Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Westhoff, MA"'
Autor:
Tosin, D, Schlotter, D, Dwucet, A, Hlavac, M, Westhoff, MA, Siegelin, MD, Wirtz, CR, Karpel-Massler, G
Publikováno v:
73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCV175 /20220525/
Objective: A cellular homeostasis that is shifted away from apoptosis and a reprogramming of the lipid metabolism are both, features that are frequently encountered in glioblastoma. This study aimed at investigating whether a combined reprogramming o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08049fd5fc81bbd18280ce6a86ac695
Autor:
Spilz, A, Dwucet, A, Seyfried, F, Peraud, A, Prabhu, VV, Allen, JE, Westhoff, MA, Siegelin, MD, Wirtz, CR, Karpel-Massler, G
Publikováno v:
73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCV147 /20220525/
Objective: Medulloblastoma represents one of the most common brain tumors in children. We previously showed that the impipridone ONC201/TIC10 has a strong anti-neoplastic activity against medulloblastoma cells. In this study, we performed preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4212302985fb87ab9203a353acb1a984
Autor:
Cao, Q, Dwucet, A, Kast, R, Hlavac, M, Westhoff, MA, Siegelin, MD, Wirtz, CR, Halatsch, ME, Karpel-Massler, G
Publikováno v:
73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCP159 /20220525/
Objective: Drug repurposing is a promising strategy to accelerate the clinical use of therapeutics with anti-neoplastic activity. In this study, we examined whether Tumor Treating Fields (TTFields) enhance the biological effects of the repurposed CUS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99775228ac8597f7d0066165da7d6c70
Autor:
Halatsch, ME, Kast, R, Karpel-Massler, G, Mayer, B, Zolk, O, Schmitz, B, Scheuerle, A, Maier, L, Bullinger, L, Mayer-Steinacker, R, Schmidt, C, Zeiler, K, Elshaer, Z, Panther, P, Schmelzle, B, Hallmen, A, Dwucet, A, Siegelin, MD, Westhoff, MA, Beckers, K, Bouche, G, Heiland, T
Publikováno v:
72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; 20210606-20210609; sine loco [digital]; DOCP035 /20210604/
Objective: In an attempt to address the variety and ever-shifting array of growth-promoting pathways glioblastomas (GB) use to thrive and circumvent our treatment efforts, we developed a nine repurposed drug regimen, CUSP9v3, designed to be given wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e29081ae505117a5e370a034a174f3
Autor:
Anthonymuthu, J, Golla, C, Dwucet, A, Pruss, M, Hlavac, M, Kast, RE, Wirtz, CR, Halatsch, ME, Siegelin, MD, Westhoff, MA, Karpel-Massler, G
Publikováno v:
71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCV082 /20200626/
Objective: Vacquinol represents an experimental anti-malaria drug which has been previously described to provide anti-glioma activity.The purpose of this study was to examine whether treatment with vacquinol would enhance the pro-apoptotic reprogramm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c1519a15566c94ed3d413a73a0cea1
Autor:
Pruss, M, Dwucet, A, Westhoff, MA, Hlavac, M, Siegelin, MD, Wirtz, CR, Halatsch, ME, Karpel-Massler, G
Publikováno v:
70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie; 20190512-20190515; Würzburg; DOCP054 /20190508/
Objective: The purpose of this study was to examine whether dual reprogramming of the metabolome of glioblastoma cells by imipridone-mediated OXPHOS inhibition and 2-deoxyglucose-mediated inhibition of glycolysis leads to enhanced anti-cancer activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91f5d7bb427a92673e611ea034331f5
Autor:
Halatsch, ME, Kast, RE, Karpel-Massler, G, Schmitz, B, Zolk, O, Bullinger, L, Mayer-Steinacker, R, Maier, L, Scheuerle, A, Mayer, B, Schmidt, C, Zeiler, K, Elshaer, Z, Awad, F, Panther, P, Schmelzle, B, Beckers, K, Siegelin, MD, Westhoff, MA, Wirtz, CR, Bouche, G, Heiland, T
Publikováno v:
70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie; 20190512-20190515; Würzburg; DOCP082 /20190508/
Objective: Despite refinements of neurosurgical techniques and emerging adjuvant therapies, patients with recurrent glioblastoma continue to face a dismal prognosis. We report interim results of a prospective clinical trial (NCT02770378) evaluating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc1bde8883f80fbfa52a1b314dd663d
Autor:
Karpel-Massler, G, Kast, RE, Westhoff, MA, Dwucet, A, Welscher, N, Nonnenmacher, L, Hlavac, M, Siegelin, MD, Wirtz, CR, Debatin, KM, Halatsch, ME
Publikováno v:
66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20150607-20150610; Karlsruhe; DOCMI.09.06 /20150602/
Objective: The continuously poor prognosis of patients with glioblastoma urges the discovery of more effective therapeutics. Repurposing of already existing drugs involves the clinical application of old agents with previously not known or not utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0177359307045af53de3bbc832a111b2
Publikováno v:
64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20130526-20130529; Düsseldorf; DOCMI.13.05 /20130521/
Objective: We have previously reported that combined inhibition of the epidermal growth factor receptor by erlotinib and of RAC1 by NSC23766 yielded a synergistic antiproliferative effect on established and primary glioblastoma cells. The current stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d998cc107155c33ee0506b5a63927d68
Publikováno v:
60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien; 20090524-20090527; Münster; DOCMI.05-06 /20090520/
Objective: Glioblastoma multiforme (GBM) are the most common primary brain tumors and among the deadliest cancers per se. The failure of conventional therapeutic approaches is – at least in part – believed to be due to aberrant activity of the PI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd5a7cbec34f3834f26ac7912aac106