Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wesley Lebel"'
Autor:
Frank E. Ewing, Jon Bordner, Wesley Lebel, Heidi A. Woody, R. Michael Snider, Kelly P. Longo, Jay W. Constantine, John A. Lowe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:839-842
The synthesis and SAR of a series of 2-aryl-1-azabicyclo[2.2.2]octanes structurally related to the nonpeptide substance P antagonists CP-96,345 and CP-99,994 are described. The novel SAR observed at the 2-position in these derivatives represents a hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9127aa76d8f80b8e1ac787e2a9a59dfa
https://doi.org/10.1016/s0960-894x(01)80859-3
https://doi.org/10.1016/s0960-894x(01)80859-3
Autor:
Wesley Lebel, Delvin R. Knight, Eric A. Wolfgang, Jay W. Constantine, Heidi A. Woody, Patricia A. Benoit
Publikováno v:
European Journal of Pharmacology. 252:275-282
CP-96,345, a non-peptide, selective tachykinin NK1 receptor blocker and its inactive enantiomer, CP-96,344, inhibit ligand binding of phenylalkylamine but not dihydropyridine Ca2+ channel antagonists. Whether these Ca2+ channel antagonist properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90afc7c84df03a9d0fed5a21cb7e28ab
https://doi.org/10.1016/0014-2999(94)90173-2
https://doi.org/10.1016/0014-2999(94)90173-2
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 342:722-724
Neurokinin A, neurokinin B and substance P caused concentration-related contractions of rabbit isolated aorta with pD2 values of 8.1, 6.9, and 6.0, respectively. [D-Pro2, D-Trp7, 9]-substance P, a competitive tachykinin antagonist, had pA2 values of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d2fc25934577a65a995ac77eed8376
https://doi.org/10.1007/bf00175719
https://doi.org/10.1007/bf00175719
Autor:
K. G. Pratt, R. M. Snider, K. P. Longo, J. A. Lowe, S. McLean, Heidi A. Woody, Dianne K. Bryce, Jon Bordner, Wesley Lebel, S. E. Drozda, T. F. Seeger, J. W. Constantine
Publikováno v:
Peptides ISBN: 9789401050050
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2973b61cebd6f32de38bc755904179aa
https://doi.org/10.1007/978-94-011-2264-1_311
https://doi.org/10.1007/978-94-011-2264-1_311
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 344
The effects of substance P, neurokinin A, neurokinin B, [Sar9, Met(O2)11]-substance P, [Nle10]-neurokinin A (4-10) and senktide (succinyl-[Asp6, MePhe8]-substance P (6-11)) on blood pressure and heart rate were studied in anesthetized dogs. Dose-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b06f162786630ce7999c08f6b489e3
https://doi.org/10.1007/bf00172588
https://doi.org/10.1007/bf00172588
Publikováno v:
European Journal of Pharmacology. 85:325-329
Phenoxybenzamine greatly attenuated phenylephrine-induced contractions of dog saphenous vein in vitro, but had less effect on contractions induced by clonidine. The phenozybenzamine-resistant responses to clonidine were not affected by prazosin or by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7e096a3cf298b97d26d7ed45e67aa8
https://doi.org/10.1016/0014-2999(82)90219-9
https://doi.org/10.1016/0014-2999(82)90219-9
Publikováno v:
American Heart Journal. 106:1216-1221
As part of an ongoing investigation into the cardiovascular properties of trimazosin, 99 male Sprague-Dawley rats were anesthetized and cannulas were placed in jugular veins for administration of drugs. The rats were injected with phenylephrine and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aec8166cbbfa0130461423a47bb21cb
https://doi.org/10.1016/0002-8703(83)90178-3
https://doi.org/10.1016/0002-8703(83)90178-3
Publikováno v:
European journal of pharmacology. 79(1-2)
Intravertebral artery injection of yohimbine at total doses of 10, 50, 100 and 200 micrograms caused dose-related enhancement of the systemic pressor response to bilateral carotid artery occlusion (BCO) in dogs; the response was depressed by 5000 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5faf8e22e75c10d1482cc38d8321dc0
https://pubmed.ncbi.nlm.nih.gov/6123436
https://pubmed.ncbi.nlm.nih.gov/6123436
Autor:
Wesley Lebel, Jay W. Constantine
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 314(2)
In pithed dogs pressor responses to phenylephrine were completely inhibited 1 h after phenoxybenzamine 20 mg/kg i.v., but those to norepinephrine were only partially inhibited. The pressor effects of norepinephrine in phenoxybenzamine-treated animals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2272c99f7cd7f474da16ef54b431b977
https://pubmed.ncbi.nlm.nih.gov/6256667
https://pubmed.ncbi.nlm.nih.gov/6256667
Autor:
Constantine, Jay, Lebel, Wesley
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology; 1980, Vol. 314 Issue 2, p149-156, 8p