Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.

Autor: Umemura Y; Department of Neurology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Orringer D; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Junck L; Department of Neurology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Varela ML; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; The Rogel Cancer Center, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., West MEJ; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; The Rogel Cancer Center, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Faisal SM; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; The Rogel Cancer Center, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Comba A; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; The Rogel Cancer Center, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Heth J; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Sagher O; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Leung D; Department of Neurology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Mammoser A; Department of Neurology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Hervey-Jumper S; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Zamler D; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Yadav VN; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Dunn P; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Al-Holou W; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Hollon T; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Kim MM; Department of Radiation Oncology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Wahl DR; Department of Radiation Oncology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Camelo-Piragua S; Department of Pathology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Lieberman AP; Department of Pathology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Venneti S; Department of Pathology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., McKeever P; Department of Pathology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Lawrence T; Department of Radiation Oncology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Kurokawa R; Department of Radiology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Sagher K; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Altshuler D; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Zhao L; Department of Biostatistics, The University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA., Muraszko K; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Castro MG; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; The Rogel Cancer Center, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA., Lowenstein PR; Department of Neurosurgery, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; The Rogel Cancer Center, The University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan School of Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: pedrol@umich.edu.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2023 Sep; Vol. 24 (9), pp. 1042-1052.