Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Wesley P. Wong"'
Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The conversion of auditory and vestibular stimuli into electrical signals is initiated by force transmitted to a mechanotransduction channel through the tip link. Here authors show that a single tip-link bond is more mechanically stable relative to c
Externí odkaz:
https://doaj.org/article/cedc8ced7e7c4b7984736d122c8d046c
Autor:
Yu-San Huoh, Bin Wu, Sehoon Park, Darren Yang, Kushagra Bansal, Emily Greenwald, Wesley P. Wong, Diane Mathis, Sun Hur
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the
Externí odkaz:
https://doaj.org/article/eb5aeaaa407a4884ae20cf4e411315b1
Autor:
Hongxia Fu, Yan Jiang, Darren Yang, Friedrich Scheiflinger, Wesley P. Wong, Timothy A. Springer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Von Willebrand factor (VWF) is a blood protein involved in clotting and is proposed to be activated by flow, but the mechanism is unknown. Here the authors show that VWF is first converted from a compact to linear form by flow, and is subsequently ac
Externí odkaz:
https://doaj.org/article/a5fbfb5781ac4911a873b2e2e5610c15
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Single molecule force spectroscopy (SMFS) has limitations in throughput and the ability to repeatedly interrogate single bonds. Here the authors repurpose a benchtop centrifuge and use DNA nanoswitches to enable high throughput SMFS capable of repeat
Externí odkaz:
https://doaj.org/article/461600ab61c74653a81a639f445b8670
Autor:
Molly S.C. Li, M.B.B.S., Kirsty W.C. Lee, MBChB, Kevin K.S. Mok, MBChB, Herbert H.F. Loong, M.B.B.S., K.C. Lam, MBChB, Florence S.T. Mok, M.B.B.S., Landon L. Chan, MBChB, Y.M. Lau, M.B.B.S., K.P. Chan, MBChB, Joyce T.Y. Ng, MBChB, Wesley K.Y. Wong, M.B.B.S., Benjamin H.W. Lam, M.B.B.S., Allen C.C. Chen, BM, Matthew M.P. Lee, MBChB, Olivia H. Chen, MD, PhD, Tony S.K. Mok, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 4, Pp 100648- (2024)
Introduction: Interstitial lung disease (ILD) is the most frequent cause of drug-related mortality from EGFR tyrosine kinase inhibitors (TKIs). Yet, for patients with symptomatic osimertinib-induced ILD, the risk of recurrent ILD associated with EGFR
Externí odkaz:
https://doaj.org/article/3e7352949ccd4e5d8d2933a594642014
Autor:
Yi Luo, Jeffrey Chang, Darren Yang, J. Shepard Bryan, Molly MacIsaac, Steve Pressé, Wesley P. Wong
Publikováno v:
Journal of the American Chemical Society. 145:3276-3282
Autor:
Andrew Ward, Darren Yang, Wesley P. Wong, Serkan Cabi, Elisha Krieg, Bhavik Nathwani, Prakash Shrestha, Yi Luo, Toma E. Tomov, William M. Shih, James I. MacDonald, Hans T. Bergal, Alexander Johnson-Buck
Publikováno v:
Nature Nanotechnology. 16:1362-1370
Decoding the identity of biomolecules from trace samples is a longstanding goal in the field of biotechnology. Advances in DNA analysis have substantially affected clinical practice and basic research, but corresponding developments for proteins face
Publikováno v:
Blood. 138(23)
von Willebrand factor (VWF) is an ultralong concatemeric protein important in hemostasis and thrombosis. VWF molecules can associate with other VWF molecules, but little is known about the mechanism. Hydrodynamic drag exerts tensile force on surface-
Publikováno v:
Journal of Molecular Biology. 431:1380-1396
Von Willebrand factor (VWF), a large multimeric blood protein, senses changes in shear stress during bleeding and responds by binding platelets to plug ruptures in the vessel wall. Molecular mechanisms underlying this dynamic process are difficult to
Autor:
Daniel E. Neafsey, Angela M. Early, Daniel L. Hartl, Selina Bopp, Dyann F. Wirth, Seth Redmond, Wesley P. Wong, Aabha I. Sharma, Sarah K. Volkman, Allison Demas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The spread of Plasmodium falciparum with reduced susceptibility to artemisinin (ART) in Southeast Asia threatens global malaria control. Most failures of ART treatment are attributed to mutations in the pfkelch13 locus acting through an