Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice.

Autor: Down, J D, Westerhof, G R, Boudewijn, A, Setroikromo, R, Ploemacher, R E

Publikováno v: Bone Marrow Transplantation. 2/15/98, Vol. 21 Issue 4, p327. 4p.

The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships

Autor: Jansen, G, Westerhof, G R, Schornagel, J H, Jackman, A L, Boyle, F T

Publikováno v: Advances in Experimental Medicine and Biology, 338, 767-70. Springer New York

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::8551b2a34e6cbdc970bac90c27a452c0
https://research.vumc.nl/en/publications/cc112c97-45dd-4b0e-8f48-a6d1bd06e66a

In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate

Autor: van der Laan, B F, Jansen, G, Kathmann, G A, Westerhof, G R, Schornagel, J H, Hordijk, G J

Publikováno v: van der Laan, B F, Jansen, G, Kathmann, G A, Westerhof, G R, Schornagel, J H & Hordijk, G J 1992, ' In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate ', International Journal of Cancer, vol. 51, no. 6, pp. 909-14 .
International Journal of Cancer, 51(6), 909-14. Wiley-Liss Inc.

A series of 7 human squamous carcinoma cell lines of the head and neck (HNSCC), grown in standard medium containing high folate concentrations and in "folate-conditioned" medium containing nanomolar concentrations of folates, were all found to be sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bde7d4534a7a4ae4aef5c41b76b506a0
https://research.vumc.nl/en/publications/4fdeb9fc-d409-46e3-913d-282e950750c3

Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells:role of carrier- and receptor-mediated transport systems

Autor: Westerhof, G R, Jansen, G, van Emmerik, N, Kathmann, I, Rijksen, G, Jackman, A L, Schornagel, J H

Publikováno v: Westerhof, G R, Jansen, G, van Emmerik, N, Kathmann, I, Rijksen, G, Jackman, A L & Schornagel, J H 1991, ' Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells : role of carrier-and receptor-mediated transport systems ', Cancer Research, vol. 51, no. 20, pp. 5507-13 .

L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10172::2a9e48cfbc7757a69071de1e04d17e4a
https://research.vumc.nl/en/publications/8c46e350-d8d8-415f-95c4-64aa9e3006c4

Synthesis and biological evaluation of a fluorescent analogue of folic acid

Autor: McAlinden, T P, Hynes, J B, Patil, S A, Westerhof, G R, Jansen, G, Schornagel, J H, Kerwar, S S, Freisheim, J H

Publikováno v: Biochemistry, 30(23), 5674-81. American Chemical Society
McAlinden, T P, Hynes, J B, Patil, S A, Westerhof, G R, Jansen, G, Schornagel, J H, Kerwar, S S & Freisheim, J H 1991, ' Synthesis and biological evaluation of a fluorescent analogue of folic acid ', Biochemistry, vol. 30, no. 23, pp. 5674-81 .

A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4'-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a probe for dihydrofolate reductase (DHFR) and a membrane folate binding protein (m-FBP). Excita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::241961afd878fd41609bce80aede7bf9
https://research.vumc.nl/en/publications/ee342f61-7944-45c1-a262-c987d9d35f0e