Výsledky vyhledávání - "Wesley J. Jun"

Abstract P4-16-05: Hsp90 inhibition potentiates chemotherapy effectiveness in triple negative breast cancer: Role of glucocorticoid receptor signaling

Autor: Maxwell N. Skor, D Proia, Suzanne D. Conzen, Wesley J. Jun, N Lee, Abena S. Agyeman

Publikováno v: Cancer Research. 73:P4-16

Background: Few promising molecular targets exist for chemoresistant triple negative breast cancer (TNBC). Our laboratory has previously demonstrated that a subset of TNBCs express high glucocorticoid receptor (GR) levels. In breast epithelial cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::118b9421fcb628f47229fba288141873
https://doi.org/10.1158/0008-5472.sabcs13-p4-16-05

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Abstract 3100: Hsp90 inhibition results in GR, AR and JAK protein degradation, decreased triple-negative breast cancer proliferation and increased paclitaxel sensitivity

Autor: Abena S. Agyeman, Wesley J. Jun, Suzanne D. Conzen

Publikováno v: Cancer Research. 76:3100-3100

Glucocorticoid receptor (GR) activity in triple-negative breast cancer (TNBC) is associated with cell survival and chemotherapy resistance. Targetable molecular drivers for TNBC have been difficult to identify and therefore standard treatment remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1298ec8af2777d4e728f30b9c21d4226
https://doi.org/10.1158/1538-7445.am2016-3100

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