High-throughput Interpretation of Killer-cell Immunoglobulin-like Receptor Short-read Sequencing Data with PING.

Autor: Wesley M Marin, Ravi Dandekar, Danillo G Augusto, Tasneem Yusufali, Bianca Heyn, Jan Hofmann, Vinzenz Lange, Jürgen Sauter, Paul J Norman, Jill A Hollenbach

Publikováno v: PLoS Computational Biology, Vol 17, Iss 8, p e1008904 (2021)

The killer-cell immunoglobulin-like receptor (KIR) complex on chromosome 19 encodes receptors that modulate the activity of natural killer cells, and variation in these genes has been linked to infectious and autoimmune disease, as well as having bea

Externí odkaz: https://doaj.org/article/4880db1e9f7e492dafc5a56310cfa057

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors

Autor: Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Wesley M. Marin, Sudan Tao, Lorenzo Moretta, Jill A. Hollenbach, John Trowsdale, James A. Traherne, Abbas Ghaderi, Peter Parham, Paul J. Norman

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands. Directly impacting NK cell f

Externí odkaz: https://doaj.org/article/8759d92b23c14ad39042c5176a30a02a

Software Update: Interpreting Killer-cell Immunoglobulin-like Receptors from Whole Genome Sequence Data with PING

Autor: Wesley M. Marin, Jill A. Hollenbach

Publikováno v: HLA.

Here, we demonstrate improvements to our bioinformatic pipeline, PING, which provides high-resolution genotyping of killer-cell immunoglobulin-like receptor (KIR) sequencing data, that expand the method to provide KIR interpretation from whole genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce164525c2ad9388a7b87c8361ee523
https://pubmed.ncbi.nlm.nih.gov/36565030

Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease

Autor: Peter Parham, Mohammad R. K. Mofrad, Paul Norman, Neda Nemat-Gorgani, Wesley M. Marin, Tasneem Yusufali, Ravi Dandekar, Jill A. Hollenbach, Stacy J. Caillier, Marcelo Fernandez-Vina, Danillo G. Augusto, Kirsten M. Anderson, Hengameh Shams, Lisa E. Creary, Chao Zhao, Jorge R. Oksenberg, Gonzalo Montero-Martín

Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 205, iss 5
J Immunol

Immune dysfunction plays a role in the development of Parkinson disease (PD). NK cells regulate immune functions and are modulated by killer cell immunoglobulin-like receptors (KIR). KIR are expressed on the surface of NK cells and interact with HLA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41511bff8e1b12eb49de59e23be99fc3
https://doi.org/10.4049/jimmunol.2000144

A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson’s disease

Autor: Marcelo Fernandez-Vina, Stephen L. Hauser, Maneesh K. Misra, Wesley M. Marin, Jorge R. Oksenberg, Jill A. Hollenbach, Neda Nemat-Gorgani, Adam Renschen, Adam Santaniello, Lisa E. Creary, Kirsten M. Anderson, Gonzalo Montero-Martín, Vincent Damotte, Caroline M. Tanner, Kazutoyo Osoegawa, Paul Norman, Peter Parham, Ravi Dandekar, Stacy J. Caillier

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 15

Significance Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease with both familial and sporadic forms and a clear genetic component. In addition, underlying immunoregulatory dysfunction and inflammatory processes have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c292928d2d116e0c807d5e35c253e992
http://europepmc.org/articles/PMC6462083