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Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening.

Autor: Disch JS; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Duffy JM; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Lee ECY; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Gikunju D; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Chan B; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Levin B; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Monteiro MI; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Talcott SA; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Lau AC; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Zhou F; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Kozhushnyan A; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Westlund NE; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Mullins PB; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Yu Y; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., von Rechenberg M; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Zhang J; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Arnautova YA; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Liu Y; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Zhang Y; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., McRiner AJ; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Keefe AD; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Kohlmann A; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Clark MA; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Cuozzo JW; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Huguet C; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Arora S; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 5049-5066. Date of Electronic Publication: 2021 Apr 12.