Výsledky vyhledávání - "Wesley R. Evans"

Autor: Siva SVP Sakamuri, Venkata N Sure, Lahari Kolli, Wesley R Evans, Jared A Sperling, Gregory J Bix, Xiaoying Wang, Dmitriy N Atochin, Walter L Murfee, Ricardo Mostany, Prasad VG Katakam

Publikováno v: J Cereb Blood Flow Metab

Mitochondrial and glycolytic energy pathways regulate the vascular functions. Aging impairs the cerebrovascular function and increases the risk of stroke and cognitive dysfunction. The goal of our study is to characterize the impact of aging on brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a3cd3c4663c1f8344099494ee62391
https://doi.org/10.1177/0271678x211069266

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Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells

Autor: Siva S. V. P. Sakamuri, Venkata N. Sure, Lahari Kolli, Ning Liu, Wesley R. Evans, Jared A. Sperling, David W. Busija, Xiaoying Wang, Sarah H. Lindsey, Walter L. Murfee, Ricardo Mostany, Prasad V. G. Katakam

Publikováno v: GeroScience

Alterations of mitochondrial and glycolytic energy pathways related to aging could contribute to cerebrovascular dysfunction. We studied the impact of aging on energetics of primary human brain microvascular endothelial cells (HBMECs) by comparing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446ede1af773c39096646ac6b5a3609d
https://europepmc.org/articles/PMC9616994/

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Chronic imaging of mitochondria in the murine cerebral vasculature using in vivo two-photon microscopy

Autor: Sinisa Cikic, Wesley R. Evans, Tomas Salter‐Cid, Partha K. Chandra, David W. Busija, Ibolya Rutkai, Ricardo Mostany, Nikita Bess, Prasad V. G. Katakam

Publikováno v: Am J Physiol Heart Circ Physiol

Mitochondria are important regulators of cerebral vascular function in health and disease, but progress in understanding their roles has been hindered by methodological limitations. We report the first in vivo imaging of mitochondria specific to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b47135858e5963adca54f8d39d1792
https://doi.org/10.1152/ajpheart.00751.2019

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Nitric oxide synthase inhibitors negatively regulate respiration in isolated rodent cardiac and brain mitochondria

Autor: Jared A. Sperling, Wesley R. Evans, Siva S.V.P. Sakamuri, Aaron L. Albuck, Ricardo Mostany, Prasad V. G. Katakam, Monica H. Dholakia, Ryousuke Satou, Venkata N. Sure

Publikováno v: Am J Physiol Heart Circ Physiol

Nitric oxide (NO) is known to exert inhibitory control on mitochondrial respiration in the heart and brain. Evidence supports the presence of NO synthase (NOS) in the mitochondria (mtNOS) of cells; however, the functional role of mtNOS in the regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8ac313f9807694bacae8c00ed4bcef
https://doi.org/10.1152/ajpheart.00720.2019

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Abstract TP248: Nos Inhibitor Is An Effective Adjuvant To Reperfusion Therapy In Ischemic Stroke In Mice

Autor: William P Wisen, Wesley R Evans, Venkata N Sure, Siva S Sakamuri, Lahari Kolli, Aaron L Albuck, Ricardo Mostany, Prasad V Katakam

Publikováno v: Stroke. 53

Background: Inhibition nitric oxide synthase (NOS) has been shown to paradoxically protect against ischemic brain injury by an unknown mechanism. Recently, we found that NOS inhibitor, N (gamma)-nitro-L-arginine methyl ester (L-NAME), protects primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acecbf42a424ab6eaa98e6eb7157723a
https://doi.org/10.1161/str.53.suppl_1.tp248

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Abstract WP245: Sex-dependent Regulation Of Mitochondrial Respiratory Function In Mouse Brain Microvessels By Peroxynitrite Decomposition Catalyst

Autor: Siva S Sakamuri, Lahari Kolli, William P Wisen, Venkata N Sure, Wesley R Evans, Sarah H Lindsey, Ricardo Mostany, Prasad V Katakam

Publikováno v: Stroke. 53

Background: Peroxynitrite (PN) is a strong oxidizing and nitrating molecule. PN is a potent inhibitor of mitochondrial respiration and mediates the ischemia-reperfusion injury following stroke. In isolated mouse brain mitochondria, we observed that P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97ffc47f84d8db1e3108a582bceaf6ed
https://doi.org/10.1161/str.53.suppl_1.wp245

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Peroxynitrite decomposition catalyst enhances respiratory function in isolated brain mitochondria

Autor: Jared A. Sperling, Ricardo Mostany, Wesley R. Evans, Aaron L. Albuck, Venkata N. Sure, Lahari Kolli, Prasad V. G. Katakam, Siva S.V.P. Sakamuri

Publikováno v: Am J Physiol Heart Circ Physiol

Peroxynitrite (PN), generated from the reaction of nitric oxide (NO) and superoxide, is implicated in the pathogenesis of ischemic and neurodegenerative brain injuries. Mitochondria produce NO from mitochondrial NO synthases and superoxide by the ele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26df3dac4e4b1851d07035589bd16056
https://pubmed.ncbi.nlm.nih.gov/33164581

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