Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Weston J. Smith"'
Autor:
Susan D. Richardson, Sarah H. Warren, Hannah K. Liberatore, David M. DeMarini, Weston J Smith
Publikováno v:
Environ Mol Mutagen
Drinking water disinfection by-products (DBPs), including the ubiquitous trihalomethanes (THMs), are formed during the treatment of water with disinfectants (e.g., chlorine, chloramines) to produce and distribute potable water. Brominated THMs (Br-TH
Autor:
Robert I. Scheinman, Dmitri Simberg, Weston J. Smith, Laren A. Lofchy, Vivian P. Vu, Hanmant Gaikwad, Geoffrey Gifford, Nirmal K. Banda, Joseline Ramos Ramirez
Publikováno v:
Mol Pharm
Diseases of the joints affect over 10% of the world’s population, resulting in significant morbidity. There is an unmet need in strategies for specific delivery of therapeutics to the joints. Collagen type II is synthesized by chondrocytes and is m
Autor:
David W. A. Bourne, Guankui Wang, Vivian P. Vu, Weston J. Smith, Hanmant Gaikwad, Dmitri Simberg, Ernest Groman
Publikováno v:
ACS Nano. 12:12523-12532
Long blood half-life is one of the advantages of antibodies over small molecule drugs. At the same time, prolonged half-life is a problem for imaging applications or in the case of antibody-induced toxicities. There is a substantial need for antidote
Autor:
Weston J. Smith, Vivian P. Vu, James I. Griffin, Lizanne G. Nilewski, Jessica F. Jones, Huy Tran, Dmitri Simberg, Nathan C. Gianneschi
Publikováno v:
Biomaterials. 161:57-68
Decoration of cell membranes with biomolecules, targeting ligands and imaging agents is an emerging strategy to improve functionality of cell-based therapies. Compared to covalent (e.g., click) chemistry or genetic expression on the cell surface, lip
Autor:
Zachary L. Rodgers, Song Ding, Weston J. Smith, Robert M. Hughes, Nathan P. Oien, David S. Lawrence, Christina M. Marvin
Publikováno v:
Angewandte Chemie International Edition. 55:16080-16083
A strategy for the light-activated release of bioactive compounds (BODIPY, colchicine, paclitaxel, and methotrexate) from membrane-enclosed depots is described. We have found that membrane-permeable bioagents can be rendered membrane impermeable by c
Autor:
Hanmant Gaikwad, Guankui Wang, Weston J. Smith, Dmitri Simberg, Angelo D'Alessandro, Enkhtsetseg Purev, Keisha Alexander, Wei Zhang
Publikováno v:
Bioconjug Chem
Cell-based therapeutics are one of the most promising and exciting breakthroughs in modern medicine. Modification of the cell surface with ligands, biologics, drugs, and nanoparticles can further enhance the functionality. Previously, we described th
Autor:
Dmitri Simberg, Guankui Wang, Radu Moldovan, Vivian P. Vu, Robert I. Scheinman, Weston J. Smith, Seyed Moein Moghimi, James I. Griffin, Dominik Stitch
Publikováno v:
ACS nano. 11(11)
Accumulation of intravenously injected cytotoxic liposomes in the skin induces serious toxicity. We used single time point and longitudinal intravital microscopy to understand skin accumulation dynamics of non-PEGylated and PEGylated liposomes after
Autor:
Robert M. Hughes, Christina M. Marvin, Zachary L. Rodgers, Song Ding, Nathan P. Oien, Weston J. Smith, David S. Lawrence
A strategy for the light-activated release of bioactive compounds (BODIPY, colchicine, paclitaxel, and methotrexate) from membrane-enclosed depots is described. We have found that membrane-permeable bioagents can be rendered membrane impermeable by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbbb970f02a45a40549ef06e93d4343
Autor:
Robert M. Hughes, Rebecca M. Pollet, David S. Lawrence, Weston J. Smith, Kelsey N. Lamb, David J. Freeman
An optogenetic Bax has been designed that facilitates light-induced apoptosis. We demonstrate that mitochondrial recruitment of a genetically encoded light-responsive Bax results in the release of mitochondrial proteins, downstream caspase-3 cleavage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f17e43c125191e6e8afcb5e76d400c
Autor:
Christina M. Marvin, Nathan P. Oien, Weston J. Smith, Zachary L. Rodgers, David S. Lawrence, Junghyun Lee, Robert M. Hughes
Light-activatable drugs offer the promise of controlled release with exquisite temporal and spatial resolution. However, light-sensitive prodrugs are typically converted to their active forms using short-wavelength irradiation, which displays poor ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5caf7c5933d6ac3080b8aa21c9509109