Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Wesley M. Botello-Smith"'
Autor:
Wesley M. Botello-Smith, Wenjuan Jiang, Han Zhang, Alper D. Ozkan, Yi-Chun Lin, Christine N. Pham, Jérôme J. Lacroix, Yun Luo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Besides mechanical forces, the mechanosensitive channel Piezo1 is activated by the small molecule Yoda1 through an unknown mechanism. Here, using molecular dynamics simulations, calcium imaging and electrophysiology, the authors identify an allosteri
Externí odkaz:
https://doaj.org/article/8c1aeda44ea9466cae5d0b05d2bf2fe1
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Piezo ion channels transduce mechanical stimuli into biological signals but the underlying mechanism has remained elusive. Here, the authors use the selective agonist Yoda1 to identify molecular determinants of Piezo activation, providing mechanistic
Externí odkaz:
https://doaj.org/article/3a4609bc5a3f476f90902b6c75f467b5
Autor:
Shane D Anderson, Asna Tabassum, Jae Kyung Yeon, Garima Sharma, Priscilla Santos, Tik Hang Soong, Yin Win Thu, Isaac Nies, Tomomi Kurita, Andrew Chandler, Abdelaziz Alsamarah, Rhye-Samuel Kanassatega, Yun L Luo, Wesley M Botello-Smith, Bradley T Andresen
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1007719 (2020)
Angiotensin II type 1 receptor (AT1R) blockers (ARBs) are among the most prescribed drugs. However, ARB effectiveness varies widely, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT1R gene. The AT1R coding seq
Externí odkaz:
https://doaj.org/article/9057f3767c6a46328700c2fefa4f9edc
Autor:
Yun Lyna Luo, Wenjuan Jiang, Yi-Chun Lin, Wesley M. Botello-Smith, Andrew L. Harris, Jorge E Contreras, Luca Maragliano
Publikováno v:
Biophysical journal, vol 120, iss 15
Biophys J
Biophys J
The connexin family is a diverse group of highly regulated wide-pore channels permeable to biological signaling molecules. Despite the critical roles of connexins in mediating selective molecular signaling in health and disease, the basis of molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452cf7a31439e869be6476ded083fece
https://escholarship.org/uc/item/05p001xv
https://escholarship.org/uc/item/05p001xv
Publikováno v:
Biophysical Journal. 121:187a-188a
Autor:
Yun Luo, Wesley M. Botello-Smith
Publikováno v:
Journal of Chemical Theory and Computation. 15:2116-2126
To understand how protein function changes upon an allosteric perturbation, such as ligand binding and mutation, significant progress in characterizing allosteric network from molecular dynamics (MD) simulations has been made. However, determining wh
Autor:
Alejandro Peinado, Mona M. Freidin, Yun Luo, Rola Mahmoud, Charles K. Abrams, Matan Bocarsly, Paul Chang, Han Zhang, Wesley M. Botello-Smith
Publikováno v:
American Journal of Physiology-Cell Physiology. 315:C623-C635
The connexins are members of a family of integral membrane proteins that form gap junction channels between apposed cells and/or hemichannels across the plasma membranes. The importance of the arginine at position 76 (Arg76) in the structure and/or f
Autor:
Wesley M, Botello-Smith, Yun Lyna, Luo
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2302
Over the past decade, concepts of network theory in combination with dynamical information from conformational ensembles have been widely applied to gain insights in understanding allosteric regulation in biomolecules. In this chapter, we introduce t
Autor:
Yi-Chun Lin, Yun Luo, Wenjuan Jiang, Andrew L. Harris, Wesley M. Botello-Smith, Luca Maragliano, Jorge E. Contreras
The connexin family is a diverse group of highly regulated non-β-barrel wide-pore channels permeable to biological signaling molecules. Despite their critical roles in mediating selective molecular signaling in health and disease, the molecular basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6340a6d575281058834ab340ae109bf
https://doi.org/10.1101/2021.01.18.427208
https://doi.org/10.1101/2021.01.18.427208
Autor:
Yun Lyna Luo, John Smith Del Rosario, Yi-Chun Lin, Wenjuan Jiang, Jerome J. Lacroix, Wesley M. Botello-Smith, Siyuan Zhao, Tibor Rohacs, Han Zhang
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mechanosensitive Piezo1 channels are essential mechanotransduction proteins in eukaryotes. Their curved transmembrane domains, called arms, create a convex membrane deformation, or footprint, which is predicted to flatten in response to increased mem