Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.

Autor: Westbrook RL; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Bridges E; Hypoxia and Angiogenesis Group, Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK., Roberts J; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Escribano-Gonzalez C; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Eales KL; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Vettore LA; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Walker PD; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Vera-Siguenza E; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Rana H; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Cuozzo F; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Eskla KL; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia; Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Tartu, Estonia., Vellama H; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia; Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Tartu, Estonia., Shaaban A; University Hospital Birmingham NHS Foundation Trust and Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Nixon C; Beatson Institute for Cancer Research, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK., Luuk H; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia; Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Tartu, Estonia., Lavery GG; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Hodson DJ; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK., Harris AL; Hypoxia and Angiogenesis Group, Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK., Tennant DA; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: d.tennant@bham.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2022 Feb 01; Vol. 38 (5), pp. 110320.

Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice.

Autor: Nasteska D; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, United Kingdom., Cuozzo F; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, United Kingdom., Viloria K; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, United Kingdom., Johnson EM; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom., Thakker A; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Bany Bakar R; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Westbrook RL; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Barlow JP; Mitochondrial Profiling Centre, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom., Hoang M; School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada., Joseph JW; School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada., Lavery GG; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Akerman I; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Cantley J; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.; Division of Systems Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom., Hodson L; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom., Tennant DA; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Hodson DJ; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, United Kingdom.

Publikováno v: JCI insight [JCI Insight] 2021 Aug 23; Vol. 6 (16). Date of Electronic Publication: 2021 Aug 23.