A structural analysis of the splice-specific functional impact of the pathogenic familial hemiplegic migraine type 1 S218L mutation on Ca v 2.1 P/Q-type channel gating.

Autor: Sack AS; Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Samera GJ; Applied Genomics Centre, Kwantlen Polytechnic University, 12666 - 72 Ave, Surrey, BC, V3W 2M8, Canada., Hissen A; Applied Genomics Centre, Kwantlen Polytechnic University, 12666 - 72 Ave, Surrey, BC, V3W 2M8, Canada., Wester RJ; Applied Genomics Centre, Kwantlen Polytechnic University, 12666 - 72 Ave, Surrey, BC, V3W 2M8, Canada., Garcia E; Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada., Adams PJ; Applied Genomics Centre, Kwantlen Polytechnic University, 12666 - 72 Ave, Surrey, BC, V3W 2M8, Canada., Snutch TP; Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada. snutch@msl.ubc.ca.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. snutch@msl.ubc.ca.

Publikováno v: Molecular brain [Mol Brain] 2024 Nov 20; Vol. 17 (1), pp. 82. Date of Electronic Publication: 2024 Nov 20.