Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Weston Helen Elisabeth"'
Autor:
Alan D. Borthwick, Marie Charbaut, Robert J. Young, Máire A. Convery, Ivan Leo Pinto, Andrew M. Mason, Weston Helen Elisabeth, Matthew Campbell, David W. Brown, Anthony J. Pateman, Henry Anderson Kelly, Derek Pollard, Shah Gita Punjabhai, John R. Toomey, N. Paul King, Stefan Senger, Eric Hortense, Ping Zhou, Hawa Diallo, Nigel S. Watson, Wendy R. Irving, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Chuen Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:28-33
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activitie
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs
Autor:
N. Paul King, Stefan Senger, Matthew Campbell, Henry Anderson Kelly, Máire A. Convery, David W. Brown, Shah Gita Punjabhai, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Marie Charbaut, Alan D. Borthwick, Ivan Leo Pinto, Weston Helen Elisabeth, John R. Toomey, Chuen Chan, Chun-wa Chung, Robert J. Young, Nigel S. Watson, Derek Pollard, Andrew M. Mason, Anthony J. Pateman
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(1)
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles
Autor:
Robert J. Young, Alan D. Borthwick, Nigel S. Watson, Weston Helen Elisabeth, Chun-wa Chung, J. Nicole Hamblin, Chuen Chan, Anthony J. Pateman, Savvas Kleanthous, Laiq Chaudry, Shah Gita Punjabhai, David W. Brown, Matthew Campbell, Champa Patel, Máire A. Convery, Stefan Senger, Lisa Johnstone, Angela Patikis, Cynthia L. Burns-Kurtis, Henry Anderson Kelly, Caroline Whitworth, Ping Zhou, John R. Toomey
Publikováno v:
Journal of medicinal chemistry. 50(7)
Factor Xa inhibitory activities for a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides with different P1 groups are described. These data provide insight into binding interactions within the S1 primary
Autor:
Matthew Campbell, Ping Zhou, Robert J. Young, Weston Helen Elisabeth, Savvas Kleanthous, David W. Brown, Champa Patel, Satish Dayal, Shah Gita Punjabhai, Alan D. Borthwick, N. Paul King, Cynthia L. Burns-Kurtis, Stefan Senger, Hawa Diallo, Máire A. Convery, Nigel S. Watson, Paul W. Smith, Henry Anderson Kelly, Miriam Crowe, Chuen Chan, Anthony J. Pateman, Jackie E. Mordaunt, Andrew M. Mason
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(23)
Structure-based drug design was exploited in the synthesis of 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group with acyclic tertiary amide termini. Optimized hydrophobic cont
Autor:
Vipulkumar Kantibhai Patel, Máire A. Convery, J. Nicole Hamblin, Andrew M. Mason, Andrew R. Leach, N. Paul King, Shah Gita Punjabhai, Stefan Senger, Laiq Chaudry, Caroline Whitworth, Rebecca Fenwick, Robert J. Young, Matthew Campbell, Cynthia L. Kurtis, Claudine Haslam, Henry Anderson Kelly, Champa Patel, Weston Helen Elisabeth, Charlotte Jane Mitchell, David W. Brown, Gary R. Manchee, Nigel S. Watson, Chuen Chan
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(14)
A series of novel, non-basic 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group, was designed and synthesised. Within this series, the N-2-(morpholin-4-yl)-2-oxoethyl derivativ