Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Wesley L Cai"'
Autor:
Jin Wei, Mia Madel Alfajaro, Wesley L Cai, Vincent R Graziano, Madison S Strine, Renata B Filler, Scott B Biering, Sylvia A Sarnik, Sonam Patel, Bridget L Menasche, Susan R Compton, Silvana Konermann, Patrick D Hsu, Robert C Orchard, Qin Yan, Craig B Wilen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011351 (2023)
Identification of host determinants of coronavirus infection informs mechanisms of pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes infection of diverse coronaviruses, including
Externí odkaz:
https://doaj.org/article/96107a75fb7e477fb76c01fbddef0ecf
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.
Autor:
Madison S Strine, Wesley L Cai, Jin Wei, Mia Madel Alfajaro, Renata B Filler, Scott B Biering, Sylvia Sarnik, Ryan D Chow, Ajinkya Patil, Kasey S Cervantes, Clayton K Collings, Peter C DeWeirdt, Ruth E Hanna, Kevin Schofield, Christopher Hulme, Silvana Konermann, John G Doench, Patrick D Hsu, Cigall Kadoch, Qin Yan, Craig B Wilen
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002097 (2023)
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding of Coronavirus Disease 2019 (COVID-19). We previously performed a genome-wi
Externí odkaz:
https://doaj.org/article/c10dd58b10dd439eb9610eccf28fbb91
Autor:
Wesley L Cai, Jocelyn Fang-Yi Chen, Huacui Chen, Emily Wingrove, Sarah J Kurley, Lok Hei Chan, Meiling Zhang, Anna Arnal-Estape, Minghui Zhao, Amer Balabaki, Wenxue Li, Xufen Yu, Ethan D Krop, Yali Dou, Yansheng Liu, Jian Jin, Thomas F Westbrook, Don X Nguyen, Qin Yan
Publikováno v:
eLife, Vol 11 (2022)
Metastatic breast cancer remains a major cause of cancer-related deaths in women, and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor progression and metastasis are controlled by rev
Externí odkaz:
https://doaj.org/article/58606a0ba92e4cb2b78d6211456a60e4
Autor:
Lili Liao, Zongzhi Z Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Yuxin Wang, George R Stark, Jianxin Sun, Stephen C Peiper, Yaomin Xu, Qin Yan, Haifeng Yang
Publikováno v:
eLife, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/a50046e84ed442a683b9fc60b5d5c454
Autor:
Lili Liao, Zongzhi Z Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Yuxin Wang, George R Stark, Jianxin Sun, Stephen Peiper, Yaomin Xu, Qin Yan, Haifeng Yang
Publikováno v:
eLife, Vol 7 (2018)
Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, including PBRM1, KDM5C/JARID1C, SETD2, and/or BAP1, remains
Externí odkaz:
https://doaj.org/article/469424e6a2dc4921b7e109a9d371cd8e
Autor:
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://doaj.org/article/b82bd2d7d5a04000a7a64e580355ce3f
Autor:
Mingzhu Yin, Ying Guo, Rui Hu, Wesley L. Cai, Yao Li, Shiyao Pei, Hongyin Sun, Cong Peng, Jiali Li, Rui Ye, Qiaohong Yang, Nenghui Wang, Yongguang Tao, Xiang Chen, Qin Yan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targ
Externí odkaz:
https://doaj.org/article/59a306de0a994d95ae774f48771aeb95
Autor:
Jin Wei, Ajinkya Patil, Clayton K. Collings, Mia Madel Alfajaro, Yu Liang, Wesley L. Cai, Madison S. Strine, Renata B. Filler, Peter C. DeWeirdt, Ruth E. Hanna, Bridget L. Menasche, Arya Ökten, Mario A. Peña-Hernández, Jon Klein, Andrew McNamara, Romel Rosales, Briana L. McGovern, M. Luis Rodriguez, Adolfo García-Sastre, Kris M. White, Yiren Qin, John G. Doench, Qin Yan, Akiko Iwasaki, Thomas P. Zwaka, Jun Qi, Cigall Kadoch, Craig B. Wilen
Publikováno v:
Nature Genetics. 55:471-483
Identification of host determinants of coronavirus infection informs mechanisms of viral pathogenesis and can provide new drug targets. Here we demonstrate that mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) chromatin remodeling complexes, speci
Autor:
Don X. Nguyen, Malaiyalam Mariappan, Paul D. Cao, Minghui Zhao, Zongzhi Liu, Gary W. Cline, Anna Arnal-Estapé, Wesley L. Cai, Sally J. Adua, Alexandra E. Albert
This figure shows that ASNS mediates protein translation during amino acid deprivation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15356a23ce1ab1d69525e1eb42f4a183
https://doi.org/10.1158/1541-7786.22513200.v1
https://doi.org/10.1158/1541-7786.22513200.v1
Autor:
Don X. Nguyen, Malaiyalam Mariappan, Paul D. Cao, Minghui Zhao, Zongzhi Liu, Gary W. Cline, Anna Arnal-Estapé, Wesley L. Cai, Sally J. Adua, Alexandra E. Albert
Supplementary Table 2 shows differential gene expression in LUAD cells treated with ISRIB during asparagine deprivation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd874e05f1d07c112067fa22289a4fa
https://doi.org/10.1158/1541-7786.22513179
https://doi.org/10.1158/1541-7786.22513179