Ibrutinib induces chromatin reorganisation of chronic lymphocytic leukaemia cells

Autor: Holmes, KB, Sadreev, II, Rawstron, AC, Munir, T, Westhead, DR, Hillmen, P, Lefevre, PF

Publikováno v: Oncogenesis, Vol 8, Iss 5, Pp 1-11 (2019)

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in Western countries. It has recently been shown that the homogeneity of the chromatin landscape between CLL cells contrasts with the important observed genetic heterogeneity of the dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a0d345011a35715ef620dd38baa5663d
http://link.springer.com/article/10.1038/s41389-019-0142-2

Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B): an open-label, randomised, phase 3 trial

Autor: Davies, A, Cummin, TE, Barrans, S, Maishman, T, Mamot, C, Novak, U, Caddy, J, Stanton, L, Kazmi-Stokes, S, McMillan, A, Fields, P, Pocock, C, Collins, GP, Stephens, R, Cucco, F, Clipson, A, Sha, C, Tooze, R, Care, MA, Griffiths, G, Du, M-Q, Westhead, DR, Burton, C, Johnson, PWM

Publikováno v: Davies, Andrew; Cummin, Thomas E; Barrans, Sharon; Maishman, Tom; Mamot, Christoph; Novak, Urban; Caddy, Josh; Stanton, Louise; Kazmi-Stokes, Shamim; McMillan, Andrew; Fields, Paul; Pocock, Christopher; Collins, Graham P; Stephens, Richard; Cucco, Francesco; Clipson, Alexandra; Sha, Chulin; Tooze, Reuben; Care, Matthew A; Griffiths, Gareth; ... (2019). Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B): an open-label, randomised, phase 3 trial. The lancet oncology, 20(5), pp. 649-662. Elsevier 10.1016/S1470-2045(18)30935-5

BACKGROUND: Biologically distinct subtypes of diffuse large B-cell lymphoma can be identified using gene-expression analysis to determine their cell of origin, corresponding to germinal centre or activated B cell. We aimed to investigate whether addi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ca200ca0986b184f9bd9d47ac4e133

Molecular high-grade B cell lymphoma: defining a poor risk group requiring different approaches to therapy

Autor: Sha, C, Barrans, S, Cucco, F, Bentley, MA, Care, MA, Cummin, T, Kennedy, H, Thompson, JS, Uddin, R, Worrillow, L, Chalkley, R, van Hoppe, M, Ahmed, S, Maishman, T, Caddy, J, Schuh, A, Mamot, C, Burton, C, Tooze, R, Davies, A, Du, MQ, Johnson, PWM, Westhead, DR

Purpose: Biologic heterogeneity is a feature of diffuse large B-cell lymphoma (DLBCL), and the existence of a subgroup with poor prognosis and phenotypic proximity to Burkitt lymphoma is well known. Conventional cytogenetics identifies some patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9f124f785fb6f5f4abacacd2791c7a90
https://eprints.whiterose.ac.uk/138128/17/jco.18.01314.pdf

Network analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity

Autor: Care, MA, Stephenson, SJ, Barnes, NA, Fan, I, Zougman, A, El-Sherbiny, YM, Vital, EM, Westhead, DR, Tooze, RM, Doody, GM

Publikováno v: Care, M A, Stephenson, S J, Barnes, N A, Fan, I, Zougman, A, El-Sherbiny, Y M, Vital, E M, Westhead, D R, Tooze, R M & Doody, G M 2016, ' Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity ', Journal of immunology (Baltimore, Md. : 1950), vol. 197, no. 4, pp. 1447-59 . https://doi.org/10.4049/jimmunol.1600624

Plasma cells (PCs) as effectors of humoral immunity produce Igs to match pathogenic insult. Emerging data suggest more diverse roles exist for PCs as regulators of immune and inflammatory responses via secretion of factors other than Igs. The extent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::794912401d9c8cef1c3d4bd97cec5b72

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