Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Westin Eriksson A"'
Autor:
Hans Ericsson, Igor L. Shamovsky, Carl Whatling, Malin Lemurell, Marianne Swanson, Eva-Lotte Lindstedt, Johan Broddefalk, Mats Någård, Anita Dellsén, Johan Ulander, Carl Amilon, Kenneth Granberg, Annika Westin Eriksson, Daniel Pettersen, Alleyn T. Plowright, Monica Sundqvist, Hans Emtenäs, Martin A. Hayes
Publikováno v:
Journal of Medicinal Chemistry. 62:4312-4324
5-Lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway activity and reduce the production of proinflammatory and vasoactive leukotrienes. As such, they are hypothesized to have therapeutic benefit for the treatment of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f5cbb07e77468dbbb61f1fcb001052
https://doi.org/10.1021/acs.jmedchem.8b02004
https://doi.org/10.1021/acs.jmedchem.8b02004
Autor:
Christian Tyrchan, Anna-Pia Palmgren, Hui-Fang Amy Chang, Yunhua Chen, Victoria Ullah, Karin Björhall, Annika Westin Eriksson, Rebecca Fransson, Mickael Mogemark, Tiiu Wennberg, Shuchun Zhao, Bold Peter, Linda Fredlund, Matthew Thomas, Eva Lamm Bergström, Nils Pemberton, Ulf Börjesson, Reed W. Smith, Mikael Brűlls, Johan Carlsson, Britt-Marie Fihn, Linda Öster, Mio Rodrigo Blomqvist, Hongbin Ge, Antonios Nikitidis, Wenzhen Yang, Anders Eriksson, Haijuan Huang, Sarah Lever, Perry Matthew, Kostas Karabelas, Helena Lindmark, Jens Petersen
Publikováno v:
Journal of medicinal chemistry. 64(12)
Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure-activity relationships that led to the discovery of highly potent dual PI3Kγδ inhibitors. We explored changes in two positions of the molecules, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1afe7cc480e1edf37ab207774eb9ff
https://pubmed.ncbi.nlm.nih.gov/34080862
https://pubmed.ncbi.nlm.nih.gov/34080862
Autor:
Annika Westin Eriksson, Matthew Thomas, Mickael Mogemark, Perry Matthew, Raolat M Abdulai, Barbara Valastro, Jens Petersen
Publikováno v:
Journal of Medicinal Chemistry. 62:4783-4814
Phosphoinositol 3-kinases (PI3Ks) γ and δ are key enzymes in hematopoietic cells and have been seen as high-value targets for the treatment of diseases with inflammatory and immunomodulatory components since their discovery and the identification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd2f7166f27f0b1f2779441002da1f7
https://doi.org/10.1021/acs.jmedchem.8b01298
https://doi.org/10.1021/acs.jmedchem.8b01298
Autor:
Christian Löfberg, Marianne Swanson, ZhongQing Yuan, Johan Broddefalk, Annika Westin Eriksson, Susanne Winiwarter, Martin A. Hayes, Gabrielle Saarinen, Johan Meuller, Carl Whatling, Johan Ulander, Hans Emtenäs, Johan Cassel, Monica Sundqvist, Malin Lemurell, Luna Prieto Garcia, Staffan Karlsson
Publikováno v:
Journal of medicinal chemistry. 62(9)
5-Lipoxygenase (5-LO)-activating protein (FLAP) inhibitors have proven to attenuate 5-LO pathway activity and leukotriene production in human clinical trials. However, previous clinical candidates have been discontinued and the link between FLAP inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff40a6805c4be041ac624c15aa826045
https://pubmed.ncbi.nlm.nih.gov/30929436
https://pubmed.ncbi.nlm.nih.gov/30929436
Autor:
Nils Pemberton, Cristina Gardelli, Jens Petersen, Neil S. Holden, Helena Lindmark, Pavol Zlatoidsky, Sandra Rodrigo Blomqvist, Annika Westin Eriksson, Rhona J. Cox, Linda Öster, Christian Tyrchan, Susanne Arlbrandt, Sarah Lever, Perry Matthew, Bold Peter, Mickael Mogemark, Matthew F. Thomas, A. Monica Norberg, Kostas Karabelas, Johan Karlsson, Xueshan Li
Publikováno v:
'Journal of Medicinal Chemistry ', vol: 61, pages: 5435-5441 (2018)
In this paper, we describe the discovery and optimization of a new chemotype of isoform selective PI3Kγ inhibitors. Starting from an HTS hit, potency and physicochemical properties could be improved to give compounds such as 15, which is a potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522cd582a4e8dd33b4cac2f260c043ff
https://pubmed.ncbi.nlm.nih.gov/29852070
https://pubmed.ncbi.nlm.nih.gov/29852070
Autor:
Perry, Matthew W. D., Björhall, Karin, Bold, Peter, Brűlls, Mikael, Börjesson, Ulf, Carlsson, Johan, Chang, Hui-Fang Amy, Chen, Yunhua, Eriksson, Anders, Fihn, Britt-Marie, Fransson, Rebecca, Fredlund, Linda, Ge, Hongbin, Huang, Haijuan, Karabelas, Kostas, Lamm Bergström, Eva, Lever, Sarah, Lindmark, Helena, Mogemark, Mickael, Nikitidis, Antonios, Palmgren, Anna-Pia, Pemberton, Nils, Petersen, Jens, Rodrigo Blomqvist, Mio, Smith, Reed W., Thomas, Matthew J., Ullah, Victoria, Tyrchan, Christian, Wennberg, Tiiu, Westin Eriksson, Annika, Yang, Wenzhen, Zhao, Shuchun, Öster, Linda
Publikováno v:
Journal of Medicinal Chemistry; June 2021, Vol. 64 Issue: 12 p8053-8075, 23p
Autor:
Perry, Matthew W. D., Abdulai, Raolat, Mogemark, Mickael, Petersen, Jens, Thomas, Matthew J., Valastro, Barbara, Westin Eriksson, Annika
Publikováno v:
Journal of Medicinal Chemistry; 5/23/2019, Vol. 62 Issue 10, p4783-4814, 32p
Autor:
Lemurell, Malin, Ulander, Johan, Emtenäs, Hans, Winiwarter, Susanne, Broddefalk, Johan, Swanson, Marianne, Hayes, Martin A., Prieto Garcia, Luna, Westin Eriksson, Annika, Meuller, Johan, Cassel, Johan, Saarinen, Gabrielle, Yuan, Zhong-Qing, Löfberg, Christian, Karlsson, Staffan, Sundqvist, Monica, Whatling, Carl
Publikováno v:
Journal of Medicinal Chemistry; 5/9/2019, Vol. 62 Issue 9, p4325-4349, 25p
Autor:
Pettersen, Daniel, Broddefalk, Johan, Emtenäs, Hans, Hayes, Martin A., Lemurell, Malin, Swanson, Marianne, Ulander, Johan, Whatling, Carl, Amilon, Carl, Ericsson, Hans, Westin Eriksson, Annika, Granberg, Kenneth, Plowright, Alleyn T., Shamovsky, Igor, Dellsèn, Anita, Sundqvist, Monica, Någård, Mats, Lindstedt, Eva-Lotte
Publikováno v:
Journal of Medicinal Chemistry; 5/9/2019, Vol. 62 Issue 9, p4312-4324, 13p
Autor:
Roland Stocker, Paul K. Witting, Anne-Margret Östlund-Lindqvist, Knut Pettersson, Annika Westin Eriksson, Christer Westerlund
Publikováno v:
Scopus-Elsevier
Antioxidants can inhibit atherosclerosis in animals, though it is not clear whether this is due to the inhibition of aortic lipoprotein lipid (per)oxidation. Coantioxidants inhibit radical-induced, tocopherol-mediated peroxidation of lipids in lipopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9240972c9e5ba1a2b999316ec4004bea
https://doi.org/10.1096/fasebj.13.6.667
https://doi.org/10.1096/fasebj.13.6.667