Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients.

Autor: Bethge WA; Department of Hematology, Oncology, Clinical Immunology and Rheumatology, Center for Internal Medicine, University Hospital Tuebingen, Tuebingen, Germany. wolfgang.bethge@med.uni-tuebingen.de., Eyrich M; University Children's Hospital Wuerzburg, Wuerzburg, Germany., Mielke S; Karolinska Institutet and University Hospital, Department of Laboratory Medicine and Department of Medicine Huddinge, CAST, Karolinska Comprehensive Cancer Center, Stockholm, Sweden.; Department of Internal Medicine II, Wuerzburg University Medical Center, Wuerzburg, Germany., Meisel R; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany., Niederwieser D; University Leipzig, Leipzig, Germany., Schlegel PG; University Children's Hospital Wuerzburg, Wuerzburg, Germany., Schulz A; Department of Pediatrics, University Medical Center Ulm, Ulm, Germany., Greil J; University Children's Hospital Heidelberg, Heidelberg, Germany., Bunjes D; Department of Internal Medicine III, University of Ulm, Ulm, Germany., Brecht A; KMT-Abteilung, Helios Dr. Horst Schmidt Kliniken, Wiesbaden, Germany., Kuball J; Department of Haematology and Center for Translational Immunology, University Medical Centre, Utrecht, The Netherlands., Schumm M; CureVac RE GmbH, Tuebingen, Germany.; Department of Hematology/Oncology, University Children's Hospital Tuebingen, Tuebingen, Germany., Vucinic V; University Leipzig, Leipzig, Germany., Wiesneth M; Institute of Transfusion Medicine, University of Ulm, Ulm, Germany., Bonig H; Institute for Transfusion Medicine and Immunohematology, and German Red Cross Blood Service BaWüHe, Goethe University, Frankfurt, Germany., Westinga K; Cell Therapy Facility, University Medical Center Utrecht, Utrecht, The Netherlands., Biedermann S; Miltenyi Biotec, Bergisch Gladbach, Germany., Holtkamp S; Miltenyi Biomedicine, Bergisch Gladbach, Germany., Karitzky S; Miltenyi Biomedicine, Bergisch Gladbach, Germany., Malchow M; Miltenyi Biomedicine, Bergisch Gladbach, Germany., Siewert C; Miltenyi Biotec, Bergisch Gladbach, Germany., Handgretinger R; Department of Hematology/Oncology, University Children's Hospital Tuebingen, Tuebingen, Germany., Lang P; Department of Hematology/Oncology, University Children's Hospital Tuebingen, Tuebingen, Germany. peter.lang@med.uni-tuebingen.de.

Publikováno v: Bone marrow transplantation [Bone Marrow Transplant] 2022 Mar; Vol. 57 (3), pp. 423-430. Date of Electronic Publication: 2021 Dec 24.

Allogeneic Stem Cell Transplantation Platforms With Ex Vivo and In Vivo Immune Manipulations: Count and Adjust.

Autor: de Witte M; Department of Hematology, University Medical Center Utrecht, The Netherlands., Daenen LGM; Department of Hematology, University Medical Center Utrecht, The Netherlands., van der Wagen L; Department of Hematology, University Medical Center Utrecht, The Netherlands., van Rhenen A; Department of Hematology, University Medical Center Utrecht, The Netherlands., Raymakers R; Department of Hematology, University Medical Center Utrecht, The Netherlands., Westinga K; Cell Therapy Facility, University Medical Center Utrecht, The Netherlands., Kuball J; Department of Hematology, University Medical Center Utrecht, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, The Netherlands.

Publikováno v: HemaSphere [Hemasphere] 2021 Jun 01; Vol. 5 (6), pp. e580. Date of Electronic Publication: 2021 Jun 01 (Print Publication: 2021).

Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile.

Autor: van der Wagen LE; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Miranda-Bedate A; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Janssen A; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Fernando F; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Appukudige N; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Dooremalen S; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Westinga K; Cell Therapy Facility, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Admiraal R; Pediatric Blood and Marrow Transplant Program Prinses Maxima Centre for Pediatric Oncology, Utrecht, the Netherlands., Lorenowicz MJ; Center for Molecular Medicine and Regenerative Medicine Center UMC Utrecht, Utrecht University, Utrecht, the Netherlands., Huls G; Department of Hematology, UMC Groningen, Groningen, the Netherlands., Janssen JJWM; Department of Hematology, Amsterdam University Medical Centers, loc. VUmc Amsterdam, Amsterdam, the Netherlands., Broers AEC; Department of Hematology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., van der Velden WJFM; Department of Hematology, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands., van Marwijk Kooy R; Department of Internal Medicine, Isala klinieken Zwolle, Zwolle, the Netherlands., Hazenberg MD; Department of Hematology, Academic Medical Center Amsterdam, Amsterdam, the Netherlands., de Haar C; Cell Therapy Facility, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Lindemans C; Department of Hematology, Princess Maxima Centrum, Utrecht, the Netherlands., Jan Boelens J; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Pediatrics, Stem Cell Transplant and Cellular Therapies Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kuball J; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. J.H.E.Kuball@umcutrecht.nl.; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. J.H.E.Kuball@umcutrecht.nl.

Publikováno v: Bone marrow transplantation [Bone Marrow Transplant] 2020 Nov; Vol. 55 (11), pp. 2188-2192. Date of Electronic Publication: 2020 Apr 28.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Phase I/II open-label trial of intravenous allogeneic mesenchymal stromal cell therapy in adults with recessive dystrophic epidermolysis bullosa.

Autor: Rashidghamat E; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK., Kadiyirire T; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK., Ayis S; School of Population Health and Environmental Sciences, King's College London, London, UK., Petrof G; Department of Dermatology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Liu L; The Robin Eady National Diagnostic Epidermolysis Bullosa Laboratory, Viapath, Guy's Hospital, London, UK., Pullabhatla V; UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK., Ainali C; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK; Dignosis Ltd, London, UK., Guy A; The Robin Eady National Diagnostic Epidermolysis Bullosa Laboratory, Viapath, Guy's Hospital, London, UK., Aristodemou S; The Robin Eady National Diagnostic Epidermolysis Bullosa Laboratory, Viapath, Guy's Hospital, London, UK., McMillan JR; The Robin Eady National Diagnostic Epidermolysis Bullosa Laboratory, Viapath, Guy's Hospital, London, UK., Ozoemena L; The Robin Eady National Diagnostic Epidermolysis Bullosa Laboratory, Viapath, Guy's Hospital, London, UK., Mee J; Immunodermatology Laboratory, Viapath, St Thomas' Hospital, London, UK., Pramanik R; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK., Saxena A; UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK., Nuamah R; UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK., de Rinaldis E; I&I Precision Immunology, Sanofi, Cambridge, Massachusetts., Serrano S; Clinical Trial Management Research Platform, NIHR Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK., Maurin C; Clinical Trial Management Research Platform, NIHR Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK., Martinez-Queipo M; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK., Lwin SM; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK., Ilic D; Stem Cell Laboratories, Guy's Assisted Conception Unit, Department of Women & Children's Health, Faculty of Life Sciences & Medicine, King's College London, London, UK., Martinez A; Department of Dermatology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Dazzi F; Department of Haematological Medicine, The Rayne Institute, King's College London, London, UK., Slaper-Cortenbach I; Cell Therapy Facility, Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands., Westinga K; Cell Therapy Facility, Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands., Zeddies S; Cell Therapy Facility, Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands., van den Broek M; Cell Therapy Facility, Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands., Onoufriadis A; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK., Mellerio JE; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK., McGrath JA; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK. Electronic address: john.mcgrath@kcl.ac.uk.

Publikováno v: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2020 Aug; Vol. 83 (2), pp. 447-454. Date of Electronic Publication: 2019 Nov 28.