L. Tickner
Publikováno v:
Organic Process Research & Development. 7:155-160
Several routes to bisulfite adduct 2 were explored, the most efficient of which involved vinyl Grignard addition to 2-indanone followed by ozonolysis and workup with aqueous NaHSO3 to effect reduction and bisulfite formation in a single pot. The safe