Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Westley Tear"'
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783031186288
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b5da7c3455a579b86b7e41645bac545
https://doi.org/10.1007/7355_2022_150
https://doi.org/10.1007/7355_2022_150
Autor:
Miguel Navarro, Quillon J. Simpson, Travis J. DeLano, Maria Santos Martinez-Martinez, Raquel García-Hernández, Rosario Diaz-Gonzalez, Westley Tear, Guiomar Pérez-Moreno, William G. Devine, Lori Ferrins, Dolores González-Pacanowska, Luis M. Ruiz-Pérez, Melanie G. Fritsche, Katherine M. Schneider, Michael P. Pollastri, Francisco Gamarro, John K. Fisher, Cristina Bosch-Navarrete, Pilar Manzano-Chinchon, Vivian Hilborne, Dana M. Klug, Raeann M. Dalton, Gloria Ceballos-Pérez, Eftychia M. Mavrogiannaki, Melissa J. Buskes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem
Human African trypanosomiasis is a neglected tropical disease (NTD) that is fatal if left untreated. Although approximately 13 million people live in moderate- to high-risk areas for infection, current treatments are plagued by problems with safety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c419df9071d8f28b3bdefbdbcc538de7
http://hdl.handle.net/10261/246477
http://hdl.handle.net/10261/246477
Autor:
Raquel García-Hernández, Domingo I. Rojas-Barros, Michael P. Pollastri, Conor R. Caffrey, Gloria Ceballos-Pérez, Pilar Manzano, Luis M. Ruiz-Pérez, Maria Santos Martinez-Martinez, Lori Ferrins, Carlos Cordon-Obras, Westley Tear, Seema Bag, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Francisco Gamarro, Dolores Gonzalez Pacanowska, Miguel Navarro
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
From a high-throughput screen of 42 444 knownhuman kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold wasidentified to begin optimization for the treatment of human Africantrypanosomiasis. Previously reported data for analogous com-pounds again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155e0c5832d1468a3b1529e2bdbaaaa5
http://hdl.handle.net/10261/213997
http://hdl.handle.net/10261/213997
Autor:
Paola C. Zucchi, James B. Aggen, Bilyana N. Koleva, Andrew Spaulding, Harold D. Cooper, Pornachandran Mahalingam, Dillon Cleary, Elizabeth B. Hirsch, Westley Tear, Penny J. Beuning, Khuloud Takrouri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5310-5321
Previously we reported the results from an effort to improve Gram-negative antibacterial activity in the oxazolidinone class of antibiotics via a systematic medicinal chemistry campaign focused entirely on C-ring modifications. In that series we set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236efc44ee9bb5175a92e6c39fcfcf65
https://doi.org/10.1016/j.bmcl.2017.10.018
https://doi.org/10.1016/j.bmcl.2017.10.018
Autor:
James B. Aggen, Harold D. Cooper, Elizabeth B. Hirsch, Bilyana N. Koleva, Paola C. Zucchi, Khuloud Takrouri, Dillon Cleary, Penny J. Beuning, Westley Tear, Andrew Spaulding
Publikováno v:
ACS Infectious Diseases. 2:405-426
Novel antibacterials with activity against the Gram-negative bacteria associated with nosocomial infections, including Escherichia coli and other Enterobacteriaceae, are urgently needed due to the increasing prevalence of multidrug-resistant strains.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917f67d94d1e189f8c0b65385f3d5da9
https://doi.org/10.1021/acsinfecdis.6b00003
https://doi.org/10.1021/acsinfecdis.6b00003
Autor:
Miguel Navarro, Ranae M. Ranade, Michael P. Pollastri, Gloria Ceballos-Pérez, William G. Devine, Wim G. J. Hol, Westley Tear, Frederick S. Buckner, Takashi Satoh, Domingo Rojas, Rosario Diaz-Gonzalez, Ximena Barros-Álvarez
Human African trypanosomiasis is a neglected tropical disease that is lethal if left untreated. Existing therapeutics have limited efficacy and severe associated toxicities. 2-(2-(((3-((1H-Benzo[d]imidazol-2-yl)amino)propyl)amino)methyl)-4,6-dichloro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e0777b3fa6e7e9b3041a5f3e88951d
https://europepmc.org/articles/PMC5346068/
https://europepmc.org/articles/PMC5346068/